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ID 30380
JaLCDOI
フルテキストURL
著者
Haque, Mahmudul Okayama University
Hirai, Yoshikazu Okayama University
Yokota, Kenji Okayama University
Oguma, Keiji Okayama University Kaken ID researchmap
抄録

Many of Helicobacter species have been found to have novel cholesteryl glucosides (CGs). To study the biosynthetic mechanism of CGs, the lipid profiles of H. pylori and H. mustelae grown in serum-supplemented and cholesterol-restricted serum-free media were investigated. In contrast to the serum-supplemented state, helicobacters had less CGs in the serum-free state; a trace amount of CGs and no CG was detected in H. pylori and H. mustelae, respectively. The proportion of total and individual phospholipid also showed significant alteration. Unknown lipids which did not contain phosphate and sugar were detected in the serum-free state, but not in the serum-supplemented state. The CGs were found to be distributed mainly in the membrane fractions, and one of the unknown lipids was found exclusively in the cytosol fraction. Based on these data, it is apparent that the CGs of helicobacters are synthesized by de novo uptake of cholesterol from the media. The unknown lipids detected in the serum-free state may be storage lipids, appearing in response to depletion of nutrients, especially cholesterol, or other factors in the media.

キーワード
Helicobacter
steryl glycoside
cholesteryl glucoside
Amo Type
Article
発行日
1995-08
出版物タイトル
Acta Medica Okayama
49巻
4号
出版者
Okayama University Medical School
開始ページ
205
終了ページ
211
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT