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ID 52037
フルテキストURL
著者
Shinaoka, Akira Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Human Morphol
Momota, Ryusuke Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Human Morphol
Shiratsuchi, Eri Hayashikane Sangyo Co Ltd, Div Res & Dev
Kosaka, Mitsuko Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Human Morphol
Kumagishi, Kanae Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Human Morphol
Nakahara, Ryuichi Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Orthopaed Surg
Naito, Ichiro Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Human Morphol
Ohtsuka, Aiji Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Human Morphol
抄録
Most blood vessels contain elastin that provides the vessels with the resilience and flexibility necessary to control hemodynamics. Pathophysiological hemodynamic changes affect the remodeling of elastic components, but little is known about their structural properties. The present study was designed to elucidate, in detail, the three-dimensional (3D) architecture of delicate elastic fibers in small vessels, and to reveal their architectural pattern in a rat model. The fine vascular elastic components were observed by a newly developed scanning electron microscopy technique using a formic acid digestion with vascular casts. This method successfully visualized the 3D architecture of elastic fibers in small blood vessels, even arterioles and venules. The subendothelial elastic fibers in such small vessels assemble into a sheet of meshwork running longitudinally, while larger vessels have a higher density of mesh and thicker mesh fibers. The quantitative analysis revealed that arterioles had a wider range of mesh density than venules; the ratio of density to vessel size was higher than that in venules. The new method was useful for evaluating the subendothelial elastic fibers of small vessels and for demonstrating differences in the architecture of different types of vessels.
キーワード
vascular corrosion casting
elastic fiber
elastin
SEM
formic acid digestion
rat
three-dimensional architecture
発行日
2013-04
出版物タイトル
Microscopy and Microanalysis
19巻
2号
開始ページ
406
終了ページ
414
ISSN
1431-9276
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.1017/S1431927612014341
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/51967
言語
English
論文のバージョン
publisher
査読
有り
DOI
Web of Sience KeyUT