JaLCDOI 10.18926/AMO/55204
フルテキストURL 71_3_219.pdf
著者 Takakura, Hiroaki| Domae, Shohei| Ono, Toshiro| Sasaki, Akira|
抄録  Anticancer drugs induce cell-cycle arrest and apoptosis not only in tumor cells, but also in immune cells. However, many preclinical and clinical findings show that some chemotherapeutic agents can improve the antitumor efficacy of immunotherapy. We immunohistochemically analyzed the degree of immune cell infiltration and the relevance of programmed cell death 1 ligand-1 (PD-L1) expression in surgically resected oral squamous cell carcinoma (OSCC) specimens from patients who had undergone pretreatment with certain chemotherapies and other patients without pretreatment. We divided the patients into the group of neoadjuvant chemotherapy (NAC) patients (n=8) and the nNAC (without NAC) patient group (n=10). We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment. Decreased numbers of Tregs and PD-1-positive cells were observed in the NAC group. No significant difference was observed in the degree of immune-cell infiltration between the patient groups except for CD56 NK cells in the stroma and PD-1 cells in cancer nests. Eighty percent of the nNAC specimens showed intermediate-to-strong PD-L1 protein expression, whereas 75% of the NAC specimens showed down-regulation of the PD-L1 protein, indicating the effectiveness of the chemotherapeutic treatment before surgery.
キーワード oral squamous cell carcinoma programmed cell death 1 ligand-1 tumor microenvironment neoadjuvant chemotherapy immunohistochemistry
Amo Type Original Article
発行日 2017-06
出版物タイトル Acta Medica Okayama
71巻
3号
出版者 Okayama University Medical School
開始ページ 219
終了ページ 226
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 28655941
JaLCDOI 10.18926/AMO/54506
フルテキストURL 70_4_291.pdf
著者 Yoshioka, Norie| Shimo, Tsuyoshi| Ibaragi, Soichiro| Sasaki, Akira|
抄録 Temporomandibular joint (TMJ) dislocation can occur during daily activities and negatively affect a patientʼs quality of life. Although both nonsurgical and surgical techniques have been used to treat recurrent TMJ dislocation, the former is not always successful and the latter, although having a high success rate, is invasive and requires hospitalization. Recently, autologous blood injection has been used to treat recurrent TMJ dislocation. However, this technique is not yet widely used in clinical practice. We designed this study to obtain further information as to efficacy, safety and stability of autologous blood injection for recurrent TMJ dislocation.
キーワード autologous blood injection recurrent temporomandibular joint dislocation
Amo Type Clinical Study Protocols
発行日 2016-08
出版物タイトル Acta Medica Okayama
70巻
4号
出版者 Okayama University Medical School
開始ページ 291
終了ページ 294
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27549675
Web of Sience KeyUT 000384748600010
著者 山中 玲子| 曽我 賢彦| 縄稚 久美子| 柳 文修| 兒玉 直紀| 中田 貴| 三浦 留美| 羽川 操| 竹内 哲男| 山根 美榮子| 森田 学| 高柴 正悟| 浅海 淳一| 皆木 省吾| 吉山 昌宏| 下野 勉| 窪木 拓男| 佐々木 朗| 森田 潔|
発行日 2009-06
出版物タイトル 岡山歯学会雑誌
28巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/49257
フルテキストURL 67_1_55.pdf
著者 Shimo, Tsuyoshi| Nishiyama, Akiyoshi| Jinno, Tokiari| Sasaki, Akira|
抄録 In this article, we report the successful surgical treatment of a patient, 34 years of age, who had a severe gummy smile and a class II malocclusion. The patient had an 11-mm gingival exposure during full smile and a convex profile. A LeFort I osteotomy combined with a horseshoe osteotomy was used for the superior repositioning of the maxilla;then, an intraoral vertical ramus osteotomy (IVRO) and genioplasty were performed for mandibular advancement. The maxilla was acceptably impacted 8mm at the first incisor and 5mm at the first molar. Both the occlusion and facial appearance were significantly improved by this surgical-orthodontic treatment. Our results suggest that the combination of a horseshoe osteotomy with a LeFort I osteotomy is a useful technique for reliable superior repositioning of the maxilla.
キーワード LeFort I osteotomy horseshoe osteotomy gummy smile
Amo Type Case Report
発行日 2013-02
出版物タイトル Acta Medica Okayama
67巻
1号
出版者 Okayama University Medical School
開始ページ 55
終了ページ 60
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23439509
Web of Sience KeyUT 000316829900007
著者 Fujioka, Shinsuke| Nishimura, Hiroaki| Nishihara, Katsunobu| Sasaki, Akira| Sunahara, Atsushi| Okuno, Tomoharu| Ueda, Nobuyoshi| Ando, Tsuyoshi| Tao, Yezheng| Shimada, Yoshinori| Hashimoto, Kazuhisa| Yamaura, Michiteru| Shigemori, Keisuke| Nakai, Mitsuo| Nagai, Keiji| Norimatsu, Takayoshi| Nishikawa, Takeshi| Miyanaga, Noriaki| Izawa, Yasukazu| Mima, Kunioki|
発行日 2005-11
出版物タイトル Physical Review Letters
95巻
23号
資料タイプ 学術雑誌論文
著者 松葉谷 治| 酒井 均| 上田 晃| 堤 真| 日下部 実| 佐々木 昭|
発行日 1978-03-25
出版物タイトル 岡山大学温泉研究所報告
47巻
資料タイプ 紀要論文
著者 松葉谷 治| 酒井 均| 日下部 実| 佐々木 昭|
発行日 1980-03-25
出版物タイトル 岡山大学温泉研究所報告
50巻
資料タイプ 紀要論文
著者 佐々木 朗|
発行日 1990-10-31
出版物タイトル
資料タイプ 学位論文