| JaLCDOI | 10.18926/AMO/60806 |
|---|---|
| フルテキストURL | 74_5_443.pdf |
| 著者 | Sekito, Takanori| Araki, Motoo| Hiraki, Takao| Uka, Mayu| Komaki, Toshiyuki| Matsui, Yusuke| Iguchi, Toshihiro| Katayama, Satoshi| Yoshinaga, Kasumi| Watari, Shogo| Maruyama, Yuki| Mitsui, Yosuke| Kubota, Risa| Sadahira, Takuya| Nishimura, Shingo| Wada, Koichiro| Takamoto, Atsushi| Edamura, Kohei| Sako, Tomoko| Kobayashi, Yasuyuki| Watanabe, Toyohiko| Kanazawa, Susumu| Nasu, Yasutomo| |
| 抄録 | We report a 47-year-old Japanese female with 10 previous treatments for multiple bilateral renal cell carcinoma (RCC) associated with von Hippel-Lindau disease. The 14-mm right lower pole renal tumor was in contact with the right ureter. Laparoscopic cryoablation was performed to protect the ureter wrapped with gauze. Computed tomography (CT) monitoring was used to confirm the precise ≥ 6 mm ice-ball margin. There was no local progression at 6-months post-surgery. The serum creatinine has been stable. This is apparently the first report of combined laparoscopic and CT monitoring of an ice-ball formation and its margin during cryoablation for RCC. |
| キーワード | laparoscopic cryoablation multiple renal masses nephron-sparing surgery renal cell carcinoma von Hippel-Lindau disease |
| Amo Type | Case Report |
| 備考 | Fig. 1B is replaced on Dec. 23, 2020.| |
| 発行日 | 2020-10 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 74巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 443 |
| 終了ページ | 448 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33106702 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Katayama, Norihisa| Katsui, Kuniaki| Watanabe, Kenta| Nagao, Ryota| Otsuki, Kaho| Hiraki, Takao| Kanazawa, Susumu| |
| キーワード | Bone metastasis breast cancer (BCa) oligometastatic radiation therapy (RT) stereotactic body radiation therapy (SBRT) |
| 発行日 | 2020-08 |
| 出版物タイトル | Translational Cancer Research |
| 巻 | 9巻 |
| 号 | 8号 |
| 出版者 | AME Publoshing Company |
| 開始ページ | 5096 |
| 終了ページ | 5101 |
| ISSN | 2218-676X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © Translational Cancer Research. All rights reserved. |
| 論文のバージョン | publisher |
| DOI | 10.21037/tcr.2020.01.35 |
| Web of Science KeyUT | 000562138400066 |
| 関連URL | isVersionOf https://doi.org/10.21037/tcr.2020.01.35 |
| JaLCDOI | 10.18926/AMO/59951 |
|---|---|
| フルテキストURL | 74_3_209.pdf |
| 著者 | Matsui, Yusuke| Hiraki, Takao| Iguchi, Toshihiro| Sakurai, Jun| Uka, Mayu| Masaoka, Yoshihisa| Gobara, Hideo| Kanazawa, Susumu| |
| 抄録 | An aspiration-type semi-automatic cutting biopsy needle enables tissue cutting during application of negative pressure, which is expected to contribute to a larger amount of specimen. The aim of the present study was to evaluate this novel needle in a clinical setting. Patients who underwent image-guided percutaneous biopsy for lung or renal masses were enrolled. Cutting biopsy was performed with and without aspiration during each procedure. The specimens were weighed using an electronic scale. The weights were compared between specimens obtained with and without aspiration using a paired t-test. The data from 45 lung and 30 renal biopsy procedures were analyzed. In lung biopsy, the mean±standard deviation weights of specimens obtained with and without aspiration were 2.20±1.05 mg and 2.24±1.08 mg, respectively. In renal biopsy, the mean weights were 6.52±2.18 mg and 6.42±1.62 mg, respectively. The weights were not significantly different between specimens obtained with and without aspiration either in lung (p=0.799) or renal (p=0.789) biopsies. The application of negative pressure with the aspiration-type semi-automatic cutting biopsy needle did not contribute to an increase in the amount of the specimen obtained in lung and renal biopsies. |
| キーワード | biopsy cutting needle aspiration clinical study |
| Amo Type | Original Article |
| 発行日 | 2020-06 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 74巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 209 |
| 終了ページ | 214 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32577018 |
| Web of Science KeyUT | 000543363400004 |
| NAID | 120006862793 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Katsui, Kuniaki| Ogata, Takeshi| Watanabe, Kenta| Katayama, Norihisa| Kuroda, Masahiro| Kiura, Katsuyuki| Hiraki, Takao| Maeda, Yoshinobu| Toyooka, Shinichi| Kanazawa, Susumu| |
| キーワード | cisplatin docetaxel dose-volume histogram non-small cell lung cancer PACIFIC trial radiation pneumonitis |
| 発行日 | 2020-05-04 |
| 出版物タイトル | Cancer Medicine |
| 出版者 | Wiley |
| ISSN | 2045-7634 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2020 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 32364685 |
| DOI | 10.1002/cam4.3093 |
| Web of Science KeyUT | 000530411600001 |
| 関連URL | isVersionOf https://doi.org/10.1002/cam4.3093 |
| JaLCDOI | 10.18926/AMO/58271 |
|---|---|
| フルテキストURL | 74_2_129.pdf |
| 著者 | Fukuma, Shogo| Shinya, Takayoshi| Soh, Junichi| Fukuhara, Ryuichiro| Ogawa, Nanako| Higaki, Fumiyo| Tanaka, Takehiro| Ichihara, Eiki| Hiraki, Takao| Toyooka, Shinichi| Kanazawa, Susumu| |
| 抄録 | The aim of this study was to explore enhancement patterns of different types of primary lung cancers on 2-phase dynamic computed tomography (CT). This study included 217 primary lung cancer patients (141 adenocarcinomas [ADs], 48 squamous cell carcinomas [SCCs], 20 small cell lung carcinomas [SCLCs], and 8 others) who were examined using a 2-phase dynamic scan. Regions of interest were identified and mean enhancement values were calculated. After excluding the 20 SCLCs because these lesions had different clinical stages from the other cancer types, the mean attenuation values and subtractions between phases were compared between types of non-small cell lung carcinomas (NSCLCs) using the Kruskal–Wallis test. Late phase attenuation and attenuation of the late minus unenhanced phase (LMU) of SCCs were significantly higher than those of ADs (p<0.05). To differentiate SCC and AD in the late phase, a threshold of 80.21 Hounsfield units (HU) gave 52.9% accuracy. In LMU, a threshold of 52.16 HU gave 59.3% accuracy. Dynamic lung CT has the potential to aid in differentiating among NSCLC types. |
| キーワード | differentiation dynamic computed tomography primary lung cancer enhancement pattern |
| Amo Type | Original Article |
| 発行日 | 2020-04 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 74巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 129 |
| 終了ページ | 135 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32341587 |
| Web of Science KeyUT | 000528278500006 |
| NAID | 120006839450 |
| JaLCDOI | 10.18926/AMO/58270 |
|---|---|
| フルテキストURL | 74_2_123.pdf |
| 著者 | Fukuhara, Ryuichiro| Shinya, Takayoshi| Fukuma, Shogo| Ogawa, Nanako| Masaoka, Yoshihisa| Tanaka, Takehiro| Marunaka, Hidenori| Arioka, Tadashi| Hiraki, Takao| Kaji, Mitsumasa| Kanazawa, Susumu| |
| 抄録 | The aim of this study was to evaluate the ability of pretreatment 90-min 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to predict the extranodular spread of lymph node metastases in oral squamous cell carcinoma. We retrospectively reviewed the cases of 56 patients who underwent pretreatment 18F-FDG PET/CT and surgery with neck dissection. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were measured for the 56 primary sites and maximum standardized uptake value was measured for 115 lymph node levels. Extranodular spread was present at 9 lymph node levels in 7 patients. Significant differences were found in metabolic tumor volume and total lesion glycolysis of the primary site, and in lymph node maximum standardized uptake value, between patients with and without extranodular spread (p<0.05). Combining primary site total lesion glycolysis and lymph node maximum standardized uptake volume at their respective optimal cutoffs, the sensitivity, specificity, and accuracy for predicting extranodular spread were 89%, 92%, and 92%, respectively. Pretreatment 18F-FDG PET/CT is useful for predicting extranodular spread in patients with oral squamous cell carcinoma. The combined use of primary site total lesion glycolysis and lymph node maximum standardized uptake value showed greater predictive value than either predictor singly. |
| キーワード | 18F-fluorodeoxyglucose positron emission tomography/computed tomography extranodular spread metastasis oral squamous cell carcinoma |
| Amo Type | Original Article |
| 発行日 | 2020-04 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 74巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 123 |
| 終了ページ | 128 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32341586 |
| Web of Science KeyUT | 000528278500005 |
| NAID | 120006839449 |
| 著者 | Shinya, Takayoshi| Masaoka, Yoshihisa| Sando, Motohiro| Tanabe, Shin| Okamoto, Soichiro| Ihara, Hiroki| Tanaka, Takehiro| Otani, Shinji| Hiraki, Takao| Kanazawa, Susumu| |
|---|---|
| キーワード | Solitary fibrous tumor (SFT) Intrapulmonary Computed tomography (CT) |
| 発行日 | 2019-06 |
| 出版物タイトル | Radiology Case Reports |
| 巻 | 14巻 |
| 号 | 6号 |
| 出版者 | Elsevier |
| 開始ページ | 755 |
| 終了ページ | 758 |
| ISSN | 1930-0433 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2019 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 30992735 |
| DOI | 10.1016/j.radcr.2019.03.023 |
| 関連URL | isVersionof https://doi.org/10.1016/j.radcr.2019.03.023 |
| JaLCDOI | 10.18926/AMO/54817 |
|---|---|
| フルテキストURL | 70_6_511.pdf |
| 著者 | Gobara, Hideo| Hiraki, Takao| Iguchi, Toshihiro| Fujiwara, Hiroyasu| Nagasaka, Takeshi| Kishimoto, Hiroyuki| Tanaka, Takehiro| Kanazawa, Susumu| |
| 抄録 | An 87-year-old Japanese man underwent percutaneous cryoablation (PCA) therapy for his renal cell tumor. We displaced the colon from the tumor using hydrodissection. Computed tomography (CT) immediately after PCA was indicative of iceball extension to the colon wall, and a discontinuous enhancement of the colon wall was observed. We therefore performed an emergency surgery. On laparotomy, we observed a dark-purple area on the affected area of the colon, and the resected specimen showed focal, deep ulceration on the mucosal surface. Photomicrography revealed mucosal necrosis, submucosal hemorrhage, and necrotic foci in the muscularis propria, corresponding to the discontinuous colon wall enhancement on CT and the deep ulceration and dark-purple area on laparotomy. He recovered from surgery and was discharged without any complications. |
| キーワード | bowel injury complication cryoablation renal cell carcinoma thermal ablation |
| Amo Type | Case Report |
| 発行日 | 2016-12 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 70巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 511 |
| 終了ページ | 514 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28003679 |
| JaLCDOI | 10.18926/AMO/54512 |
|---|---|
| フルテキストURL | 70_4_317.pdf |
| 著者 | Sakurai, Jun| Matsui, Yusuke| Hiraki, Takao| Iguchi, Toshihiro| Fujiwara, Hiroyasu| Gobara, Hideo| Mitsuhashi, Toshiharu| Nagasaka, Takeshi| Susumu Kanazawa, Susumu Kanazawa| |
| 抄録 | The present single center prospective phase II clinical trial is designed to evaluate the efficacy and safety of percutaneous radiofrequency (RF) ablation for colorectal lung metastases. Patients who have colorectal lung metastases without extrapulmonary metastases are included in this study. The primary endpoint is 3-year overall survival (OS) after RF ablation. The secondary endpoints are the prevalence of adverse events within 4 weeks, local tumor progression rate, 1- and 5-year OS, cause-specific survival, and relapse-free survival. The recruitment of patients commenced in July 2014, and the enrolment of 45 patients is intended over the 3 years of study period. |
| キーワード | radiofrequency ablation colorectal cancer lung metastasis |
| Amo Type | Clinical Study Protocols |
| 発行日 | 2016-08 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 70巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 317 |
| 終了ページ | 321 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 27549681 |
| Web of Science KeyUT | 000384748600016 |
| JaLCDOI | 10.18926/AMO/54509 |
|---|---|
| フルテキストURL | 70_4_303.pdf |
| 著者 | Iguchi, Toshihiro| Sakurai, Jun| Hiraki, Takao| Gobara, Hideo| Fujiwara, Hiroyasu| Matsui, Yusuke| Masaoka, Yoshihisa| Kanazawa, Susumu| |
| 抄録 | This single center prospective study is being conducted to evaluate the safety of the cryoablation for patients with pathologically diagnosed painful bone and soft tissue tumors. Enrollment of 10 patients is planned over the 3-year recruitment period. Patients have related local pain after receiving medications or external radiation therapies will be included in this study. Cryoablation will be percutaneously performed under imaging guidance, and a temperature sensor will be used during treatment as necessary. The primary endpoint is prevalence of severe adverse events within 4 weeks after therapy. The secondary endpoint is effectiveness 4 weeks after the procedure. |
| キーワード | cryoablation soft tissue and bone tumor pain safety |
| Amo Type | Clinical Study Protocols |
| 発行日 | 2016-08 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 70巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 303 |
| 終了ページ | 306 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 27549678 |
| Web of Science KeyUT | 000384748600013 |
| JaLCDOI | 10.18926/AMO/53340 |
|---|---|
| フルテキストURL | 69_2_113.pdf |
| 著者 | Inada, Ryo| Nagasaka, Takeshi| Toshima, Toshiaki| Mori, Yoshiko| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Hiraki, Takao| Oshiro, Taihei| Kanemitsu, Yukihide| Fujiwara, Toshiyoshi| |
| 抄録 | A case of advanced rectal cancer treated by aggressive local and systemic treatment who has survived more than 7 years from initial recurrence is presented. A 55-year-old woman was diagnosed with advanced lower rectal cancer and underwent a low anterior resection with complete removal of all regional lymph nodes and total mesorectal excision. The tumor was diagnosed as a moderately differentiated adenocarcinoma, pStage IIIB (T3, N2a, M0). Twenty-six months after the initial surgery, local recurrence in the pelvis was detected by computed tomography, and total pelvic exenteration with distal sacrectomy (TPES) was performed after systemic chemotherapy with a molecular-targeted drug. Six months after the TPES, multiple lung metastases were detected. Consequently, the patient underwent radiofrequency ablation (RFA) and chemotherapy. The disease has since been controlled for 38 months. As volume control is essential for cancer treatment, it may be important to combine appropriate local therapy with systemic therapy to metastatic or recurrent sites in order to achieve much longer disease control. |
| キーワード | colorectal cancer recurrence total pelvic exenteration radiofrequency ablation systemic chemotherapy |
| Amo Type | Case Report |
| 発行日 | 2015-04 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 69巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 113 |
| 終了ページ | 118 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25899633 |
| Web of Science KeyUT | 000353181700006 |
| JaLCDOI | 10.18926/AMO/51909 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Mimura, Hidefumi| Kanazawa, Susumu| Yasui, Kotaro| Fujiwara, Hiroyasu| Hyodo, Tsuyoshi| Mukai, Takashi| Dendo, Shuichi| Iguchi, Toshihiro| Hiraki, Takao| Koshima, Isao| Hiraki, Yoshio| |
| 抄録 | <p>This retrospective study evaluated the safety and efficacy of using polidocanol with X-ray fluoroscopy for percutaneous sclerotherapy of venous malformations of the limbs, head, and neck. The subjects were 16 of 18 patients who presented to our department with venous malformations. Two patients were excluded because they were unlikely to benefit from the treatment. Of the 16 included in the study, 1 could not be treated because of inaccessibility, and another was lost to follow-up. Among the 14 cases that we were able to follow-up, 11 cases had had pain as their primary symptom. Following treatment, this symptom remained unchanged in 1 patient, was improved in 4, and had disappeared in 6; however, there was a recurrence of pain for 3 of these patients. Two patients had sought treatment for cosmetic purposes; following treatment, the lesion disappeared in one and showed a significant reduction in the other. The remaining patient presented with a primary symptom of mouth bleeding, which disappeared following treatment. There were no critical complications. Percutaneous sclerotherapy of venous malformations using polidocanol is safe and effective, and permits repeat treatments. The efficacy is especially good for resolving pain, and complications are minor. It is desirable to use fluoroscopy for these procedures</p> |
| キーワード | venous malformation sclerotherapy polidocanol fluoroscopy guidance |
| Amo Type | Article |
| 発行日 | 2003-10 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 57巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 227 |
| 終了ページ | 234 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 14679400 |
| Web of Science KeyUT | 000186186000003 |
| JaLCDOI | 10.18926/AMO/49669 |
|---|---|
| フルテキストURL | 67_2_105.pdf |
| 著者 | Alafate, Aierken| Shinya, Takayoshi| Okumura, Yoshihiro| Sato, Shuhei| Hiraki, Takao| Ishii, Hiroaki| Gobara, Hideo| Kato, Katsuya| Fujiwara, Toshiyoshi| Miyoshi, Shinichiro| Kaji, Mitsumasa| Kanazawa, Susumu| |
| 抄録 | We retrospectively evaluated the accumulation of fluorodeoxy glucose (FDG) in pulmonary malignancies without local recurrence during 2-year follow-up on positron emission tomography (PET)/computed tomography (CT) after radiofrequency ablation (RFA). Thirty tumors in 25 patients were studied (10 non-small cell lung cancers;20 pulmonary metastatic tumors). PET/CT was performed before RFA, 3 months after RFA, and 6 months after RFA. We assessed the FDG accumulation with the maximum standardized uptake value (SUVmax) compared with the diameters of the lesions. The SUVmax had a decreasing tendency in the first 6 months and, at 6 months post-ablation, FDG accumulation was less affected by inflammatory changes than at 3 months post-RFA. The diameter of the ablated lesion exceeded that of the initial tumor at 3 months post-RFA and shrank to pre-ablation dimensions by 6 months post-RFA. SUVmax was more reliable than the size measurements by CT in the first 6 months after RFA, and PET/CT at 6 months post-RFA may be more appropriate for the assessment of FDG accumulation than that at 3 months post-RFA. |
| キーワード | fluorodeoxy glucose (FDG) positron emission tomography (PET) standardized uptake value (SUV) radiofrequency ablation (RFA) non-small cell lung cancer (NSCLC) |
| Amo Type | Original Article |
| 発行日 | 2013-04 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 67巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 105 |
| 終了ページ | 112 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23603927 |
| Web of Science KeyUT | 000317801700005 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/50688 |
| JaLCDOI | 10.18926/AMO/47265 |
|---|---|
| フルテキストURL | 65_6_395.pdf |
| 著者 | Harada, Sosuke| Sato, Shuhei| Suzuki, Etsuji| Okumura, Yoshihiro| Hiraki, Takao| Gobara, Hideo| Mimura, Hidefumi| Kanazawa, Susumu| Kaji, Mitsumasa| Fujiwara, Toshiyoshi| |
| 抄録 | The aim of the present study was to assess the diagnostic usefulness of Fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in the prediction of local recurrence of malignant lung tumors by analyzing the pre-radiofrequency ablation (RFA) maximal standardized uptake value (SUVmax). We performed a historical cohort study of consecutive malignant lung tumors treated by RFA from January 2007 to May 2008 at Okayama University Hospital. We selected only lung tumors examined by PET/CT within 90 days before RFA and divided them (10 primary and 29 metastatic) into 3 groups according to their tertiles of SUVmax. We calculated recurrence odds ratios in the medium group and the high group compared to the low group using multivariate logistic analysis. After we examined the relationship between SUVmax and recurrence in a crude model, we adjusted for some factors. Tumors with higher SUVmax showed higher recurrence odds ratios (medium group;1.84, high group;4.14, respectively). The tumor size also increased the recurrence odds ratio (2.67);we thought this was mainly due to selection bias because we excluded tumors less than 10mm in diameter. This study demonstrated the pre-RFA SUVmax in PET/CT may be a prognostic factor for local recurrence of malignant lung tumors. |
| キーワード | fluorodeoxyglucose (FDG) positron emission tomography (PET) standardized uptake value (SUV) radiofrequency ablation (RFA) lung |
| Amo Type | Original Article |
| 発行日 | 2011-12 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 65巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 395 |
| 終了ページ | 402 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22189480 |
| Web of Science KeyUT | 000298516900006 |
| JaLCDOI | 10.18926/AMO/47010 |
|---|---|
| フルテキストURL | 65_5_287.pdf |
| 著者 | Hiraki, Takao| Gobara, Hideo| Mimura, Hidefumi| Toyooka, Shinichi| Fujiwara, Hiroyasu| Yasui, Kotaro| Sano, Yoshifumi| Iguchi, Toshihiro| Sakurai, Jun| Tajiri, Nobuhisa| Mukai, Takashi| Matsui, Yusuke| Kanazawa, Susumu| |
| 抄録 | The application of radiofrequency ablation for the treatment of lung cancer by our group at Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences began in June 2001, and in the present report, we review our 10-year experience with this treatment modality at Okayama University Hospital. The local efficacy of radiofrequency ablation for the treatment of lung cancer depends on tumor size and the type of electrode used, but not on tumor type. An important factor for the prevention of local failure may be the acquisition of an adequate ablative margin. The combination of embolization and radiation therapy enhances the local efficacy. Local failure may be salvaged by repeating the radiofrequency ablation, particularly in small tumors. Survival rates after radiofrequency ablation are quite promising for patients with clinical stage I non-small cell lung cancer and pulmonary metastasis from colorectal cancer, hepatocellular carcinoma, and renal cell carcinoma. The complications caused by radiofrequency ablation can be treated conservatively in the majority of cases. However, attention should be paid to rare but serious complications. This review shows that radiofrequency ablation is a promising treatment for patients with lung cancer. |
| キーワード | radiofrequency ablation lung cancer local efficacy survival complication |
| Amo Type | Review |
| 発行日 | 2011-10 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 65巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 287 |
| 終了ページ | 297 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22037265 |
| Web of Science KeyUT | 000296116400002 |
| JaLCDOI | 10.18926/AMO/32906 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Mukai, Takashi| Mimura, Hidefumi| Gobara, Hideo| Takemoto, Mitsuhiro| Himei, Kengo| Hiraki, Takao| Hase, Soichiro| Fujiwara, Hiroyasu| Iguchi, Toshihiro| Tajiri, Nobuhisa| Sakurai, Jun| Yasui, Kotaro| Sano, Yoshifumi| Date, Hiroshi| Kanazawa, Susumu| |
| 抄録 | We report the clinical experience of radiofrequency ablation followed by radiation therapy for large primary lung tumors. Two patients with large primary lung tumors were treated with combined radiofrequency ablation and radiation therapy, and good local control was observed. Combined radiofrequency ablation and radiation therapy that involves minimally invasive techniques appears to be promising for the treatment of large lung tumors. |
| キーワード | radiofrequency ablation lung cancer radiation therapy |
| Amo Type | Case Report |
| 発行日 | 2007-06 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 61巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 177 |
| 終了ページ | 180 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17593954 |
| Web of Science KeyUT | 000247574700008 |
| JaLCDOI | 10.18926/AMO/32095 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Fujiwara, Hiroyasu| Kanazawa, Susumu| Hiraki, Takao| Mimura, Hidefumi| Yasui, Kotaro| Akaki, Shiro| Yagi, Takahito| Naomoto, Yoshio| Tanaka, Noriaki| Hiraki, Yoshio| |
| 抄録 | <p>To clarify the incidence, background, and progress of hepatic infarction following interventional procedures, cases of hepatic infarction following interventional procedures at our department during the last decade were identified by reviewing the clinical records of 1982 abdominal angiography and interventional procedures and records of abdominal CT. Nine episodes (0.5%) in 8 patients were identified as hepatic infarction following an interventional procedure. Five episodes were preceded by embolization of the hepatic or celiac artery at emergency angiography for postoperative bleeding with hemorrhagic shock. Three episodes followed the elected interventional procedure for hepatocellular carcinoma, and the remaining episode occurred after 12 months of chemoinfusion through an indwelling catheter in the hepatic artery and portal vein. Hepatic arterial occlusion in all episodes and portal venous flow abnormality in 5 episodes were observed on angiography. Four patients whose liver function was initially impaired died of hepatic infarction, although the extent of the disease on CT did not appear to be related to the mortality. Multiple risk factors, including arterial insufficiency, were observed in each patient. The incidence of hepatic infarction following interventional procedures in this series was low but sometimes fatal, and occurred most frequently in emergency embolization in hemorrhagic shock.</p> |
| キーワード | liver infarction interventional procedure angiography computedtomography |
| Amo Type | Article |
| 発行日 | 2004-04 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 58巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 97 |
| 終了ページ | 106 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 15255511 |
| Web of Science KeyUT | 000221043700006 |
| JaLCDOI | 10.18926/AMO/31975 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Hiraki, Takao| Kanazawa, Susumu| |
| 抄録 | <p>Hepatic outflow obstruction created by balloon occlusion of the hepatic vein induces characteristic angiographic findings in the occluded area: prolonged enhancement on hepatogram followed by reversed portal opacification on the hepatic arteriogram and perfusion defect on the arterial portogram. The following induced hepatic hemodynamic changes are suggested: hepatic arterial flow increases, and the portal vein acts as a draining vein with slow reversed flow. These unique hemodynamic changes enhance the effect of hepatic interventional therapies. In transcatheter arterial infusion, increasing hepatic arterial flow and absence of portal inflow can bring about a high concentration of drugs, the presence of which is greatly protracted due to outflow blockage. In transcatheter arterial chemoembolization, reversed portal flow can allow portal embolization in addition to arterial embolization. In microwave coagulation therapy and radiofrequency ablation therapy, decreasing portal flow can cause larger areas of coagulation. Further, the technique of hepatic venous occlusion has potential therapeutic applications.</p> |
| キーワード | liver hepatic vein obstruction blood supply therapy |
| Amo Type | Letter to the Editor |
| 発行日 | 2005-10 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 59巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 171 |
| 終了ページ | 178 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 16286956 |
| Web of Science KeyUT | 000232835600001 |
| JaLCDOI | 10.18926/AMO/31848 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Iishi, Tatsuhiko| Hiraki, Takao| Mimura, Hidefumi| Gobara, Hideo| Kurose, Taichi| Fujiwara, Hiroyasu| Sakurai, Jun| Yanai, Hiroyuki| Yoshino, Tadashi| Kanazawa, Susumu| |
| 抄録 | <p>The present study was performed to clarify the effect of hypertonic saline infusion into the lung parenchyma on radiofrequency ablation (RFA) of the lungs. A total of 20 ablation zones were created in 3 pigs. The ablation zones were divided into 3 groups. Group 1 (n6) consisted of ablation zones created by applying smaller radiofrequency (RF) power without saline infusion;group 2 (n5) zones were created by applying greater RF power without saline infusion;and group 3 (n9) zones were created by applying greater RF power with saline infusion. The techniques of saline infusion included administration of hypertonic saline 1ml before RFA, followed by continuous administration at a rate of 1ml/min during the first 2min after the initiation of RFA. The ablation parameters and coagulation necrosis volumes were compared among the groups. Group 3 had a tendency toward smaller mean impedance than group 1 (p0.059) and group 2 (p0.053). Group 3 showed significantly longer RF application time than group 2 (p0.004) and significantly greater maximum RF power than group 1 (p0.001) and group 2 (p0.004). Group 3 showed significantly larger coagulation necrosis volume (mean, 1,421mm3) than group 2 (mean, 858mm3, p0.039) and had a tendency toward larger necrosis volume than group 1 (mean, 878mm3, p0.077). Although this small study had limited statistical power, hypertonic saline infusion during RFA appeared to enlarge coagulation necrosis of the lung parenchyma.</p> |
| キーワード | radiofrequency ablation lung experimental study |
| Amo Type | Original Article |
| 発行日 | 2009-06 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 63巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 137 |
| 終了ページ | 144 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 19571900 |
| Web of Science KeyUT | 000267388200003 |
| 著者 | 三村 秀文| 藤原 寛康| 平木 隆夫| 郷原 英夫| 芝本 健太郎| 木股 敬裕| 尾﨑 敏文| 佐々木 了| 金澤 右| |
|---|---|
| 発行日 | 2010-04-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |