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ID 30488
JaLCDOI
フルテキストURL
著者
Kobayashi, Kazuko Okayama University
Han, Mei Okayama University
Watarai, Shinobu Okayama Univeristy
Yasuda, Tatsuji Okayama University
抄録

<P>Phospholipid vesicles, also known as liposomes, were examined for their ability to act as a drug carrier to the brain. 9-Amino-1,2,3,4-tetrahydroacridine (THA), a centrally acting acetylcholinesterase inhibitor, was used as a model drug. THA was encapsulated in dehydration-rehydration vesicles (DRV) composed of egg yolk phosphatidylcholine, cholesterol and dipalmitoyl-phosphatidic acid (molar ratio, 10/10/1) and injected into the heart of mice. The toxicity and side effects of THA were reduced by encapsulation in liposomes. The THA concentration in the mouse brain after injection of THA-encapsulated DRV at a dose of 2 mg/kg remained higher than that of free THA at the same dose. Effective concentration of THA in the brain was also prolonged by the use of liposomes, although accumulation of THA in the spleen and kidney was observed. We, therefore, concluded that liposomes are useful as carriers of drugs to the brain.</P>

キーワード
brain targeting
liposomes
mouse
THA(9-amino-1
2
3
4
-tetrahydroacridin)
Amo Type
Article
発行日
1996-04
出版物タイトル
Acta Medica Okayama
50巻
2号
出版者
Okayama University Medical School
開始ページ
67
終了ページ
72
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT