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ID 40129
JaLCDOI
フルテキストURL
Thumnail 64_4_219.pdf 1.62 MB
著者
Doi, Maho Department of Pharmaceutical Care and Health Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Miyazaki, Ikuko Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nagamachi, Tomoko Department of Pharmacy, Okayama University Hospital
Shinomiya, Kazuaki Department of Pharmaceutical Care and Health Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Matsunaga, Hisashi Department of Pharmacy, Okayama University Hospital
Sendo, Toshiaki Department of Pharmacy, Okayama University Hospital
Kawasaki, Hiromu Department of Clinical Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Asanuma, Masato Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Gomita, Yutaka Shujitsu University School of Pharmacy
Kitamura, Yoshihisa Department of Pharmaceutical Care and Health Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
抄録
We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH.
キーワード
ACTH
imipramine
lithium
proliferation
Ki-67
Amo Type
Original Article
発行日
2010-08
出版物タイトル
Acta Medica Okayama
64巻
4号
出版者
Okayama University Medical School
開始ページ
219
終了ページ
223
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT