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ID 48968
フルテキストURL
著者
Kataoka, Takahiro Graduate School of Health Sciences, Okayama University
Nishiyama, Yuichi Graduate School of Health Sciences, Okayama University
Yamato, Keiko Graduate School of Health Sciences, Okayama University
Teraoka, Junichi Graduate School of Health Sciences, Okayama University
Morii, Yuji Graduate School of Health Sciences, Okayama University
Sakoda, Akihiro Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Ishimori, Yuu Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Taguchi, Takehito Graduate School of Health Sciences, Okayama University
Yamaoka, Kiyonori Graduate School of Health Sciences, Okayama University
抄録
We have previously reported that radon inhalation activates anti-oxidative functions and inhibits carbon tetrachloride (CCl(4))-induced hepatopathy. It has also been reported that antioxidant vitamins can inhibit CCl(4)-induced hepatopathy. In the current study, we examined the comparative efficacy of treatment with radon, ascorbic acid and α-tocopherol on CCl(4)-induced hepatopathy. Mice were subjected to intraperitoneal injection of CCl(4) after inhaling approximately 1000 or 2000 Bq/m(3) radon for 24 h, or immediately after intraperitoneal injection of ascorbic acid (100, 300, or 500 mg/kg bodyweight) or α-tocopherol (100, 300, or 500 mg/kg bodyweight). We estimated the inhibitory effects on CCl(4)-induced hepatopathy based on hepatic function-associated parameters, oxidative damage-associated parameters and histological changes. The results revealed that the therapeutic effects of radon inhalation were almost equivalent to treatment with ascorbic acid at a dose of 500 mg/kg or α-tocopherol at a dose of 300 mg/kg. The activities of superoxide dismutase, catalase, and glutathione peroxidase in the liver were significantly higher in mice exposed to radon than in mice treated with CCl(4) alone. These findings suggest that radon inhalation has an anti-oxidative effect against CCl(4)-induced hepatopathy similar to the anti-oxidative effects of ascorbic acid or α-tocopherol due to the induction of anti-oxidative functions.
キーワード
Radon
ascorbic acid
α-tocopherol
antioxidant
hepatopathy
発行日
2012-07-31
出版物タイトル
Journal of Radiation Research
53巻
6号
出版者
Japan Radiation Research Society and Japanese Society for Therapeutic Radiology and Oncology
開始ページ
830
終了ページ
839
ISSN
0449-3060
NCID
AA00705792
資料タイプ
学術雑誌論文
オフィシャル URL
http://jrr.oxfordjournals.org/content/53/6/830
言語
English
OAI-PMH Set
岡山大学
著作権者
Copyright © 2012 Japan Radiation Research Society and Japanese Society for Therapeutic Radiology and Oncology
論文のバージョン
publisher
査読
有り
DOI
PubMed ID