JaLCDOI 10.18926/AMO/48264
フルテキストURL 66_2_143.pdf.pdf
著者 Watanabe, Makiko| Ueno, Hiroshi| Suemitsu, Shunsuke| Yokobayashi, Eriko| Matsumoto, Yosuke| Usui, Shinichi| Sujiura, Hiroko| Okamoto, Motoi|
抄録 Recent studies have demonstrated the important role of immune molecules in the development of neuronal circuitry and synaptic plasticity. We have detected the presence of FcγRllB protein in parvalbumin- containing inhibitory interneurons (PV neurons). In the present study, we examined the appearance of PV neurons in the barrel cortex and the effect of sensory deprivation in FcγRllB-deficient mice (FcγRllB-/-) and wild-type mice. There was no substantial difference in the appearance of PV neurons in the developing barrel cortex between FcγRllB-/- and wild-type mice. Sensory deprivation from immediately after birth (P0) or P7 to P12-P14 induced an increase in PV neurons. In contrast, sensory deprivation from P7 or P14 to P28, but not from P21 to P28, decreased PV neurons in wild-type mice. However, sensory deprivation from P0 or P7 to P12-P14 did not increase PV neurons and sensory deprivation from P7 or P14 to P28 did not decrease or only modestly decreased PV neurons in FcγRllB-/- mice. The results indicate that expression of PV is regulated by sensory experience and the second and third postnatal weeks are a sensitive period for sensory deprivation, and suggest that FcγRllB contributes to sensory experience-regulated expression of PV.
キーワード parvalbumin fast-spiking interneurons FcγRllB barrel cortex sensory deprivation
Amo Type Original Article
発行日 2012-04
出版物タイトル Acta Medica Okayama
66巻
2号
出版者 Okayama University Medical School
開始ページ 143
終了ページ 154
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 22525472
Web of Sience KeyUT 000303175300007
著者 Ono, Takehiro| Tsuji, Tomoe| Sakai, Miho| Yukizaki, Chizuko| Ino, Hisatoshi| Akagi, Isao| Hiramatsu, Kaori| Matsumoto, Yohsuke| Sugiura, Yoshihiro| Uto, Hirofumi| Tsubouchi, Hirohito| Gohda, Eiichi|
発行日 2009-04
出版物タイトル Cytokine
46巻
1号
資料タイプ 学術雑誌論文
著者 松本 洋介|
発行日 2008-03-25
出版物タイトル
資料タイプ 学位論文
著者 松本 洋輔|
発行日 1997-03-25
出版物タイトル
資料タイプ 学位論文