フルテキストURL GGI_16_4_440.pdf fig.pdf
著者 Tokuchi, Ryo| Hishikawa, Nozomi| Matsuzono, Kosuke| Takao, Yoshiki| Wakutani, Yosuke| Sato, Kota| Kono, Syoichiro| Ohta, Yasuyuki| Deguchi, Kentaro| Yamashita, Toru| Abe, Koji|
抄録 AIM: The aim of the present study was to compare the effects of a galantamine only therapy and a combination therapy with galantamine plus ambulatory cognitive rehabilitation for Alzheimer's disease patients. METHODS: For this retrospective cohort study, we enrolled 86 patients with Alzheimer's disease, dividing them into two groups - a galantamine only group (group G, n = 45) and a combination with galantamine plus ambulatory rehabilitation group (group G + R, n = 41). The present cognitive rehabilitation included a set of physical therapy, occupational therapy and speech therapy for 1-2 h once or twice a week. We compared the Mini-Mental State Examination and Frontal Assessment Battery for cognitive assessment, and Geriatric Depression Scale, Apathy Scale, and Abe's Behavioral and Psychological Symptoms of Dementia score for affective assessment in two groups over 6 months. RESULTS: The baseline Mini-Mental State Examination score was 20.2 and 18.7 in groups G and G + R, respectively. Other baseline data (Frontal Assessment Battery, Geriatric Depression Scale, Apathy Scale, and Abe's Behavioral and Psychological Symptoms of Dementia) were not different between the two groups. Although group G kept all the scores stable until 6 months of the treatment, the Apathy Scale score showed a significant improvement in group G + R as early as 3 months, followed by the Mini-Mental State Examination and Frontal Assessment Battery improvements at 6 months (*P = 0.04 and *P = 0.02, respectively). The Geriatric Depression Scale and Abe's Behavioral and Psychological Symptoms of Dementia did not show any changes. CONCLUSION: The combination therapy of galantamine plus ambulatory cognitive rehabilitation showed a superior benefit both on cognitive and affective functions than galantamine only therapy in Alzheimer's disease patients.
キーワード Alzheimer's disease affective function cognitive function combination therapy galantamine
備考 This is an Accepted Manuscript of an article published by Wiley
発行日 2016-04
出版物タイトル Geriatrics & Gerontology International
16巻
4号
出版者 Japan Geriatrics Society
開始ページ 440
終了ページ 445
ISSN 1444-1586
NCID AA1155729X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 25952367
DOI 10.1111/ggi.12488
Web of Sience KeyUT 000373611800005
関連URL isVersionOf https://doi.org/10.1111/ggi.12488