JaLCDOI 10.18926/AMO/57946
フルテキストURL 74_1_1.pdf
著者 Chen, Yuehua| Ohara, Toshiaki| Xing, Boyi| Qi, Jiping| Noma, Kazuhiro| Matsukawa, Akihiro|
抄録 Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review, we summarize the roles of iron in cancer cells and CSCs. We also summarize anti-cancer therapeutic studies with iron chelators and describe our expectation of a new therapeutic strategy for CSCs on the basis of our findings.
キーワード cancer stem cell stemness iron chelation chemotherapy
Amo Type Review
発行日 2020-02
出版物タイトル Acta Medica Okayama
74巻
1号
出版者 Okayama University Medical School
開始ページ 1
終了ページ 6
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32099242
著者 Seno, Akimasa| Murakami, Chikae| El‑Aarag, Bishoy| Iwasaki, Yoshiaki| Ohara, Toshiaki| Seno, Masaharu|
キーワード cancer stem cell conditioned medium mouse embryonic stem cells
発行日 2019-09
出版物タイトル Oncology Letters
18巻
3号
出版者 Spandidos Publications
開始ページ 2756
終了ページ 2762
ISSN 1792-1074
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © Seno et al.
論文のバージョン publisher
PubMed ID 31452753
DOI 10.3892/ol.2019.10614
Web of Science KeyUT 000487675500075
関連URL isVersionOf https://doi.org/10.3892/ol.2019.10614
著者 Ieda, Takeshi| Tazawa, Hiroshi| Okabayashi, Hiroki| Yano, Shuya| Shigeyasu, Kunitoshi| Kuroda, Shinji| Ohara, Toshiaki| Noma, Kazuhiro| Kishimoto, Hiroyuki| Nishizaki, Masahiko| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Saitou, Takashi| Imamura, Takeshi| Fujiwara, Toshiyoshi|
発行日 2019-11-8
出版物タイトル Scientific Reports
9巻
出版者 Nature Publishing Group
開始ページ 16378
ISSN 2045-2322
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2019
論文のバージョン publisher
PubMed ID 31705021
DOI 10.1038/s41598-019-52816-z
Web of Science KeyUT 000495372900001
関連URL isVersionOf https://doi.org/10.1038/s41598-019-52816-z
フルテキストURL cancers_11_2_177.pdf
著者 Katsura, Yuki| Ohara, Toshiaki| Noma, Kazuhiro| Ninomiya, Takayuki| Kashima, Hajime| Kato, Takuya| Sato, Hiroaki| Komoto, Satoshi| Narusaka, Toru| Tomono, Yasuko| Xing, Boyi| Chen, Yuehua| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kasai , Tomonari| Seno, Masaharu| Matsukawa, Akihiro| Fujiwara, Toshiyoshi|
キーワード cancer stem cells combination therapy iron stemness
発行日 2019-02-03
出版物タイトル Cancers
11巻
2号
出版者 MDPI
開始ページ 177
ISSN 2072-6694
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2019 by the authors
論文のバージョン publisher
PubMed ID 30717462
DOI 10.3390/cancers11020177
Web of Science KeyUT 000460747200051
関連URL isVersionOf https://doi.org/10.3390/cancers11020177
著者 Matsumoto, Kazuyuki| Ohara, Toshiaki| Fujisawa, Masayoshi| Takaki, Akinobu| Takahara, Masahiro| Tanaka, Noriyuki| Kato, Hironari| Horiguchi, Shigeru| Yoshida, Ryuichi| Umeda, Yuzo| Fushimi, Soichiro| Yagi, Takahito| Matsukawa, Akihiro| Okada, Hiroyuki|
キーワード Immunohistochemistry PD-L1 Pancreatic cancer
備考 This fulltext will be available in Apr 2020|
発行日 2019-04-29
出版物タイトル Journal of Gastroenterology
54巻
11号
開始ページ 1019
終了ページ 1028
ISSN 09441174
NCID AA10988015
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 31032528
DOI 10.1007/s00535-019-01586-6
Web of Science KeyUT 000492169400008
関連URL isVersionOf https://doi.org/10.1007/s00535-019-01586-6
JaLCDOI 10.18926/AMO/54421
フルテキストURL 70_3_213.pdf
著者 Kikuchi, Satoru| Kagawa, Shunsuke| Ohara, Toshiaki| Kubota, Tetsushi| Kuwada, Kazuya| Kagawa, Tetsuya| Kuroda, Shinji| Shirakawa, Yasuhiro| Nishizaki, Masahiko| Fujiwara, Toshiyoshi|
抄録 A 69-year-old man underwent endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) at the lesser curvature in the angle of stomach. Histological examination revealed tub1, pM, ly0, v0, pLM(-), pVM(-), and the resection was considered curative. The scar after ESD was followed by esophagogastroduodenoscopy (EGD) and biopsy. Twenty months later, EGD showed an ulcerative lesion in the vicinity of the ESD scar, and histological examination of the biopsy specimen showed adenocarcinoma. A distal gastrectomy with lymph node dissection was then performed. Postoperative pathology showed tub1, pM, pN0, ly0, v0, and Stage 1A. Skip lesions were seen in the specimen resected by ESD, and the histological review confirmed so-called “dysplasia-like atypia” (DLA) between the lesions. It has been reported recently that in DLA, the dysplasia-like change involves only the bases of the pits, without upper pit or surface epithelium involvement, and it is said that the rate of DLA is higher in gastric cancer patients. We speculated that a precancerous lesion close to the resected cancer developed into a local recurrence.
キーワード dysplasia-like atypia early gastric cancer endoscopic submucosal dissection local recurrence
Amo Type Case Report
発行日 2016-06
出版物タイトル Acta Medica Okayama
70巻
3号
出版者 Okayama University Medical School
開始ページ 213
終了ページ 216
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27339211
Web of Science KeyUT 000379406100009
著者 大原 利章| 櫻間 教文| 唐井 利昌|
出版物タイトル
資料タイプ その他
JaLCDOI 10.18926/AMO/53524
フルテキストURL 69_3_173.pdf
著者 Shirakawa, Yasuhiro| Noma, Kazuhiro| Ohara, Toshiaki| Kashima, Hajime| Maeda, Naoaki| Tanabe, Shunsuke| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
抄録 A chyle leak can occur as a complication after neck or chest surgery. Such a leak prolongs the hospital stay and is sometimes life-threatening. The treatment options are conservative management, interventional radiologic embolization, and surgery. Thoracoscopic ligation of the thoracic duct has emerged as a promising and definitive treatment. The case of a 65-year-old Japanese male patient with a rare congenital right aortic arch (typeⅢB1 of Edwardʼs classification) and a severe chyle leak that occurred after a total pharyngolaryngo-esophagectomy (TPLE) is described. The chyle leak was successfully managed by thoracoscopic ligation of the thoracic duct via a left-side approach with the patient in the prone position.
キーワード chyle leak thoracic duct thoracoscopy prone position
Amo Type Case Report
発行日 2015-06
出版物タイトル Acta Medica Okayama
69巻
3号
出版者 Okayama University Medical School
開始ページ 173
終了ページ 176
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 26101193
Web of Science KeyUT 000356903000006