このエントリーをはてなブックマークに追加
ID 48706
フルテキストURL
著者
Kataoka, Takahiro Graduate School of Health Sciences, Okayama University
Teraoka, Junichi Graduate School of Health Sciences, Okayama University
Sakoda, Akihiro Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Nishiyama, Yuichi Graduate School of Health Sciences, Okayama University
Yamato, Keiko Graduate School of Health Sciences, Okayama University
Monden, Mayuko Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
Ishimori, Yuu Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Nomura, Takaharu Radiation Safety Research Center, Central Research Institute of Electric Power Industry
Taguchi, Takehito Graduate School of Health Sciences, Okayama University
Yamaoka, Kiyonori Graduate School of Health Sciences, Okayama University
抄録
We assessed whether radon inhalation inhibited carrageenan-induced inflammation in mice. Carrageenan (1% v/v) was injected subcutaneously into paws of mice that had or had not inhaled approximately 2,000 Bq/m3 of radon for 24 h. Radon inhalation significantly increased superoxide dismutase (SOD) and catalase activities and significantly decreased lipid peroxide levels in mouse paws, indicating that radon inhalation activates antioxidative functions. Carrageenan administration induced paw edema and significantly increased tumor necrosis factor-alpha (TNF-α) and nitric oxide in serum. However, radon inhalation significantly reduced carrageenan-induced paw edema. Serum TNF-α levels were lower in the radon-treated mice than in sham-treated mice. In addition, SOD and catalase activities in paws were significantly higher in the radon-treated mice than in the sham-treated mice. These findings indicated that radon inhalation had anti-inflammatory effects and inhibited carrageenan-induced inflammatory paw edema.
キーワード
radon inhalation
inflammation
carrageenan
edema
antioxidative function
発行日
2012-04-01
出版物タイトル
Inflammation
35巻
2号
出版者
Springer Science+Business Media, LLC
開始ページ
713
終了ページ
722
ISSN
0360-3997
NCID
AA00673765
資料タイプ
学術雑誌論文
オフィシャル URL
http://www.springerlink.com/content/l301166n92348401/
言語
English
OAI-PMH Set
岡山大学
著作権者
© Springer Science+Business Media, LLC 2011
論文のバージョン
author
査読
有り
DOI
PubMed ID
Web of Sience KeyUT