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ID 32033
JaLCDOI
フルテキストURL
Thumnail fulltext.pdf 1.53 MB
著者
Wang, Jiang Ming Okayama University
Hayashi, Takeshi Okayama University
Zhang, Wen Ri Okayama University
Li, Feng Okayama University
Iwai, Masanori Okayama University
Abe, Koji Okayama University
抄録

In order to investigate a possible effect of insulin-like growth factor-1 (IGF-1) on ischemic brain injury, IGF-1 was applied topically on the brain surface of reperfused rat brain after 60 min of transient middle cerebral artery occlusion. In contrast to the cases treated with vehicle, the infarct volume was greatly reduced at 24 h of reperfusion by the treatment with IGF-1. Immunohistochemical analysis in the middle cerebral artery territory showed that Caspase-3 staining was markedly reduced in the cases with IGF-1 treatment, but 72-kDa heat shock protein staining remained almost unchanged. The present results suggest that treatment with IGF-1 exerts a significant effect on ameliorating brain injury after transient focal brain ischemia. Moreover, this effect is greatly associated with the reduction of Caspase-3 staining, but is only minimally associated with a decreasd stress response at the cellular level.

キーワード
caspase-3
cerebra? ischemia
72-KDa heat shock protein
Amo Type
Article
発行日
2001-02
出版物タイトル
Acta Medica Okayama
55巻
1号
出版者
Okayama University Medical School
開始ページ
25
終了ページ
30
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT