JaLCDOI 10.18926/AMO/31736
フルテキストURL fulltext.pdf
著者 Gomita, Yutaka| Ichimaru, Yasuyuki| Ohizumi, Norihide| Yamada, Hirotoshi| Moriyama, Mimehiro| Araki, Yasunori|
抄録 <p>The anti-ulcer action of clotiazepam (a thienodiazepine derivative) was studied in mice subjected to non-physical and physical stimuli in a communication box. There were two groups of mice: the &#34;sender&#34; mice that received electric shocks on the feet and responded by squealing and jumping, and the &#34;responder&#34; mice that were affected by the senders' responses without receiving shocks on the feet. Gastric ulcers resulted in both groups. The effect of clotiazepam was compared with that of diazepam. The incidence of gastric ulcers was suppressed by clotiazepam at a dose of 3 mg/kg, per os, in &#34;responder&#34; and &#34;sender&#34; mice, and by diazepam at a dose of 1 mg/kg, per os, in &#34;responder&#34; mice. These results suggest that clotiazepam has a suppressive action against gastric ulcers produced by non-physical or physical stimuli, although its potency is slightly weaker than that of diazepam.</p>
キーワード gastric ulcer clotiazepam non-physical and physical stimuli mice
Amo Type Article
発行日 1987-12
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 275
終了ページ 278
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 2894110
Web of Science KeyUT A1987L530300006