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ID 31825
JaLCDOI
フルテキストURL
著者
Makita, Ryuji Department of General Medicine, Kyorin University School of Medicine
Kokaze, Akatsuki Department of Public Health, Kyorin University School of Medicine
Ohtsu, Tadahiro Department of Public Health, Showa University School of Medicine
Ishikawa, Mamoru Department of Public Health, Kyorin University School of Medicine
Matsunaga, Naomi Department of Public Health, Kyorin University School of Medicine
Karita, Kanae Department of Public Health, Kyorin University School of Medicine
Yoshida, Masao Department of Public Health, Kyorin University School of Medicine
Tanaka, Nobukazu Department of General Medicine, Kyorin University School of Medicine
Yamamoto, Minoru Department of General Medicine, Kyorin University School of Medicine
Hayashi, Junichi Department of General Medicine, Kyorin University School of Medicine
Takashima, Yutaka Department of Public Health, Kyorin University School of Medicine
Kitamoto, Kiyoshi Department of General Medicine, Kyorin University School of Medicine
抄録

Reduced nicotinamide adenine dinucleotide (NADH) dehydrogenase subunit 2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism, is reportedly associated with longevity in the Japanese population. The ND2-237Met genotype may exert resistance to atherogenic diseases, such as myocardial infarction or cerebrovascular disorders. To investigate whether ND2-237 Leu/Met polymorphism is associated with yearly changes in serum lipid levels, we conducted a longitudinal study of 107 healthy Japanese male subjects. Analysis of covariance revealed that the interaction between the ND2-237 Leu/Met genotypes and habitual drinking was significantly associated with yearly changes in serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC) levels (p0.036 and p0.006, respectively). In multiple regression analysis, daily drinking was significantly and positively associated with yearly changes in serum LDLC levels in men with ND2-237Met (p0.026). After adjusting for covariates, yearly changes in serum LDLC levels were significantly lower in non-daily drinkers with ND2-237Met than in those with ND2-237Leu (p0.047). These results suggest that ND2-237Met has a beneficial impact on yearly changes in serum LDLC in non-daily drinkers but not in daily drinkers.

キーワード
daily alcohol consumption
longevity
total cholesterol
low-density lipoprotein cholesterol
NADH dehydrogenase
Amo Type
Original Article
発行日
2009-12
出版物タイトル
Acta Medica Okayama
63巻
6号
出版者
Okayama University Medical School
開始ページ
331
終了ページ
338
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT