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ID 53677
JaLCDOI
フルテキストURL
Thumnail 69_5_307.pdf 1.98 MB
著者
Wada, Nozomu Department of Gastroenterology, Okayama University Hospital
Nouso, Kazuhiro Department of Gastroenterology, Okayama University Hospital
Kariyama, Kazuya Liver Disease Center, Okayama Citizenʼs Hospital
Wakuta, Akiko Liver Disease Center, Okayama Citizenʼs Hospital
Kishida, Masayuki Liver Disease Center, Okayama Citizenʼs Hospital
Nishimura, Mamoru Liver Disease Center, Okayama Citizenʼs Hospital
Higashi, Toshihiro Liver Disease Center, Okayama Citizenʼs Hospital
抄録
Sarcoidosis is a systemic disease characterized by the formation of non-caseating granulomas in multiple organs. In the diagnosis of sarcoidosis, imaging modalities such as ultrasonography, computed tomography (CT) and magnetic resonance imaging (MRI) are useful;however, there are few reports of MRI imaging using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB) MRI. A 46-year-old Japanese female with suspected pulmonary sarcoidosis was admitted to our hospital because low-density mottles in the liver were observed incidentally by chest CT. The low-density mottles were not enhanced at the arterial phase or portal phase by abdominal CT and MRI, and decreased uptake was observed in the hepatobiliary phase of Gd-EOB MRI. No hematological disorder was observed except for a slight increase of biliary enzymes. The lesion was diagnosed as liver sarcoidosis by the liver biopsy. Since the patient refused steroid therapy, we prescribed ursodeoxycholic acid (UDCA). 600mg/day. The serum levels of biliary enzymes were normalized and the abdominal CT findings gradually improved after the initiation of UDCA medication. Gd-EOB MRI showed unique hypointense areas in the liver at the hepatobiliary phase, which might be useful in the diagnosis of liver sarcoidosis.
キーワード
liver sarcoidosis
ursodeoxycholic acid (UDCA)
gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB)
Amo Type
Case Report
発行日
2015-10
出版物タイトル
Acta Medica Okayama
69巻
5号
出版者
Okayama University Medical School
開始ページ
307
終了ページ
311
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT