著者 中司 敦子| 和田 淳| 槇野 博史|
発行日 2012-08-01
出版物タイトル 岡山医学会雑誌
124巻
2号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/49041
フルテキストURL 66_6_449.pdf
著者 Hanayama, Yoshihisa| Uchida, Haruhito Adam| Nakamura, Yoshio| Makino, Hirofumi|
抄録 Angiotensin receptor blockers (ARBs) are the first-line antihypertensive agents. In clinical practice, it is often difficult to achieve the recommended blood pressure level by ARBs in their ordinal dosages alone. This study examined the practical efficacy of a combination therapy of ARB with thiazide diuretics for lowering morning home blood pressure (MHBP) in comparison to high-dose ARB therapy in patients with morning hypertension administered an ordinal dosage of ARB. This study was performed in a prospective, randomized, open-labeled and blind-endpoint fashion. Patients were considered to have morning hypertension when their self-measured systolic MHBPs were 135mmHg or higher, irrespective of their diastolic MHBP and office blood pressures (OBPs). Forty-eight outpatients with morning hypertension receiving the ordinal dosage of ARB were given either losartan/hydrochlorothiazide (n=26) or high-dose ARB (n=22) in place of their previously prescribed ARB. No change in any medication was permitted during this period. Decreases of both systolic and diastolic MHBP after 3 months of treatment were significantly greater in the losartan/hydrochlorothiazide group than in the high-dose ARB group (p<0.05, respectively). The ratio of adverse events was somewhat high (23.1% in the losartan/hydrochlorothiazide group, 9.1% in the high-dose ARB group, respectively). However, there were no significant differences in any particular adverse event between groups. This study suggested losartan/hydrochlorothiazide might be superior to high-dose ARB for reducing morning home blood pressure.
キーワード losartan hydrochlorothiazide morning blood pressure angiotensin II hyperuricemia
Amo Type Original Article
発行日 2012-12
出版物タイトル Acta Medica Okayama
66巻
6号
出版者 Okayama University Medical School
開始ページ 449
終了ページ 459
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23254579
Web of Science KeyUT 000312966100004
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/49736
著者 Takano, Mariko| Otsuka, Fumio| Matsumoto, Yoshinori| Inagaki, Kenichi| Takeda, Masaya| Nakamura, Eri| Tsukamoto, Naoko| Miyoshi, Tomoko| Sada, Ken-ei| Makino, Hirofumi|
発行日 2012-01-02
出版物タイトル Molecular and Cellular Endocrinology
348巻
1号
資料タイプ 学術雑誌論文
著者 Takiue, Keiichi| Sugiyama, Hitoshi| Inoue, Tatsuyuki| Morinaga, Hiroshi| Kikumoto, Yoko| Kitagawa, Masashi| Kitamura, Shinji| Maeshima, Yohei| Wang, Dahong| Masuoka, Noriyoshi| Ogino, Keiki| Makino, Hirofumi|
発行日 2012-05-25
出版物タイトル BMC Nephrology
13巻
14号
資料タイプ 学術雑誌論文
著者 Nakatsuka, Atsuko| Wada, Jun| Iseda, Izumi| Teshigawara, Sanae| Higashio, Kanji| Murakami, Kazutoshi| Kanzaki, Motoko| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Hida, Kazuyuki| Eguchi, Jun| Horiguchi, Chikage Sato| Ogawa, Daisuke| Matsuki, Yasushi| Hiramatsu, Ryuji| Yagita, Hideo| Kakuta, Shigeru| Iwakura, Yoichiro| Makino, Hirofumi|
発行日 2012-11
出版物タイトル Diabetes
61巻
11号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/50405
フルテキストURL 67_3_129.pdf
著者 Nakatsuka, Atsuko| Wada, Jun| Makino, Hirofumi|
抄録 In recent years, many researchers have emphasized the importance of metabolic syndrome based on its increasing prevalence and its adverse prognosis due to associated chronic vascular complications. Upstream of a cluster of metabolic and vascular disorders is the accumulation of visceral adipose tissue, which plays a central role in the pathophysiology. In the accumulation of adipose tissues, cell cycle regulation is tightly linked to cellular processes such as proliferation, hypertrophy and apoptosis. In addition, various cell cycle abnormalities have also been observed in other tissues, such as kidneys and the cardiovascular system, and they are critically involved in the progression of disease. Here, we discuss cell cycle abnormalities in metabolic syndrome in various tissues. Furthermore, we describe the role of nuclear receptors in cell growth and survival, and glucose and lipid metabolism in the whole body. Therapeutic strategies for modulating various cell cycles in metabolic disorders by targeting nuclear receptors may overcome obesity and its chronic vascular complications in the future.
キーワード nuclear receptor cell cycle metabolic syndrome diabetic nephropathy
Amo Type Review
発行日 2013-06
出版物タイトル Acta Medica Okayama
67巻
3号
出版者 Okayama University Medical School
開始ページ 129
終了ページ 134
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23804135
Web of Science KeyUT 000320747900001
著者 Inoue, Junko| Wada, Jun| Teshigawara, Sanae| Hida, Kazuyuki| Nakatsuka, Atsuko| Takatori, Yuji| Kojo, Shoichirou| Akagi, Shigeru| Nakao, Kazushi| Miyatake, Nobuyuki| McDonald, John F.| Makino, Hirofumi|
発行日 2012-12-03
出版物タイトル BMC Nephrology
13巻
資料タイプ 学術雑誌論文
著者 Nagase, Ryo| Kajitani, Nobuo| Shikata, Kenichi| Ogawa, Daisuke| Kodera, Ryo| Okada, Shinichi| Kido, Yuichi| Makino, Hirofumi|
発行日 2012-10
出版物タイトル Clinical and Experimental Nephrology
16巻
5号
資料タイプ 学術雑誌論文
著者 Kurose, Yuko| Wada, Jun| Kanzaki, Motoko| Teshigawara, Sanae| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Watanabe, Mayu| Higuchi, Chigusa| Eguchi, Jun| Miyatake, Nobuyuki| Makino, Hirofumi|
発行日 2013-01-22
出版物タイトル BMC Nephrology
14巻
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/52138
フルテキストURL 68_1_7.pdf
著者 Horimoto, Naoya| Kitamura, Shinji| Tsuji, Kenji| Makino, Hirofumi|
抄録 Immunosuppressive agents are generally administered to treat kidney diseases. However, it is unclear whether renal stem/progenitor cells are directly affected by the immunosuppressive agents. We used normal rat kidney cells, ureteric bud cells and rat kidney stem/progenitor cells in this study. Mizoribine (MZR), cyclophosphamide (CPA) and cyclosporine (CyA) were added to the culture media of these cells. We evaluated the effects of these immunosuppressive agents on cell proliferation using an electrical cell-substrate impedance sensing system (ECIS) and their effects on the process of renal regeneration using the ischemia-reperfusion (I/R) injury rat model. The ECIS data showed that proliferation of each of the 3 types of cells was significantly suppressed by MZR. MZR treatment enhanced renal tubular injury in ischemia-reperfusion (I/R) injured rats, and significantly decreased levels of M-phase cells and Nestin-positive cells. These results suggested that MZR inhibits the cell cycle of renal stem/progenitor cells;thus, physicians should take note that MZR might affect not only inflammation but also renal regeneration.
キーワード cell biology immunosuppression stem cells
Amo Type Original Article
発行日 2014-02
出版物タイトル Acta Medica Okayama
68巻
1号
出版者 Okayama University Medical School
開始ページ 7
終了ページ 15
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 24553483
Web of Science KeyUT 000331592800002
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/52247
JaLCDOI 10.18926/AMO/52143
フルテキストURL 68_1_43.pdf
著者 Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki|
抄録 The link between lifestyle modification and changes in both proteinuria and estimated glomerular filtration rates (eGFRs) was evaluated in Japanese subjects with proteinuria who were not taking medications. We used data from 51 men (35.8±10.0 years) and 74 women (38.0±11.0 years) with proteinuria at baseline and a 1-year follow up. eGFR was defined by a new equation developed specifically for Japanese subjects. Subjects were given advice for dietary and lifestyle improvement at the initial appointment. At the 1-year follow up, eGFR was increased in both sexes, but not at significant levels. (men:p=0.7709, women:p=0.2180). Proteinuria was also improved in many subjects. A decrease in proteinuria may be associated with improving eGFR in Japanese.
キーワード proteinuria estimated glomerular filtration rate (eGFR) lifestyle modification
Amo Type Short Communication
発行日 2014-02
出版物タイトル Acta Medica Okayama
68巻
1号
出版者 Okayama University Medical School
開始ページ 43
終了ページ 46
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 24553488
Web of Science KeyUT 000331592800007
タイトル(別表記) Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophages
フルテキストURL 126_1.pdf
著者 宮本 聡| 四方 賢一| 宮坂 京子| 岡田 震一| 佐々木 基史| 小寺 亮| 廣田 大昌| 梶谷 展生| 高塚 哲全| 片岡 仁美| 西下 伸吾| 堀口 千景| 船越 顕博| 西森 久和| 内田 治仁| 小川 大輔| 槇野 博史|
キーワード cholecystokinin 糖尿病性腎症 抗炎症作用 腎保護効果
出版物タイトル 岡山医学会雑誌
発行日 2014-04-01
126巻
1号
開始ページ 1
終了ページ 6
ISSN 0030-1558
関連URL http://www.okayama-u.ac.jp/user/oma/
言語 Japanese
著作権者 Copyright (c) 2014 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.126.1
著者 Kitagawa, Masashi| Sugiyama, Hitoshi| Morinaga, Hiroshi| Inoue, Tatsuyuki| Takiue, Keiichi| Ogawa, Ayu| Yamanari, Toshio| Kikumoto, Yoko| Uchida, Haruhito Adam| Kitamura, Shinji| Maeshima, Yohei| Nakamura, Kazufumi| Ito, Hiroshi| Makino, Hirofumi|
発行日 2013-02-19
出版物タイトル PLoS ONE
8巻
2号
資料タイプ 学術雑誌論文
著者 Kagawa, Hidetoshi| Hiromasa, Tsutomu| Hara, Takayuki| Takaki, Ayako| Yamanaka, Ryutaro| Sada, Ken-ei| Makino, Hirofumi|
発行日 2012-10
出版物タイトル Clinical and Experimental Nephrology
16巻
5号
資料タイプ 学術雑誌論文
著者 Sugiyama, Koichi| Sada, Ken-ei| Kurosawa, Michiko| Wada, Jun| Makino, Hirofumi|
発行日 2013-02
出版物タイトル Clinical and Experimental Nephrology
17巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/52788
フルテキストURL 68_4_219.pdf
著者 Hinamoto, Norikazu| Maeshima, Yohei| Saito, Daisuke| Yamasaki, Hiroko| Tanabe, Katsuyuki| Nasu, Tatsuyo| Watatani, Hiroyuki| Ujike, Haruyo| Kinomura, Masaru| Sugiyama, Hitoshi| Sonoda, Hikaru| Kanomata, Naoki| Sato, Yasufumi| Makino, Hirofumi|
抄録 Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r=0.48, p=0.001) or cortex (r=0.64, p<0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r=0.34, p=0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r=0.44, p=0.01) or medulla (r=0.63, p=0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2.
キーワード chronic kidney disease inflammation Vasohibin-1 VEGF-A VEGFR-2
Amo Type Original Article
発行日 2014-08
出版物タイトル Acta Medica Okayama
68巻
4号
出版者 Okayama University Medical School
開始ページ 219
終了ページ 233
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 25145408
Web of Science KeyUT 000340687500004
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/52824
JaLCDOI 10.18926/AMO/52789
フルテキストURL 68_4_235.pdf
著者 Ono, Tetsuichiro| Shikata, Kenichi| Obika, Mikako| Miyatake, Nobuyuki| Kodera, Ryo| Hirota, Daisyo| Wada, Jun| Kataoka, Hitomi| Ogawa, Daisuke| Makino, Hirofumi|
抄録 The aim of this study was to clarify the factors associated with the remission and/or regression of microalbuminuria in Japanese patients with type 2 diabetes mellitus. We retrospectively analyzed the data of 130 patients with type 2 diabetes mellitus with microalbuminuria for 2-6 years (3.39±1.31 years). Remission was defined as improving from microalbuminuria to normoalbuminuria using the albumin/creatinine ratio (ACR), and regression of microalbuminuria was defined as a decrease in ACR of 50% or more from baseline. Progression of microalbuminuria was defined as progressing from microalbuminuria to overt proteinuria during the follow-up period. Among 130 patients with type 2 diabetes mellitus with microalbuminuria, 57 and 13 patients were defined as having remission and regression, respectively, while 26 patients progressed to overt proteinuria. Sex (female), higher HDL cholesterol and lower HbA1c were determinant factors associated with remission/regression of microalbuminuria by logistic regression analysis. Lower systolic blood pressure (SBP) was also correlated with remission/regression, but not at a significant level. These results suggest that proper control of blood glucose, BP and lipid profiles may be associated with remission and/or regression of type 2 diabetes mellitus with microalbuminuria in clinical practice.
キーワード microalbuminuria type 2 diabetes mellitus remission regression
Amo Type Original Article
発行日 2014-08
出版物タイトル Acta Medica Okayama
68巻
4号
出版者 Okayama University Medical School
開始ページ 235
終了ページ 241
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 25145409
Web of Science KeyUT 000340687500005
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/52828
著者 Terasaka, Tomohiro| Otsuka, Fumio| Tsukamoto, Naoko| Nakamura, Eri| Inagaki, Kenichi| Toma, Kishio| Ogura-Ochi, Kanako| Glidewell-Kenney, Christine| Lawson, Mark A.| Makino, Hirofumi|
発行日 2013-12-05
出版物タイトル Molecular and Cellular Endocrinology
381巻
1-2号
資料タイプ 学術雑誌論文
著者 Nakayama, Kazunori| Nakao, Kazushi| Takatori, Yuji| Inoue, Junko| Kojo, Shoichirou| Akagi, Shigeru| Fukushima, Masaki| Wada, Jun| Makino, Hirofumi|
発行日 2013-12-18
出版物タイトル International Journal of Nephrology and Renovascular Disease
7巻
資料タイプ 学術雑誌論文
著者 Inoue, Kentaro| Wada, Jun| Eguchi, Jun| Nakatsuka, Atsuko| Teshigawara, Sanae| Murakami, Kazutoshi| Ogawa, Daisuke| Terami, Takahiro| Katayama, Akihiro| Tone, Atsuhito| Iseda, Izumi| Hida, Kazuyuki| Yamada, Masao| Ogawa, Tomohisa| Makino, Hirofumi|
発行日 2013-10-15
出版物タイトル PLoS ONE
8巻
10号
資料タイプ 学術雑誌論文