著者 Iwanaga, Suketaka| Sakano, Noriko| Taketa, Kazuhisa| Takahashi, Noriko| Wang, Da-Hong| Takahashi, Hidekazu| Kubo, Masayuki| Miyatake, Nobuyuki| Ogino, Keiki|
発行日 2013-02-01
出版物タイトル Obesity Research & Clinical Practice
資料タイプ 学術雑誌論文
著者 Inoue, Kiyomi| Sakano, Noriko| Ogino, Keiki| Sato, Yoshie| Wang, Da-Hong| Kubo, Masayuki| Takahashi, Hidekazu| Kanbara, Sakiko| Miyatake, Nobuyuki|
発行日 2013-03-01
出版物タイトル Journal of Clinical Biochemistry and Nutrition
52巻
2号
資料タイプ 学術雑誌論文
著者 Nakagawa, Shinya| Kataoka, Takahiro| Mizuguchi, Yuko| Yoshimoto, Masaaki| Sakoda, Akihiro| Nomura, Takaharu| Wang, Da-Hong| Kawabe, Atsushi| Taguchi, Takehito| Yamaoka, Kiyonori|
発行日 2008-07
出版物タイトル Journal of Clinical Biochemistry and Nutrition
43巻
1号
資料タイプ 学術雑誌論文
著者 Yamaoka, Kiyonori| Kataoka, Takahiro| Nomura, Takaharu| Taguchi, Takehito| Wang, Da-Hong| Mori, Shuji| Hanamoto, Katsumi| Kira, Shohei|
発行日 2004-05-07
出版物タイトル Journal of Radiation Research
45巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/48561
フルテキストURL 66_3_221.pdf
著者 Takahata, Yoko| Wang, Da-Hong| Anai, Takanobu| Ogino, Keiki|
抄録 This study aimed to elucidate the relationship of prenatal and/or postnatal factors, including acquired factors, with the calcaneus stiffness index as measured by quantitative ultrasound (QUS-SI) in adolescents. We recruited 1,143 adolescents with a mean age of 14.8±1.8 years (501 boys and 642 girls). The subjectsʼ calcaneus QUS-SI was measured using an ultrasound bone densitometer. We also measured the subjectsʼ height, weight, and grip strength. Data on prenatal and postnatal factors were obtained from maternal and child health handbooks. A self-reporting questionnaire was used to obtain information on subjectsʼ secondary sexual characteristics and lifestyle factors. We found that maternal weight gain during pregnancy was independently associated with calcaneus QUS-SI in girls, and that grip strength was also significantly associated with calcaneus QUS-SI in both sexes. The present findings suggest that excessive restriction of maternal weight gain would have a negative effect on the calcaneus QUS-SI of girls, and that exercise and strength-building activities are likely to result in a higher calcaneus QUS-SI in both sexes of adolescents.
キーワード adolescents calcaneus QUS-SI prenatal and/or postnatal status stiffness index ultrasound bone densitometer
Amo Type Original Article
発行日 2012-06
出版物タイトル Acta Medica Okayama
66巻
3号
出版者 Okayama University Medical School
開始ページ 221
終了ページ 229
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
Submission Path amo/vol66/iss3/5
PubMed ID 22729102
Web of Sience KeyUT 000305669700005
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/48455
JaLCDOI 10.18926/AMO/43829
フルテキストURL 65_1_41.pdf
著者 Tokumori, Kimihiko| Wang, Da-Hong| Takigawa, Tomoko| Takaki, Jiro| Ogino, Keiki|
抄録 This study aimed to determine whether there was any association between the regional climate and the proportion of people with joint pain. Regional climate data between 1971 and 2000 were obtained from the Japan Meteorological Agency. The variables used in the cluster analysis included sunlight hours, amount of precipitation, number of days with precipitation, and temperature. The regional proportion of people with joint pain was obtained from the National Survey for Health in 2001. After performing a cluster analysis, one-way ANOVA and Welch's test were used to determine whether the climate characteristics of the clusters were significantly different. Within each cluster, stepwise multiple linear regression analyses were performed. We found that sunlight hours showed a direct, negative association with the proportion of people with joint pain (adjusted R2=0.532, p=0.016) in cluster 1, which was characterized as the region with the fewest total hours of sunlight, less precipitation, a modest number of rainy days, and low temperature. In the other clusters, the regional female population rate (cluster 2) and the senior population rate (cluster 3, 4) were the primary predictors. We concluded that the degree of exposure to sunlight may play a crucial role in prevention of joint pain. This finding should encourage people to set aside some time for staying outdoors in their daily lives.
キーワード climate joint pain sunlight hours cluster analysis
Amo Type Original Article
発行日 2011-02
出版物タイトル Acta Medica Okayama
65巻
1号
出版者 Okayama University Medical School
開始ページ 41
終了ページ 48
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン publisher
査読 有り
Submission Path amo/vol65/iss1/6
PubMed ID 21339795
Web of Sience KeyUT 000287620500006
JaLCDOI 10.18926/AMO/32911
フルテキストURL fulltext.pdf
著者 Takemoto, Kei| Ogino, Keiki| Wang, Da-Hong| Takigawa, Tomoko| Kurosawa, Carmen M.| Kambayashi, Yasuhiro| Hibino, Yuri| Hitomi, Yoshiaki| Ichimura, Hiroshi|
抄録 <p>It is well known that eosinophils are involved in tyrosine nitration. In this study, we evaluated tyrosine nitration by rat eosinophils isolated from peritoneal fl uid and constituent eosinophils in the stomach. Rat peritoneal eosinophils activated with 1 &#956;M phorbol myristate acetate (PMA) and 50 &#956;M NO2 &#65437; showed immunostaining for nitrotyrosine only in smaller cells, despite the fact that eosinophils are capable of producing superoxide (O2·&#65437;). Free tyrosine nitrating capacity after incubation with PMA and NO2 &#65437; was 4-fold higher in eosinophils than in neutrophils. Catalase and &#65400;- and &#65402; -tocopherol inhibited free tyrosine nitration by reactive nitrogen species from eosinophils but not that by peroxynitrite. Superoxide dismutase augmented free tyrosine nitration by activated eosinophils and peroxynitrite. The concentration of nitric oxide released from eosinophils was relatively low (0.32 &#956;M/106 cells/h) and did not contribute to the formation of nitrotyrosine. On the other hand, most constituent eosinophils constituent in the rat stomach stimulated by PMA and NO2 &#65437; showed tyrosine nitration capacity. These results suggest that intact cells other than apoptotic-like eosinophils eluted in the intraperitoneal cavity could not generate reactive species responsible for nitration by a peroxidase-dependent mechanism. In contrast, normal eosinophils in the stomach were capable of nitration, suggesting that the characteristics of eosinophils in gastric mucosa are diff erent from those eluted in the peritoneal cavity.</p>
キーワード eosinophil peroxidase reactive nitrogen species nitrotyrosine
Amo Type Article
発行日 2007-02
出版物タイトル Acta Medica Okayama
61巻
1号
出版者 Okayama University Medical School
開始ページ 17
終了ページ 30
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol61/iss1/3
PubMed ID 17332838
Web of Sience KeyUT 000244432400003
JaLCDOI 10.18926/AMO/32887
フルテキストURL fulltext.pdf
著者 Yajima, Yuki| Tsutsui, Takako| Nakajima, Kazuo| Li, Hui-Ying| Takigawa, Tomoko| Wang, Da-Hong| Ogino, Keiki|
抄録 <p>The purpose of the study was to investigate the over-time effects of physical, psychological and social resources on the incidence of depression in family caregivers of the disabled elderly. Data were collected twice at a one-year interval from 1,141 primary caregivers of a disabled older person in an urban area of Japan using a self-reported questionnaire survey. The questionnaire included physical health as an indicator of physical resources, caregiving satisfaction and intention to care as indicators of psychological resources, and instrumental and emotional support network and formal home care service utilization as indicators of social resources. The mental health outcome measure was the General Health Questionnaire 12-item version (GHQ-12). Complete data on 235 non-depressed female caregivers were separated into 3 groups according to the relationship type (wife, daughter and daughter-in-law) and analyzed separately. Multivariate logistic regression models controlling for duration of caregiving, care-recipient's gender, ADL dependency and behavioral problems demonstrated that significant predictors of depression were caregiving satisfaction and intention to care in wives, caregiving satisfaction in daughters, and physical health and emotional support network in daughters-in-law. Noteworthy, intention to care increased the risk of depression in wives, while decreasing the risk of depression in daughters-in-law. The findings indicate that the effects of caregivers' resources on mental health may differ by relationship type.</p>
キーワード caregivers kin relationships caregiving resources depression
Amo Type Original Article
発行日 2007-04
出版物タイトル Acta Medica Okayama
61巻
2号
出版者 Okayama University Medical School
開始ページ 71
終了ページ 80
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol61/iss2/4
PubMed ID 17471307
Web of Sience KeyUT 000245875600004
JaLCDOI 10.18926/AMO/32871
フルテキストURL fulltext.pdf
著者 Ogino, Keiki| Wang, Da-Hong|
抄録 Oxidative/nitrosative stress is responsible for a variety of degenerative processes in some human diseases. Measurement of oxidatively/nitrosatively modified DNA, proteins, lipids, and sugars in biological samples has been expected to detect appropriate biomarkers for diseases in which reactive oxygen/nitrogen species are involved. Recently, the application of these biomarkers to epidemiological studies has resulted in a new discipline, molecular epidemiology, which provides the opportunity for better understanding of their causal relation with disease outcomes in a population level. In this brief review, we cover some specific biomarkers of oxidative/nitrosative stress with regard to the commonly used analytical methods for these biomarkers, their integration with epidemiology, and their application in antioxidant intervention trials, with an emphasis on those applicable to human studies and their potentialities for disease prevention.
キーワード biomarker oxidative/nitrosative stress molecular epidemiology disease prevention
Amo Type Review
発行日 2007-08
出版物タイトル Acta Medica Okayama
61巻
4号
出版者 Okayama University Medical School
開始ページ 181
終了ページ 189
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol61/iss4/1
PubMed ID 17726507
Web of Sience KeyUT 000248957100001
JaLCDOI 10.18926/AMO/32805
フルテキストURL fulltext.pdf
著者 Matsuka, Yoko| Wang, Da-Hong| Suganuma, Narufumi| Imai, Kaori| Ikeda, Satoru| Taketa, Kazuhisa| Kira, Shohei|
抄録 <p>We studied the association of gamma-glutamyltransferase (GGT) and other serum markers of liver injury with daily alcohol consumption in a healthy population of 1,043 Japanese males. A positive correlation between daily alcohol consumption and biochemical markers, such as log GGT (r = 0.432), log AST (r = 0.244) or log LAP (r = 0.246), was seen in all drinkers. However, there was a negative correlation, such as log GGT (r = -0.434), log AST (r = -0.424) or log LAP (r = -0.430), in heavy drinkers who consumed more than 70 g ethanol a day. On the other hand, a positive correlation, such as log GGT (r = 0.426), log AST (r = 0.247) or log LAP (r = 0.216) was found in moderate drinkers who consumed less than 70 g ethanol a day. Interestingly, there was a tendency toward negative association between alcohol consumption and the Tokyo University ALDH2 Phenotype Screening Test (TAST) score in the heavy drinkers, and there was a tendency toward positive association between GGT and TAST score in this group. Our results suggest that there are 2 groups of drinkers, those with elevated GGT (good responders) and those with normal GGT (poor responders) despite heavy drinking.</p>
キーワード gamma-glutamyltransferase(GGT) daily alcohol consumption good responder and poor responder
Amo Type Article
発行日 2003-08
出版物タイトル Acta Medica Okayama
57巻
4号
出版者 Okayama University Medical School
開始ページ 171
終了ページ 178
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol57/iss4/2
PubMed ID 14627068
Web of Sience KeyUT 000184987100002
JaLCDOI 10.18926/AMO/31951
フルテキストURL fulltext.pdf
著者 Miyatake, Nobuyuki| Kogashiwa, Michiko| Wang, Da-Hong| Kira, Shohei| Yamasato, Teruhiro| Fujii, Masafumi|
抄録 <p>We evaluated the visceral adipose tissue accumulation in university students in Okayama prefecture, Japan. Fifty-eight Japanese university students (10 men and 48 women, age 18.4 +/- 0.6 years)were enrolled in this study. Fat distribution was evaluated by visceral fat (V) and subcutaneous fat (S) areas measured with computed tomography (CT) scanning at umbilical levels. Anthropometric parameters,i.e., height, weight, waist circumference, hip circumference, and body fat percentage; blood examination; and blood pressure (BP) were also measured. In 58 subjects, the V area was 23.4 +/- 21.0 cm(2) and the S area was 122.5 +/- 57.9 cm(2). V areas were significantly correlated with hepatic enzymes, uric acid, triglyceride, and BP in men, while they were weakly correlated with hepatic enzymes, triglyceride, and high density lipoprotein (HDL) cholesterol in women. Correlation coefficients between V areas and clinical parameters were comparatively higher than those between other body composition parameters,i.e., S areas, weight, body mass index (BMI), body fat percentage, and clinical parameters. The present study suggests that visceral adipose tissue accumulation is important for hepatic enzymes, uric acid, triglyceride, and BP in university students.</p>
キーワード visceral adipose tissue Japanese university students lifestyle-related disease
Amo Type Article
発行日 2005-08
出版物タイトル Acta Medica Okayama
59巻
4号
出版者 Okayama University Medical School
開始ページ 129
終了ページ 134
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol59/iss4/3
PubMed ID 16155638
Web of Sience KeyUT 000231478000003
JaLCDOI 10.18926/AMO/31694
フルテキストURL fulltext.pdf
著者 Takigawa, Tomoko| Kishimoto, Takumi| Nabe, Makoto| Nishide, Tadashi| Wang, Da-Hong| Seki, Akihiko| Uchida, Genkei| Kira, Shohei|
抄録 <p>This study involved the examination of 1,006 chest x-ray films of workers from the industries devoted to shipyard welding, stone grinding, and refractory crushing in southern Okayama prefecture. Of the reviewed films, analysis was focused on subjects with a profusion rate of 0/1 as well as pneumoconiotic subjects (exhibiting profusion rates of 1/0 or greater) in order to discover cases in the beginning stages. One-hundred-and-seventy-four films illustrated a profusion rate of 0/1 or greater, and the proportion of this profusion rate was revealed to be highest in shipyard welders. Even some workers under 40 years of age were found to have already developed pneumoconiosis. Of these 1,006 subjects, 30 volunteers permitted us to measure their personal dust exposure concentrations. The measured concentration of the shipyard welders' dust exposure (respirable dust; 3.3 86.3 mg/m3, total dust; 7.5-117.0 mg/m3) was higher than those of the other 2 industries. Statistical differences among the industries were observed in the respirable dust concentrations. A statistically significant positive correlation was demonstrated between the working duration in dusty environments and the rate of profusion. The present findings suggest the need for taking adequate measures in Okayama in order to prevent workers from developing, or to help retard the progression of, pneumoconiosis.</p>
キーワード pneumoconiosis profusion dust exposure shipyard welder Japan
Amo Type Article
発行日 2002-12
出版物タイトル Acta Medica Okayama
56巻
6号
出版者 Okayama University Medical School
開始ページ 303
終了ページ 308
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol56/iss6/5
PubMed ID 12685859
Web of Sience KeyUT 000179959000005
JaLCDOI 10.18926/AMO/31637
フルテキストURL fulltext.pdf
著者 Masatomi, Chie| Imai, Kaori| Wang, Da-Hong| Ikeda, Satoru| Taketa, Kazuhisa| Takata, Shinji| Kira, Shohei|
抄録 <p>The relationship between past and present lifestyle and urinary excretion of type I collagen cross-linked N-telopeptides (NTx) was studied in 61 Japanese females aged 34-59, with a view toward using NTx excretion rates as a predictor of future osteoporosis. Bone mineral density (BMD) of the lumbar spine, the speed of sound (SOS) and broadband ultrasound attenuation (BUA) of the os calcis, urinary NTx, serum osteocalcin (BGP) and bone-specific alkaline phosphatase (BAP) were measured. Stiffness index (stiffness) was calculated from SOS and BUA. The subjects were asked whether they took regular exercise in their childhood and teen years (in elementary, junior-high, senior-high school and college), the past (20-40 years of age) and present adulthood. Regular calcium intake, smoking habits, alcohol and other beverage consumption and milk consumption were also covered in the questionnaire. The mean NTx values of premenopausal and postmenopausal group were 22.2 and 56.0 nM bone collagen equivalents (BCE)/mM urinary creatinine (Cr), respectively. The group which did not exercise regularly between the ages of 20 and 40 had a higher mean NTx value (40.9 nMBCE/mMCr) than the group which did exercise regularly (22.7 nMBCE/mMCr). In multiple regression analyses, age, stiffness and exercise in past adulthood could explain 43.5% of the NTx variance. For prevention of bone metabolic increases around menopause, habitual exercise in early adulthood seems to be effective.</p>
キーワード N-telopeptides bone turnover osteoporosis menopause lifestyle
Amo Type Article
発行日 1999-06
出版物タイトル Acta Medica Okayama
53巻
3号
出版者 Okayama University Medical School
開始ページ 133
終了ページ 140
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol53/iss3/6
Web of Sience KeyUT 000081201100006
JaLCDOI 10.18926/AMO/31326
フルテキストURL fulltext.pdf
著者 Suganuma, Narufumi| Ikeda, Satoru| Taketa, Kazuhisa| Wang, Da-hong| Yamamoto, Hideki| Phornphukutkul, Kannika| Peerakome, Supatra| Sitvacharanum, Kriegsak| Jittiwutlkarn, Jaroon|
抄録 <p>An exposure to GB virus C/hepatitis G virus (GBV-C/HGV) was studied among populations at risk for blood and sexual exposure to analyze risk factor of the transmission of the virus. Blood samples were drawn from 98 intravenous drug users (IVDU), 100 female high-class commercial sex workers (CSW) and 50 male outpatients (MOP) at a sexually transmitted diseases (STD) clinic in Chiang Mai, Thailand. These blood samples were analyzed for GBV-C/HGV RNA; antibodies against second envelope protein of GBV-C/HGV (anti-E2); anti-hepatitis C virus antibody (HCV-Ab); hepatitis B core antibody (HBcAb); and antibodies against human immunodeficiency virus (HIV-Ab). Prevalences of GBV-C/HGV RNA, anti-E2, HCV-Ab, HBcAb and HIV-Ab were 27.6%, 16.3%, 84.7%, 76.5% and 45.0% in IVDU; 0%, 21.5%, 2.0%, 72.0% and 11.0% in CSW; 6.0%, 13.6%, 0%, 64.0% and 14.0% in MOP. While the prevalence of GBV-C/HGV RNA was higher in IVDU than in CSW and MOP, comparable prevalences of anti-E2 among the three populations were found. Intravenous drug injection showed association with GBV-C/HGV RNA, while history of STD associated with anti-E2. In conclusion, intravenous drug injection and STD were found to be risk factors for the previous exposure to GBV-C/HGV, but STD did not increase the risk of the GBV-C/HGV viraemia.</p>
キーワード GB virus C/hepatitis G virus anti-E2 anti-body sexualty transmitted disease human immunodeficiency virus hepatitis C virus
Amo Type Article
発行日 1998-06
出版物タイトル Acta Medica Okayama
52巻
3号
出版者 Okayama University Medical School
開始ページ 161
終了ページ 167
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol52/iss3/7
PubMed ID 9661744
Web of Sience KeyUT 000074528500007
JaLCDOI 10.18926/AMO/30970
フルテキストURL fulltext.pdf
著者 Kurosawa, Carmen Miwa| Ito, Takehiko| Takaki, Jiro| Wang, Bing-Ling| Wang, Da-Hong| Takigawa, Tomoko| Ogino, Keiki|
抄録 <p>In the present study, we examined the dynamic of school-health-based parasite control and the related socio-economic influences. This is an ecological study based on data from 46 prefectures in Japan. The exponential decay of Ascaris lumbricoides prevalence was calculated by iterative least-squares method. Pearson&#700;s correlation and multiple linear regression model analysis were performed to assess the associations between the prevalence of Ascaris lumbricoides in Japanese school children and socio-economic variables such as the prefecture income per capita, the percentage of primary industry, the population density per 1 km2, the diffusion rate of population under water supply, and the percentage of upper secondary school enrollment. The results indicated that the parasite carrier rate was higher in younger students. The half-life of Ascaris lumbricoides prevalence was approximately 3 years with significant variation among prefectures. Multiple regression analyses showed that the decrease of infection in elementary and lower secondary school children had a significant positive association with primary industry and a significant negative association with prefecture income per capita. The school-health-based parasite intervention differs by prefecture and has changed over time according to the respective prefectural stage of economic development.</p>
キーワード Ascaris lumbricoides parasite control school-health-based approach economic growth
Amo Type Original Article
発行日 2008-10
出版物タイトル Acta Medica Okayama
62巻
5号
出版者 Okayama University Medical School
開始ページ 303
終了ページ 312
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol62/iss5/4
PubMed ID 18985090
Web of Sience KeyUT 000260391300004
JaLCDOI 10.18926/AMO/30957
フルテキストURL fulltext.pdf
著者 Takemura, Yoko| Kishimoto, Takumi| Takigawa, Tomoko| Kojima, Shinji| Wanga, Bing-Ling| Sakano, Noriko| Wang, Da-Hong| Takaki, Jiro| Nishide, Tadashi| Ishikawa, Kou| Ogino, Keiki|
抄録 <p>To decrease the incidence of pneumoconiosis, we examined dust protective mask performance and its relation to pulmonary function as well as the effects of worker education on the proper wearing of masks. One hundred and seventy-eight workers from 15 factories subject to dust exposure participated in this study. All participants were interviewed to obtain relevant personal information and underwent both a mask leakage and a pulmonary function test. The mask leakage was expressed as a percentage, with under 10% leakage indicating that the dust protective mask worked efficiently. In addition, 23 workers from 2 factories were educated on how to wear masks properly. The average mask leakage was 24.3%, and 58% of workers wore ineffective masks. Though pulmonary function was almost normal, the percent vital capacity (%VC) tended to be lower depending on the mask leakage. Mask education, which was very easy and took only a short time, dramatically decreased average mask leakage from 32.1% to 10.5% (p0.001). Educating workers to wear masks properly might prevent the worsening of pulmonary function in response to dust exposure. Appropriate mask fitness by education could be useful in preventing the development of pneumoconiosis.</p>
キーワード pulmonary function education on proper wearing masks pneumoconiosis mask leakage occupational exposure
Amo Type Original Article
発行日 2008-04
出版物タイトル Acta Medica Okayama
62巻
2号
出版者 Okayama University Medical School
開始ページ 75
終了ページ 82
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol62/iss2/2
PubMed ID 18464883
Web of Sience KeyUT 000255297600003
JaLCDOI 10.18926/AMO/30951
フルテキストURL fulltext.pdf
著者 Ogata, Masana| Wang, Da-Hong| Ogino, Keiki|
抄録 <p>The molecular defects in the catalase gene, levels of m-RNA and properties of the residual catalase studied by scientists are reviewed in human (Japanese, Swiss and Hungarian) and non-human (mouse and beagle dog) acatalasemia with reference to the bioinformatics. Japanese acatalasemia-I, the G to A transition at the fifth position of intron 4 of the catalase gene, limited the correct splicing of the mRNA and synthesized trace catalase with normal properties. Hungarian acatalasemia type C showed a splicing mutation. In the Japanese acatalasemia II and the type A and B of Hungarian acatalasemia, the deletion or insertion of nucleotides was observed in the coding regions, and the frame shift altered downstream amino acid sequences and formed truncated proteins. In the Hungarian acatalasemia D, the substitution of a nucleotide in the exon was found. In mouse and beagle dog acatalasemia, the substitution of nucleotides in the coding regions was also observed. Studies of residual catalase in Swiss, mouse and beagle dog acatalasemia showed that aberrant catalase protein degrades more quickly than normal catalase in cells. The experimental research in genetic toxicology concerning the effect of oxidative stressors (nitrogen monoxide, nitrogen dioxide and so on) on Japanese acatalasemic blood and acatalasemic mice is described. The clinical features of Japanese and Hungarian acatalasemic subjects are also described.</p>
キーワード acatalasemia catalase novel mutation bioinformatics genetic toxicology
Amo Type Review
発行日 2008-12
出版物タイトル Acta Medica Okayama
62巻
6号
出版者 Okayama University Medical School
開始ページ 345
終了ページ 361
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol62/iss6/1
Web of Sience KeyUT 000262025000001
JaLCDOI 10.18926/AMO/30736
フルテキストURL fulltext.pdf
著者 Inukai, Yoshihide| Takahashi, Kayo| Wang, Da-Hong| Kira, Shohei|
抄録 <p>This study assessed total and segmental distribution of fat mass (FM) in athletes with spinal cord injury (SCI) and examined the relationships between segmental distribution of fat mass and age, injury level, athletic history, and training load in order to provide useful information for improvements in their physical strength and training. Twenty-five male athletes with SCI participated in the study. The whole bone composition was measured by a dual-energy X-ray absorptiometry (DXA) method for the calculation of bone minerals, FM, and fat-free mass. The percent fat of the trunk, arms, and legs was also calculated. The percent fat in the legs was highest in comparison with that in the trunk and arms (p &#60; 0.001), and the percent fat in the trunk was higher than that in the arms (p &#60; 0.001). The body fat (p &#60; 0.01), waist circumference (p &#60; 0.01), and waist-to-hip ratio (p &#60; 0.0001) were higher in the group aged 40 or older in comparison with that aged 39 or younger. Path analysis revealed that training load was a factor decreasing the percent fat on the arms and trunk (p &#60; 0.01), and athletic history was a factor reducing the percent fat on the arms (p &#60; 0.05). Our study suggests that exercise is effective in reducing the waist circumference, waist-to-hip ratio, and percent body fat of SCI individuals, and that such effects can help to enhance athletic performance and likely to protect against development of metabolic syndromes resulting from a sedentary lifestyle.</p>
キーワード body composition percentage of fat DXA spinal cord-injured athletes path analysis
Amo Type Article
発行日 2006-04
出版物タイトル Acta Medica Okayama
60巻
2号
出版者 Okayama University Medical School
開始ページ 99
終了ページ 106
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol60/iss2/5
PubMed ID 16680186
Web of Sience KeyUT 000237001900005
著者 川北 祝史| 宮武 伸行| 瀧川 智子| 汪 達紘| 荻野 景規| 沼田 健之|
発行日 2007-09-03
出版物タイトル 岡山医学会雑誌
119巻
2号
資料タイプ 学術雑誌論文
著者 汪 達紘|
発行日 1996-09-30
出版物タイトル
資料タイプ 学位論文