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ID 61438
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75_1_79.pdf 2.07 MB
著者
Yoshio, Kotaro Department of Radiology, Kagawa Prefectural Central Hospital
Nagasaka, Hisako Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Hisazumi, Kento Department of Radiology, Kagawa Prefectural Central Hospital
Okawa, Hiro Department of Radiology, Kagawa Prefectural Central Hospital
Tajiri, Nobuhisa Department of Radiology, Kagawa Prefectural Central Hospital
Shiode, Tsuyoki Department of Radiology, Kagawa Prefectural Central Hospital
Akaki, Shiro Department of Radiology, Kagawa Prefectural Central Hospital
Kanazawa, Susumu Department of Radiology, Okayama University Hospital Kaken ID publons
Mitoma, Tomohiro Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Yano, Yuri Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Kobayashi, Emiko Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Horiguchi, Ikuyo Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Takata, Masayo Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Hongo, Atsushi Department of Obstetrics and Gynecology 2, Kawasaki Medical School, General medical Center Kaken ID publons researchmap
Yonezawa, Masaru Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Nakanishi, Yoshie Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
抄録
The purposes of this retrospective study were to analyze local control of squamous cell carcinoma of the cervix treated with computed tomography (CT)-based image-guided brachytherapy (IGBT), as well as the factors affecting local control. A total of 39 patients were analyzed. The prescribed dose to the pelvis was 45-50 Gy with or without central shielding (CS). IGBT was delivered in 1-5 fractions. The total dose for high-risk clinical target volume (HR-CTV) was calculated as the biologically equivalent dose in 2-Gy fractions. The median follow-up period was 29.3 months. The 2-year overall survival and local control rates were 97% and 91%, respectively. In univariate analysis, the dose covering 90% of the HR-CTV (D90) and tumor size were found to be significant factors for local control. The cutoff values of tumor size and D90 for local control were 4.3 cm (area under the curve [AUC] 0.75) and 67.7 Gy (AUC 0.84) in the CS group and 5.3 cm (AUC 0.75) and 73.7 Gy (AUC 0.78) in the group without CS, respectively. However, though the local control of CT-based IGBT was favorable, the results suggested that the dose required for tumor control may differ depending on the presence of CS.
キーワード
cervical cancer
squamous cell cancer
brachytherapy
central shielding
Amo Type
Original Article
発行日
2021-02
出版物タイトル
Acta Medica Okayama
75巻
1号
出版者
Okayama University Medical School
開始ページ
79
終了ページ
85
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID