JaLCDOI 10.18926/AMO/30479
フルテキストURL fulltext.pdf
著者 Mizutani, Hitoshi| Hayashi, Tatsuya| Nouchi, Nobuhiro| Inachi, Shin| Suzuki, Koji| Shimizu, Masayuki|
抄録 <p>To clarify the relation between systemic and cutaneous vascular endothelial injury in progressive systemic sclerosis (PSS), we examined thrombomodulin (TM) expression in PSS skin lesions immuno-histopathologically and compared it with plasma soluble TM levels measured by specific enzyme-linked immunosorbent assay. The plasma soluble TM level in PSS patients was significantly higher than that of normal controls and was as high as the levels of SLE patients. In relation to disease activities, the plasma TM levels of sclerotic phase PSS patients were significantly higher than that of atrophic phase PSS patients. The plasma samples with anti-Scl-70 antibody showed a high TM level than samples with anti-centromere antibody or anti-RNP antibody. Barnett's types or systemic corticosteroid treatment did not affect the TM level. Histopathologically, the dermal endothelial TM expression significantly increased in the sclerotic skin and moderately increased in the non-sclerotic skin of PSS compared with that of normal control skin. In addition, immunoreactive TM expression in the epidermis also increased in PSS. Disease activity-dependent elevation of plasma TM levels and immuno-histopathological expression of TM suggested generalized endothelial and epidermal cell involvement in PSS, and compensation in part by overproduction of TM by endothelial cells.</p>
キーワード thrombomodulin scleroderma skin endothelial cells keratinocyte
Amo Type Article
発行日 1996-12
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 293
終了ページ 297
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8985465
Web of Science KeyUT A1996WA04500002