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ID 16618
Eprint ID
16618
フルテキストURL
93_643.pdf 2.41 MB
タイトル(別表記)
Enzymological studies on rheumatoid arthritis. 1. Studies on collagenase and monoamine-oxidase activities in patients with rheumatoid arthritis
著者
戸田 俊介 岡山大学医学部第三内科
抄録
We assayed the activities of collagenase and monoamine-oxidase (MAO) in the fluid of the patients with rheumatoid arthritis (RA) and examined the relationship between collagenase, MAO activities and the grade of joint inflammation. The mean collagenase value of RA patients was significantly higher than that of osteoarthritis (OA) patients. A significant positive correlation was present between collagenase activity, leukocyte counts, and beta-glucuronidase activity in RA synovial fluid. These indices are considered to be parameters of the grade of joint inflammation. There was no correlation between collagenase activity, erythrocyte sedimentation rate (ESR), gamma-globulin level, C-reactive protein (CRP), rheumatoid factor, acid-phosphatase activity and the stage of RA (grade of joint destruction). The mean MAO value of RA synovial fluid was significantly higher than that of OA synovial fluid. The mean activity of the group of patients whose CRP values were below two positive was significantly higher than that of the group of patients whose CRP values were over two positive. The mean MAO activity in stage 3 or 4 group was significantly higher than that in stage 1 or 2. These findings suggest that collagenase activity is intimately correlated with the grade of local Inflammation in RA and that the MAO activity is closely correlated with the grade of joint fibrosis.
キーワード
慢性関節リウマチ
コラゲナーゼ活性
モノアミンオキシダーゼ活性
発行日
1981-08-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
93巻
7-8号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
643
終了ページ
656
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/93/7-8/93_7-8_643/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma