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ID 16261
Eprint ID
16261
フルテキストURL
95_111.pdf 621 KB
タイトル(別表記)
Effects of salicylamide on absorption, distribution, metabolism and excretion of amobarbital and pentobarbital
著者
箭内 博行 岡山大学医学部脳代謝研究施設機能生化学部門 ORCID publons researchmap
抄録
Effects of simultaneously administered salicylamide (SAM) on absorption, distribution, metabolism and excretion of amobarbital (AMB) and pentobarbital (PEB) were studied. Absorption of AMB from the stomach was depressed by simultaneously administered SAM, but absorption of PEB was not affected by SAM. Absorption of either of them from the small intestines was not affected by the administration of SAM. Movement of AMB or PEB to blood, brain, kidney and liver was markedly depressed by the administration of SAM. Intraveneous injection of AMB or PEB after intraperitoneal injection of SAM increased the blood level of AMB and PEB. The excretory rate of AMB into urine was decreased, and the quantity excreted in 24hours was increased by the administration of SAM. On the other hand, SAM decreased the excretory quantity of PEB, but it did not affect its excretory rate. Decomposition of AMB and PEB in the supernatant fraction of liver after centrifugation at 9,000 x g was markedly inhibited by SAM. Binding of AMB and PEB to bovine serum albumin was also inhibited by the administration of SAM. The administration of SAM did not have any effect on their partition coefficients.
キーワード
アモバルビタール
ペントバルビタール
サリチラマイド
薬物併用
発行日
1983-02-28
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
95巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
111
終了ページ
123
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/95/1-2/95_1-2_111/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma