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ID 16505
Eprint ID
16505
フルテキストURL
Thumnail 93_153.pdf 1.72 MB
タイトル(別表記)
Effect of different solutions for cold cardioplegia on myocardial injury and cardiac performance
著者
三好 康夫 岡山大学医学部第二外科教室
抄録
Cold cardioplegia has been appreciated as a superior method of myocardial protection, but the ideal coronary perfusate has not yet been established. In this study three types of solutions were tested as a coronary perfusate to choose the most suitable solution by comparing hemodynamics, enzymes and histology before and after clamping the aorta for 2 hours. In 6 canine hearts that were perfused with cold Ringer's solution (Group I), only one heart was able to be resuscitated and serum enzymes (GOT, LDH, CPK and CPK-MB) were prominently increased. Interstitial edema of the myocardium was severe histologically. In 9 hearts that were perfused with cold Collins' solution (Group II), 5 hearts were able to be resuscitated. The enzymes were all increased and myocardial interstitial edema was prominent. In 6 hearts that were arrested with cold Collins' solution and immediately thereafter perfused with cold Ringer's solution which contained 30 mEq/l of potassium (Group III), resuscitation was successful in all hearts. CPK-MB was not significantly increased and interstitial edema was mild. In Group I, myocardial dysfunction was thought to be due to anoxic injury. In Group II, the dysfunction was thought to be secondary to the excessively high concentration of potassium. In Group III, it was concluded that anoxic myocardial injury was prevented because cardiac arrest was maintained with 30 mEq/1 potassium and the injury due to the perfusate itself was also minimized because potassium concentration was lowered to 30 mEq/l and that the induced myocardial dysfunction was minimal.
キーワード
無酸素性心筋傷害
局所心筋冷却
カリウム濃度
心筋浮腫
発行日
1981-02-28
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
93巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
153
終了ページ
164
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/93/1-2/93_1-2_153/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma