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ID 48264
JaLCDOI
フルテキストURL
著者
Watanabe, Makiko Department of Medical Technology, Graduate School of Health Sciences, Okayama University
Ueno, Hiroshi Department of Medical Technology, Graduate School of Health Sciences, Okayama University
Suemitsu, Shunsuke Koyodai Hospital
Yokobayashi, Eriko Department of Psychiatry, Kawasaki Medical University
Matsumoto, Yosuke Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Usui, Shinichi Department of Medical Technology, Graduate School of Health Sciences, Okayama University
Sujiura, Hiroko Department of Medical Technology, Graduate School of Health Sciences, Okayama University
Okamoto, Motoi Department of Medical Technology, Graduate School of Health Sciences, Okayama University
抄録
Recent studies have demonstrated the important role of immune molecules in the development of neuronal circuitry and synaptic plasticity. We have detected the presence of FcγRllB protein in parvalbumin- containing inhibitory interneurons (PV neurons). In the present study, we examined the appearance of PV neurons in the barrel cortex and the effect of sensory deprivation in FcγRllB-deficient mice (FcγRllB-/-) and wild-type mice. There was no substantial difference in the appearance of PV neurons in the developing barrel cortex between FcγRllB-/- and wild-type mice. Sensory deprivation from immediately after birth (P0) or P7 to P12-P14 induced an increase in PV neurons. In contrast, sensory deprivation from P7 or P14 to P28, but not from P21 to P28, decreased PV neurons in wild-type mice. However, sensory deprivation from P0 or P7 to P12-P14 did not increase PV neurons and sensory deprivation from P7 or P14 to P28 did not decrease or only modestly decreased PV neurons in FcγRllB-/- mice. The results indicate that expression of PV is regulated by sensory experience and the second and third postnatal weeks are a sensitive period for sensory deprivation, and suggest that FcγRllB contributes to sensory experience-regulated expression of PV.
キーワード
parvalbumin
fast-spiking interneurons
FcγRllB
barrel cortex
sensory deprivation
Amo Type
Original Article
発行日
2012-04
出版物タイトル
Acta Medica Okayama
66巻
2号
出版者
Okayama University Medical School
開始ページ
143
終了ページ
154
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT