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ID 32803
JaLCDOI
フルテキストURL
著者
yamane, Takashi Okayama University
Matsuo, Toshihiko Okayama University ORCID Kaken ID
Hasebe, Satoshi Okayama University
Ohtsuki, Hiroshi Okayama University
抄録

The purpose of this study was to elucidate the role of extracellular matrix components such as aggrecan, fibronectin, and laminin in the extraocular muscle of patients with strabismus. Resected tissues of the medial rectus muscle of 47 patients with intermittent exotropia obtained during recession-resection surgery were frozen under liquid nitrogen and pulverized by a Freezer/Mill to solubilize the tissue for enzyme immunoassay. The total amounts of aggrecan, fibronectin, and laminin in the resected tissue were correlated with clinical data of patients such as age, exodeviation, and refractive error. The amount of aggrecan decreased significantly with the advance of age (P < 0.0001, Spearman rank correlation test), while the amount of laminin or fibronectin had no correlation with age. Patients with basic type intermittent exotropia showed larger, although not significantly, amounts of aggrecan than those with convergence insufficiency type (P = 0.0538, Mann-Whitney U-test). The amount of aggrecan may be related to motor aspects of intermittent exotropia.

キーワード
extraocular muscle
aggrecan
laminin
fibronectin
intermittent extropia
Amo Type
Article
発行日
2003-08
出版物タイトル
Acta Medica Okayama
57巻
4号
出版者
Okayama University Medical School
開始ページ
199
終了ページ
204
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT