このエントリーをはてなブックマークに追加
ID 19270
Eprint ID
19270
フルテキストURL
Thumnail 70_3793.pdf 682 KB
タイトル(別表記)
Treatment of Experimental Tuberculosis with INAH Derivatives Part 3. Treatment of Experimental Tuberculosis in Mice with a Large Amount of INAH and its Derivatives
著者
山下 三代吉 岡山大学医学部平木内科教室
抄録
By administering a large amount of INAH, IHMS, INHG to the mice previously infected with INAH-10γ-resistant strain bacillus, the author obtained the following results: 1. In the macroscopic examinations at autopsy with respect to the effect of a large dose of INHA to the amount of 50 mg/kg given, although tubercles can be recognized, they are not so numerous, The decrement in the colonies in the tuberculous bacilli culture of the viscera proves to be as low as 1/10-1/20 the control, indicating a fairly good therapeutic effect of the drug. 2. The effect in the case given a large dose of 300 mg/kg IHMS or 500 mg/kg INHG does not differ so greatly from the administration of 50 mg/kg INAH. However, the fact that the mortality rate and the loss in average body weight are less than in the case given INAH seems to prove mild toxicity of these derivatives. 3. From the foregoing findings it is clear that a large dose of drugs in the INAH series adminstered to the mice previously infected with INAH-resistant strain bacillus is quite effective. 4. However, these results are quite inferior to those obtained in the case of the mice infected with INAH-susceptible strain bacillus. 5. As for the change in drug-resistance of tuberculous bacilli due to a large dose of drug, a rise in resistance was observed in a small portion of population, but on the whole no increase in the resistance could be recognized.
発行日
1958-10-31
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
70巻
10号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
3793
終了ページ
3801
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/70/10/70_10_3793/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma