著者 Okada, Masahiro| Nakai, Akira| Hara Emilio, Satoshi| Taguchi, Tetsushi| Nakano, Takayoshi| Matsumoto, Takuya|
抄録 Over the past few years, the development of novel adhesives for biological soft tissue adhesion has gained significant interest. Such adhesives should be non-toxic and biocompatible. In this study, we synthesized a novel solid adhesive using nanostructured hydroxyapatite (HAp) and evaluated its physical adhesion properties through in vitro testing with synthetic hydrogels and mouse soft tissues. The results revealed that HAp-nanoparticle dispersions and HAp-nanoparticle-assembled nanoporous plates showed efficient adhesion to hydrogels. Interestingly, the HAp plates showed different adhesive properties depending upon the shape of their nanoparticles. The HAp plate made up of 17 nm-sized nanoparticles showed an adhesive strength 2.2 times higher than that of the conventional fibrin glue for mouse skin tissues.
キーワード Hydroxyapatite Nanoparticle Solid adhesive Wet adhesion
備考 2019年6月公開予定
発行日 2017-05
出版物タイトル Acta Biomaterialia
出版者 Elsevier B.V.
ISSN 1742-7061
NCID AA12033647
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
論文のバージョン author
PubMed ID 28483692
関連URL https://doi.org/10.1016/j.actbio.2017.05.014