著者 松尾 俊彦|
発行日 2015-03
出版物タイトル Okayama University Medical Research Updates
8巻
資料タイプ その他
タイトル(別表記) Investigator (doctor)-initiated clinical trial of photoelectric dye-coupled thin film (Okayama University-type) retinal prosthesis
フルテキストURL 127_223.pdf
著者 松尾 俊彦| 内田 哲也|
キーワード 人工網膜 OUReP 医師主導治験 色素結合薄膜 網膜色素変性
備考 特集(Feature Articles)
出版物タイトル 岡山医学会雑誌
発行日 2015-12-01
127巻
3号
出版者 岡山医学会
出版者(別表記) Okayama Medical Association
開始ページ 223
終了ページ 229
ISSN 0030-1558
NCID AN00032489
資料タイプ 学術雑誌論文
関連URL isVersionOf https://doi.org/10.4044/joma.127.223
言語 Japanese
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
査読 有り
DOI 10.4044/joma.127.223
NAID 130005116816
Sort Key 10
Eprints Journal Name joma
参考文献 1) Ho AC, Humayun MS, Dorn JD, da Cruz L, Dagnelie G, Handa J, Barale PO, Sahel JA, Stanga PE, Hafezi F, Safran AB, Salzmann J, et al. ; Argus II Study Group : Long-Term Results from an Epiretinal Prosthesis to Restore Sight to the Blind. Ophthalmology (2015) 122, 1547-1554. 2) 松尾俊彦 : 光電変換色素を使った人工網膜試作品の開発. 岡山大学方式の人工網膜. 「眼科における最新医工学. Ⅱ. 視機能再生工学」. 臨床眼科 増刊号 (2005) 59, S118-122. 3) 松尾俊彦 : 岡山大学方式の人工網膜の試作品. 光電変換色素をポリエチレン・フィルムに固定した人工網膜の開発. 「特集 : 医療と画像処理」. 画像ラボ (2006) 17, 36-40. 4 松尾俊彦 : 視機能再生工学. 光電変換色素をポリエチレン・フィルムに固定した人工網膜(岡山大学方式人工網膜)の開発. 「特集 : 最近注目される脳神経疾患治療の研究」. Brain and Nerve (2007) 59, 331-338. 5) Matsuo T, Uchida T, Takarabe K : Safety, efficacy, and quality control of a photoelectric dye-based retinal prosthesis (Okayama University-type retinal prosthesis) as a medical device. J Artif Organs (2009) 12, 213-225. 6) 内田哲也, 松尾俊彦 : 色素固定薄膜型人工網膜(岡山大学方式人工網膜)の実用化に向けた医工連携の取り組み. 「大学発ー次世代を担うR&D特集」. 機能材料 (2014) 34, 41-47. 7) 松尾俊彦, 内田哲也 : 色素結合薄膜型の人工網膜(OURePTM)の医師主導治験を目指して. 「特集 : 人工臓器―最近の進歩」. 人工臓器 (2014) 43, 189-193. 8) Matsuo T : A simple method for screening photoelectric dyes towards their use for retinal prostheses. Acta Med Okayama (2003) 57, 257-260. 9) Matsuo T, Dan-oh Y, Suga S (Inventors), Okayama University (Assignee) : Agent for inducing receptor potential. United States Patent. Patent No. US 7,101,533 B2. Date of Patent September 5, 2006. 10) 松尾俊彦, 段王保文, 菅 貞治(発明者), 岡山大学(特許権者) : 受容器電位誘発剤のための有機色素化合物のスクリーニング方法. 特許第5090431号. 登録日2012年9月21日. 11) Uchida T, Ishimaru S, Shimamura K, Uji A, Matsuo T, Ohtsuki H : Immobilization of photoelectric dye on the polyethylene film surface. Memoirs of the Faculty of Engineering Okayama University (2005) 39, 16-20. 12) Uji A, Matsuo T, Ishimaru S, Kajiura A, Shimamura K, Ohtsuki H, Dan-oh Y, Suga S : Photoelectric dye-coupled polyethylene film as a prototype of retinal prostheses. Aritif Organs (2005) 29, 53-57. 13) Uji A, Matsuo T, Uchida T, Shimamura K, Ohtsuki H : Intracellular calcium response and adhesiveness of chick embryonic retinal neurons to photoelectric dye-coupled polyethylene films as prototypes of retinal prostheses. Artif Organs (2006) 30, 695-703. 14) Tamaki T, Matsuo T, Hosoya O, Tsutsui KM, Uchida T, Okamoto K, Uji A, Ohtsuki H : Glial reaction to photoelectric dye-based retinal prostheses implanted in the subretinal space of rats. J Artif Organs (2008) 11, 38-44. 15) Okamoto K, Matsuo T, Tamaki T, Uji A, Ohtsuki H : Short-term biological safety of a photoelectric dye used as a component of retinal prostheses. J Artif Organs (2008) 11, 45-51. 16) Alamusi, Matsuo T, Hosoya O, Tsutsui KM, Uchida T : Behavior tests and immunohistochemical retinal response analyses in RCS rats with subretinal implantation of Okayama University-type retinal prosthesis. J Artif Organs (2013) 16, 343-351. 17) Alamusi, Matsuo T, Hosoya O, Tsutsui KM, Uchida T : Vision maintenance and retinal apoptosis reduction in RCS rats with Okayama University-type retinal prosthesis (OURePTM) implantation. J Artif Organs (2015) 17, [Epub ahead of print]. 18) Matsuo T, Morimoto N : Visual acuity and perimacular retinal layers detected by optical coherence tomography in patients with retinitis pigmentosa. Br J Ophthalmol (2007) 91, 888-890. 19) Tamaki M, Matsuo T : Optical coherence tomographic parameters as objective signs for visual acuity in patients with retinitis pigmentosa, future candidates for retinal prostheses. J Artif Organs (2011) 14, 140-150. Erratum (2011) 14, 385.
著者 Kawata, Tetsuhiro| Matsuo, Toshihiko| Uchida, Tetsuya|
発行日 2014-06-25
出版物タイトル SpringerPlus
3巻
資料タイプ 学術雑誌論文
著者 Aoba, Kana| Matsuo, Toshihiko| Hamasaki, Ichiro| Hasebe, Kayoko|
発行日 2015-04-07
出版物タイトル SpringerPlus
4巻
資料タイプ 学術雑誌論文
著者 Matsuo, Toshihiko|
発行日 2014-07-16
出版物タイトル SpringerPlus
3巻
資料タイプ 学術雑誌論文
著者 Matsuo, Toshihiko|
発行日 2015-09-21
出版物タイトル SpringerPlus
4巻
資料タイプ 学術雑誌論文
著者 Matsuo, Toshihiko|
発行日 2015-08-28
出版物タイトル SpringerPlus
4巻
資料タイプ 学術雑誌論文
著者 Alamusi| Matsuo, Toshihiko| Hosoya, Osamu| Tsutsui, Kimiko M.| Uchida, Tetsuya|
発行日 2013-09
出版物タイトル Journal of Artificial Organs
16巻
3号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/50411
フルテキストURL 67_3_177.pdf
著者 Matsuo, Toshihiko| Yamasaki, Hanako| Yasuhara, Hirotaka| Hasebe, Kayoko|
抄録 To test the effect of double vision on postural stability, we measured postural stability by electric stabilometry before prism-wearing and immediately, 15, 30, and 60min after continuous prism-wearing with 6 prism diopters in total (a 3-prism-diopter prism placed with the base up in front of one eye and with the base down in front of the other eye) in 20 normal adult individuals with their eyes open or closed. Changes in stabilometric parameters in the time course of 60min were analyzed statistically by repeated-measure analysis of variance. When subjectsセ eyes were closed, the total linear length (cm) and the unit-time length (cm/sec) of the sway path were significantly shortened during the 60-minute prism-wearing (p<0.05). No significant change was noted in any stabilometric parameters obtained with the eyes open during the time course. In conclusion, postural stability did not change with the eyes open in the condition of large vertical diplopia, induced by prism-wearing for 60min, while the stability became better when measured with the eyes closed. A postural control mechanism other than that derived from visual input might be reinforced under abnormal visual input such as non-fusionable diplopia.
キーワード body sway postural stability (postural control) stabilometry prism vertical diplopia
Amo Type Original Article
発行日 2013-06
出版物タイトル Acta Medica Okayama
67巻
3号
出版者 Okayama University Medical School
開始ページ 177
終了ページ 183
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23804141
Web of Sience KeyUT 000320747900007
JaLCDOI 10.18926/AMO/49666
フルテキストURL 67_2_87.pdf
著者 Matsuo, Toshihiko| Takeda, Yoshimasa| Ohtsuka, Aiji|
抄録 The purpose of this study was to develop a series of stereoscopic anatomical images of the eye and orbit for use in the curricula of medical schools and residency programs in ophthalmology and other specialties. Layer-by-layer dissection of the eyelid, eyeball, and orbit of a cadaver was performed by an ophthalmologist. A stereoscopic camera system was used to capture a series of anatomical views that were scanned in a panoramic three-dimensional manner around the center of the lid fissure. The images could be rotated 360 degrees in the frontal plane and the angle of views could be tilted up to 90 degrees along the anteroposterior axis perpendicular to the frontal plane around the 360 degrees. The skin, orbicularis oculi muscle, and upper and lower tarsus were sequentially observed. The upper and lower eyelids were removed to expose the bulbar conjunctiva and to insert three 25-gauge trocars for vitrectomy at the location of the pars plana. The cornea was cut at the limbus, and the lens with mature cataract was dislocated. The sclera was cut to observe the trocars from inside the eyeball. The sclera was further cut to visualize the superior oblique muscle with the trochlea and the inferior oblique muscle. The eyeball was dissected completely to observe the optic nerve and the ophthalmic artery. The thin bones of the medial and inferior orbital wall were cracked with a forceps to expose the ethmoid and maxillary sinus, respectively. In conclusion, the serial dissection images visualized aspects of the local anatomy specific to various procedures, including the levator muscle and tarsus for blepharoptosis surgery, 25-gauge trocars as viewed from inside the eye globe for vitrectomy, the oblique muscles for strabismus surgery, and the thin medial and inferior orbital bony walls for orbital bone fractures.
キーワード stereoscopic camera-captured images education local anatomical dissection orbit eye
Amo Type Original Article
発行日 2013-04
出版物タイトル Acta Medica Okayama
67巻
2号
出版者 Okayama University Medical School
開始ページ 87
終了ページ 91
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23603924
Web of Sience KeyUT 000317801700002
JaLCDOI 10.18926/AMO/49046
フルテキストURL 66_6_493.pdf
著者 Matsuo, Toshihiko|
抄録 Acute retinal necrosis syndrome (ARNS) is a herpetic infectious eye disease that presents clinicians with difficult decisions to make about the indication and timing of surgical intervention. Here I report 2 patients who underwent prophylactic and early vitrectomy with good visual outcomes. Case 1, a 72-year-old man, had a second recurrence of ARNS in the left eye in 2011 and underwent early vitrectomy in the acute inflammatory phase to remove previously formed vitreous opacity and vitreoretinal adhesions, in parallel with intravenous acyclovir and oral prednisolone administration. He had experienced ARNS in the right eye in 1983, in the left eye in 1986, and a recurrence in the left eye in 1999. Case 2, a 66-year-old woman, developed ARNS in the right eye. All of the circumferential retinal lesions became degenerative with intravenous acyclovir and prednisolone. She underwent a vitrectomy in the post-inflammatory phase, since epiretinal proliferation was noted through vitreous opacity with complete posterior vitreous detachment. These cases suggest that early vitrectomy in the acute inflammatory phase would be indicated for pre-existing vitreoretinal adhesions, while prophylactic vitrectomy in the post-inflammatory phase would be indicated for epiretinal proliferation.
キーワード acute retinal necrosis syndrome (ARNS) early vitrectomy epiretinal proliferation prophylactic vitrectomy herpetic retinitis
Amo Type Case Report
発行日 2012-12
出版物タイトル Acta Medica Okayama
66巻
6号
出版者 Okayama University Medical School
開始ページ 493
終了ページ 497
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23254584
Web of Sience KeyUT 000312966100009
JaLCDOI 10.18926/AMO/45273
フルテキストURL 65_2_135.pdf
著者 Matsuo, Toshihiko| Himei, Kengo| Ishii, Keita| Ichimura, Kouichi| Yanai, Hiroyuki| Nose, Soichiro| Mimura, Tetsushige|
抄録 An 18-year-old woman with a 2-year history of hypertension and headache was diagnosed with noradrenalin-secreting bilateral adrenal pheochromocytomas with paragangliomas in the background of von Hippel-Lindau disease with family histories and a missense mutation, 712C to T (Arg167Trp) in the VHL gene. She had optic disc hemangioma in the left eye which gradually enlarged and caused serous retinal detachment on the macula in one year. Low-dose external beam radiation (20 Gy) was administered to the left eye using a lens-sparing single lateral technique. She underwent craniotomy for cerebellar hemangioblastoma at the age of 22 years and total pancreatectomy for multiple neuroendocrine tumors at the age of 24 years. In the 6-year follow-up period after the radiotherapy, the optic disc hemangioma gradually reduced in size and its activity remained low, allowing good central vision to be maintained. External beam radiation is recommended as a treatment option for the initial therapy for optic disc hemangioma.
キーワード retinal (papillary, optic disc) hemangioma von Hippel-Lindau disease pheochromocytoma pancreatic neuroendocrine tumor external beam radiation (radiotherapy)
Amo Type Case Report
発行日 2011-04
出版物タイトル Acta Medica Okayama
65巻
2号
出版者 Okayama University Medical School
開始ページ 135
終了ページ 141
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 21519372
Web of Sience KeyUT 000289818800010
著者 原田 聡介| 武本 充広| 吉尾 浩太郎| 児島 克英| 片山 敬久| 勝井 邦彰| 黒田 昌宏| 松尾 俊彦| 金澤 右|
発行日 2010-12-01
出版物タイトル 岡山医学会雑誌
122巻
3号
資料タイプ 学術雑誌論文
著者 Kurauchi, Tomomi| Yokota, Kenji| Matsuo, Toshihiko| Fujinami, Yoshihito| Isogai, Emiko| Isogai, Hiroshi| Ohtsuki, Hiroshi| Oguma, Keiji|
発行日 2005-02-01
出版物タイトル FEMS Immunology and Medical Microbiology
43巻
2号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/32910
フルテキストURL 61_1_9.pdf
著者 Matsuo, Toshihiko| Matsuo, Chie| Matsuoka, Hiroaki| Kio, Keiko|
抄録 All children at the age of 1.5 and 3 years in Japan undergo physical, mental, and developmental checkups including dental, eye, and hearing examinations. The vision-screening program consists of 3 steps : questionnaires and home visual acuity testing as the first step (only for 3-year-old children), visual acuity testing by nurses and inspection by medical officers at regional Health Centers as the second step, and detailed examinations by ophthalmologists as the third step. This study aims to reveal the prevalence of strabismus and amblyopia as obtained from data in the vision-screening program. The final diagnoses made by ophthalmologists and sent back to the Health Centers in Okayama City were reviewed to elucidate the prevalence of strabismus, amblyopia, refractive errors, and other diseases in 1.5- and 3-year-old children in Okayama City in 5 years from 2000 to 2004. Of approximately 6,500-6,900 total children, 83.7-86.8% at 1.5 years old and 77.8-81.9% at 3 years old were brought to the Health Centers. The rates of strabismus were 0.01-0.12% at 1.5 years old and 0.20-0.34% at 3 years old, while the rates of amblyopia were 0% at 1.5 years old and 0.13-0.18% at 3 years old. The higher rates of strabismus at 3 years old were attributed mainly to the increase of exotropia and intermittent exotropia. In conclusions, the prevalence of strabismus was different between 1.5- and 3-year-old children. The vision-screening program in Japan functions to detect strabismus and amblyopia.
キーワード strabismus amblyopia esotropia exotropia preschool vision screening program
Amo Type Article
発行日 2007-02
出版物タイトル Acta Medica Okayama
61巻
1号
出版者 Okayama University Medical School
開始ページ 9
終了ページ 16
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 17332837
Web of Sience KeyUT 000244432400002
JaLCDOI 10.18926/AMO/32898
フルテキストURL fulltext.pdf
著者 Matsuo, Toshihiko| Masuda, Ikuya| Ota, Kosuke| Yamadori, Ichiro| Sunami, Reiko| Nose, Soichiro|
抄録 We describe herein 2 patients who developed Vogt-Koyanagi-Harada syndrome in the course of renal biopsy-proven immunoglobulin A (IgA) nephropathy. A 61-year-old man with an 11-year history of IgA nephropathy and a 16-year history of thyroiditis, and a 56-year-old man with a 5-year history of IgA nephropathy developed Vogt-Koyanagi-Harada syndrome. At the time of the eye disease presentation, IgA nephropathy was stable without corticosteroids in both patients. Vogt-Koyanagi-Harada syndrome was successfully treated with intravenous administration of prednisolone tapered from 200 mg daily. Vogt-Koyanagi-Harada syndrome is associated with IgA nephropathy, suggesting a similar autoimmune mechanism for both diseases.
キーワード immunoglobulin A (IgA) nephropathy Vogt-Koyanagi-Harada syndrome (disease)
Amo Type Case Report
発行日 2007-10
出版物タイトル Acta Medica Okayama
61巻
5号
出版者 Okayama University Medical School
開始ページ 305
終了ページ 309
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 17971847
Web of Sience KeyUT 000250431700008
JaLCDOI 10.18926/AMO/32877
フルテキストURL fulltext.pdf
著者 Matsuo, Toshihiko| Matsuo, Chie|
抄録 <p>We previously revealed the prevalence of strabismus and amblyopia in elementary school children between 6 and 12 years of age in Japan in the year 2003. Questionnaires asking the number of children with different types of strabismus and amblyopia were sent to all elementary schools in Okayama Prefecture in the year 2005, and the results in the year 2005 were compared with those obtained in the year 2003. The number of children covered by the return of questionnaires was 84,619 (74%) of 113,763 total pupils, including grades 1 to 6, in Okayama Prefecture in the year 2005. The total numbers of children with strabismus and amblyopia, including grades 1 to 6, were 844 (0.99%, 95% confidence interval: 0.94-1.06%) and 173 (0.20%, 95% confidence interval: 0.17-0.23%), respectively. The numbers of children with any type of exotropia and any type of esotropia were 524 (0.62%) and 187(0.22%), respectively. In the previous survey conducted in 2003, the number of children covered by the return of questionnaires was 86,531 (76%) of 113,254 total pupils. The total numbers of children with strabismus and amblyopia were 1,112 (1.28%, 95% confidence interval: 1.24-1.36%) and 125 (0.14%, 95% confidence interval: 0.12-0.17%), respectively. The numbers of children with any types of exotropia and esotropia were 602 (0.69) and 245 (0.28%), respectively. The prevalence of strabismus in this large population of Japanese elementary school children was significantly different between the years 2003 and 2005, while the prevalence of amblyopia was similar between the years.</p>
キーワード prevalence strabismus amblyopia elementary school vision screening program
Amo Type Original Article
発行日 2007-12
出版物タイトル Acta Medica Okayama
61巻
6号
出版者 Okayama University Medical School
開始ページ 329
終了ページ 334
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 18183077
Web of Sience KeyUT 000251943800003
JaLCDOI 10.18926/AMO/32833
フルテキストURL fulltext.pdf
著者 Fujiwara, Hirotake| Matsuo, Toshihiko| Sato, Masako| Yamane, Takashi| Kitada, Mizue| Hasebe, Satoshi| Ohtsuki, Hiroshi|
抄録 <p>The purpose of this study was to search for chromosomal susceptibility loci for comitant strabismus. Genomic DNA was isolated from 10mL blood taken from each member of 30 nuclear families in which 2 or more siblings are affected by either esotropia or exotropia. A genome-wide search was performed with amplification by polymerase chain reaction of 400 markers in microsatellite regions with approximately 10 cM resolution. For each locus, non-parametric affected sib-pair analysis and non-parametric linkage analysis for multiple pedigrees (Genehunter software, http://linkage.rockefeller.edu/soft/) were used to calculate multipoint lod scores and non-parametric linkage (NPL) scores, respectively. In sib-pair analysis, lod scores showed basically flat lines with several peaks of 0.25 on all chromosomes. In non-parametric linkage analysis for multiple pedigrees, NPL scores showed one peak as high as 1.34 on chromosomes 1, 2, 4, 7, 10, 15, and 16, while 2 such peaks were found on chromosomes 3, 9, 11, 12, 18, and 20. Non-parametric linkage analysis for multiple pedigrees of 30 families with comitant strabismus suggested a number of chromosomal susceptibility loci. Our ongoing study involving a larger number of families will refine the accuracy of statistical analysis to pinpoint susceptibility loci for comitant strabismus.&#60;/P&#62;</p>
キーワード chromosomal susceptibility locus esotropia exotropia genome-wide search strabismus
Amo Type Article
発行日 2003-06
出版物タイトル Acta Medica Okayama
57巻
3号
出版者 Okayama University Medical School
開始ページ 109
終了ページ 116
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 12908008
Web of Sience KeyUT 000183816500002
JaLCDOI 10.18926/AMO/32824
フルテキストURL fulltext.pdf
著者 Matsuo, Toshihiko|
抄録 <p>Photoelectric dyes absorb light and convert photon energy to electric potentials. To test whether these dyes could be used for retinal prostheses, a simple in vitro screening system was developed. Retinal neurons were cultured from the eyes of chick embryos at the 10-day embryonic stage, at which time no retinal photoreceptor cells have yet developed. Intracellular calcium elevation was observed with Fluo-4 in cultured retinal neurons before and after photoelectric dye was applied at varying concentrations to the culture medium. Five of 7 photoelectric dyes tested in this in vitro system induced intracellular calcium elevation in cultured chick retinal neurons. The intracellular calcium elevation generated by the 5 photoelectric dyes was blocked by extracellular calcium depletion in the case of all 5 dyes, and, except for one dye, by the presence of voltage-gated calcium channel blockers. The photoelectric dyes absorbed light under an inverted microscope and stimulated retinal neurons. This simple in vitro system allows the screening of photoelectric dyes which can be used for retinal prostheses.</p>
キーワード photoelectric dye (pigment) chick retinal neurons intracellular calcium retinal prostheses retinal implant
Amo Type Article
発行日 2003-10
出版物タイトル Acta Medica Okayama
57巻
5号
出版者 Okayama University Medical School
開始ページ 257
終了ページ 260
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 14679404
Web of Sience KeyUT 000186186000007
JaLCDOI 10.18926/AMO/32803
フルテキストURL fulltext.pdf
著者 yamane, Takashi| Matsuo, Toshihiko| Hasebe, Satoshi| Ohtsuki, Hiroshi|
抄録 <p>The purpose of this study was to elucidate the role of extracellular matrix components such as aggrecan, fibronectin, and laminin in the extraocular muscle of patients with strabismus. Resected tissues of the medial rectus muscle of 47 patients with intermittent exotropia obtained during recession-resection surgery were frozen under liquid nitrogen and pulverized by a Freezer/Mill to solubilize the tissue for enzyme immunoassay. The total amounts of aggrecan, fibronectin, and laminin in the resected tissue were correlated with clinical data of patients such as age, exodeviation, and refractive error. The amount of aggrecan decreased significantly with the advance of age (P &#60; 0.0001, Spearman rank correlation test), while the amount of laminin or fibronectin had no correlation with age. Patients with basic type intermittent exotropia showed larger, although not significantly, amounts of aggrecan than those with convergence insufficiency type (P = 0.0538, Mann-Whitney U-test). The amount of aggrecan may be related to motor aspects of intermittent exotropia.</p>
キーワード extraocular muscle aggrecan laminin fibronectin intermittent extropia
Amo Type Article
発行日 2003-08
出版物タイトル Acta Medica Okayama
57巻
4号
出版者 Okayama University Medical School
開始ページ 199
終了ページ 204
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 14627072
Web of Sience KeyUT 000184987100006