このエントリーをはてなブックマークに追加
ID 50406
JaLCDOI
フルテキストURL
Thumnail 67_3_135.pdf 1.47 MB
著者
Ueno, Hiroshi Department of Medical Technology, Graduate School of Health Sciences, Okayama University
Shoshi, Chikafumi Department of Medical Technology, Kawasaki College of Allied Health Professions
Suemitsu, Shunsuke Department of Psychiatry, Kawasaki Medical University
Usui, Shinichi Department of Medical Technology, Graduate School of Health Sciences, Okayama University
Sujiura, Hiroko Department of Medical Technology, Graduate School of Health Sciences, Okayama University
Okamoto, Motoi Department of Medical Technology, Graduate School of Health Sciences, Okayama University
抄録
In the phenomenon known as cross-modal plasticity, the loss of one sensory system is followed by improved functioning of other intact sensory systems. MRI and functional MRI studies suggested a role of the prefrontal cortex and the temporal lobe in cross-modal plasticity. We used a mouse model to examine the effects of sensory deprivation achieved by whisker trimming and visual deprivation achieved by dark rearing in neonatal mice on the appearance of parvalbumin (PV) neurons and the formation of glutamic acid decarboxylase 67 (GAD67)-positive puncta around pyramidal neurons in the prefrontal cortex and hippocampus. Whisker trimming, but not dark rearing, decreased the density of PV neurons in the hippocampus at postnatal day 28 (P28). In the prefrontal cortex, whisker trimming and dark rearing decreased the density of PV neurons in layer 5/6 (L5/6) at P28 and in L2/3 at P56, respectively, whereas dark rearing increased the density of PV neurons in L5/6 at P56. Whisker trimming decreased the density of GAD67-positive puncta in CA1 of the hippocampus at both P28 and P56 and in L5/6 of the prefrontal cortex at P28. Dark rearing decreased the density of GAD67-positive puncta in CA1 of the hippocampus and in both L2/3 and L5/6 of the prefrontal cortex at P28, and in L2/3 of the prefrontal cortex at P56. These results demonstrate that somatosensory or visual deprivation causes changes in the PV-interneuronal network in the mouse prefrontal cortex and hippocampus. The results also suggest that the alteration of the PV-interneuronal network, especially in the prefrontal cortex, may contribute to cross-modal plasticity.
キーワード
sensory deprivation
parvalbumin
glutamate decarboxylase (GAD67)
prefrontal cortex
hippocampus
Amo Type
Original Article
発行日
2013-06
出版物タイトル
Acta Medica Okayama
67巻
3号
出版者
Okayama University Medical School
開始ページ
135
終了ページ
143
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/50870