岩崎良章

A novel model of liver cancer stem cells developed from induced pluripotent stem cells

フルテキストURL	fulltext.pdf
著者	Afify, Said M.\| Calle, Anna Sanchez\| Hassan, Ghmkin\| Kumon, Kazuki\| Nawara, Hend M.\| Zahra, Maram H.\| Mansour, Hager M.\| Khayrani, Apriliana Cahya\| Alam, Md Jahangir\| Du, Juan\| Seno, Akimasa\| Iwasaki, Yoshiaki\| Seno, Masaharu\|
キーワード	Cancer models Cancer stem cells
発行日	2020-03-17
出版物タイトル	British Journal of Cancer
巻	122巻
号	9号
出版者	Springer Nature
開始ページ	1378
終了ページ	1390
ISSN	0007-0920
NCID	AA00574355
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© Authors
論文のバージョン	publisher
PubMed ID	32203212
DOI	10.1038/s41416-020-0792-z
Web of Science KeyUT	000519841900001
関連URL	isVersionOf https://doi.org/10.1038/s41416-020-0792-z

Association between Household Exposure to Secondhand Smoke and Dental Caries among Japanese Young Adults: A Cross-Sectional Study

フルテキストURL	fulltext.pdf
著者	Saho, Hikari\| Taniguchi-Tabata, Ayano\| Ekuni, Daisuke\| Yokoi, Aya\| Kataoka, Kouta\| Fukuhara, Daiki\| Toyama, Naoki \| Islam, Md Monirul\| Sawada, Nanami\| Nakashima, Yukiho\| Nakahara, Momoko\| Deguchi, Junya\| Uchida-Fukuhara, Yoko\| Yoneda, Toshiki\| Iwasaki, Yoshiaki\| Morita, Manabu\|
キーワード	secondhand smoke dental caries permanent dentition young adult
発行日	2020-11-20
出版物タイトル	International Journal of Environmental Research and Public Health
巻	17巻
号	22号
出版者	MDPI
開始ページ	8623
ISSN	1660-4601
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	33233610
DOI	10.3390/ijerph17228623
Web of Science KeyUT	000594343500001
関連URL	isVersionOf https://doi.org/10.3390/ijerph17228623

Relationship between oral hygiene knowledge, source of oral hygiene knowledge and oral hygiene behavior in Japanese university students: A prospective cohort study

フルテキストURL	fulltext.pdf
著者	Fukuhara, Daiki\| Ekuni, Daisuke\| Kataoka, Kota\| Taniguchi-Tabata, Ayano\| Uchida-Fukuhara, Yoko\| Toyama, Naoki \| Yoneda, Toshiki\| Sugiura, Yoshio\| Islam, Monirul\| Saho, Hikari\| Iwasaki, Yoshiaki\| Morita, Manabu\|
発行日	2020-07-23
出版物タイトル	PLoS ONE
巻	15巻
号	7号
出版者	Public Library of Science
開始ページ	e0236259
ISSN	1932-6203
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2020 Fukuhara et al.
論文のバージョン	publisher
PubMed ID	32702010
DOI	10.1371/journal.pone.0236259
Web of Science KeyUT	000575913700064
関連URL	isVersionOf https://doi.org/10.1371/journal.pone.0236259

Caries Increment and Salivary Microbiome during University Life: A Prospective Cohort Study

フルテキストURL	fulltext.pdf
著者	Uchida-Fukuhara, Yoko\| Ekuni, Daisuke\| Islam, Md Monirul\| Kataoka, Kota\| Taniguchi-Tabata, Ayano\| Fukuhara, Daiki\| Toyama, Naoki \| Kobayashi, Terumasa\| Fujimori, Kohei\| Sawada, Nanami\| Iwasaki, Yoshiaki\| Morita, Manabu\|
キーワード	salivary microbiome sequence analysis young adult dental caries saliva oral health
発行日	2020-05-25
出版物タイトル	International Journal of Environmental Research and Public Health
巻	17巻
号	10号
出版者	MDPI
開始ページ	3713
ISSN	1660-4601
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	32466124
DOI	10.3390/ijerph17103713
Web of Science KeyUT	000539300900370
関連URL	isVersionOf https://doi.org/10.3390/ijerph17103713

Association between Sleep Quality and Duration and Periodontal Disease among University Students: A Cross-Sectional Study

フルテキストURL	fulltext.pdf
著者	Islam, Md Monirul\| Ekuni, Daisuke\| Toyama, Naoki \| Taniguchi-Tabata, Ayano\| Kataoka, Kota\| Uchida-Fukuhara, Yoko\| Fukuhara, Daiki\| Saho, Hikari\| Sawada, Nanami\| Nakashima, Yukiho\| Iwasaki, Yoshiaki\| Morita, Manabu\|
キーワード	sleep quality sleep duration periodontal disease university students
発行日	2020-04-27
出版物タイトル	International Journal of Environmental Research and Public Health
巻	17巻
号	9号
出版者	MDPI
ISSN	1660-4601
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	32349308
DOI	10.3390/ijerph17093034
Web of Science KeyUT	000535745400058
関連URL	isVersionOf https://doi.org/10.3390/ijerph17093034

Relationship of Salivary Microbiome with the Worsening of the Periodontal Health Status in Young Adults: A 3-Year Cohort Study

フルテキストURL	fulltext.pdf
著者	Islam, Md Monirul\| Ekuni, Daisuke\| Toyama, Naoki \| Kobayashi, Terumasa\| Fujimori, Kohei\| Uchida, Yoko\| Fukuhara, Daiki\| Taniguchi-Tabata, Ayano\| Kataoka, Kota\| Iwasaki, Yoshiaki\| Morita, Manabu\|
キーワード	salivary microbiome periodontal health status oral hygiene cohort study young adults
発行日	2020-03-09
出版物タイトル	International Journal of Environmental Research and Public Health
巻	17巻
号	5号
出版者	MDPI
開始ページ	1764
ISSN	1660-4601
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	32182740
DOI	10.3390/ijerph17051764
Web of Science KeyUT	000522389200304
関連URL	isVersionOf https://doi.org/10.3390/ijerph17051764

Cancer stem cell induction from mouse embryonic stem cells

フルテキストURL	OL18_3_2756.pdf
著者	Seno, Akimasa\| Murakami, Chikae\| El‑Aarag, Bishoy\| Iwasaki, Yoshiaki\| Ohara, Toshiaki\| Seno, Masaharu\|
キーワード	cancer stem cell conditioned medium mouse embryonic stem cells
発行日	2019-09
出版物タイトル	Oncology Letters
巻	18巻
号	3号
出版者	Spandidos Publications
開始ページ	2756
終了ページ	2762
ISSN	1792-1074
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© Seno et al.
論文のバージョン	publisher
PubMed ID	31452753
DOI	10.3892/ol.2019.10614
Web of Science KeyUT	000487675500075
関連URL	isVersionOf https://doi.org/10.3892/ol.2019.10614

The level of salivary lactate dehydrogenase as an indicator of the association between gingivitis and related factors in Japanese university students

フルテキストURL	JOC61_1_133.pdf
著者	Taniguchi-Tabata, Ayano\| Ekuni, Daisuke\| Azuma, Tetsuji\| Yoneda, Toshiki\| Yamane-Takeuchi, Mayu\| Kataoka, Kota\| Mizuno, Hirofumi\| Miyai, Hisataka\| Iwasaki, Yoshiaki\| Morita, Manabu\|
キーワード	lactate dehydrogenase gingivitis; screening young adults cross-sectional study
発行日	2019-03-28
出版物タイトル	Journal of Oral Science
巻	61巻
号	1号
出版者	Nihon University School of Dentistry
開始ページ	133
終了ページ	139
ISSN	1343-4934
NCID	AA11208439
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
論文のバージョン	publisher
PubMed ID	30814390
DOI	10.2334/josnusd.18-0038
Web of Science KeyUT	000462712900019
関連URL	isVersionOf https://doi.org/10.2334/josnusd.18-0038

Awareness of Clenching and Underweight are Risk Factors for Onset of Crowding in Young Adults: A Prospective 3-Year Cohort Study

フルテキストURL	ijerph16_5_00690.pdf
著者	Toyama, Naoki\| Ekuni, Daisuke\| Taniguchi-Tabata, Ayano\| Kataoka, Kota\| Yamane-Takeuchi, Mayu\| Fujimori, Kohei\| Kobayashi, Terumasa\| Fukuhara, Daiki\| Irie, Koichiro\| Azuma, Tetsuji\| Iwasaki, Yoshiaki\| Morita, Manabu\|
キーワード	bruxism cohort study malocclusion underweight young adults
発行日	2019-02-26
出版物タイトル	International Journal of Environmental Research and Public Health
巻	16巻
号	5号
出版者	MDPI
開始ページ	690
ISSN	1660-4601
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2019 by the authors
論文のバージョン	publisher
PubMed ID	30813621
DOI	10.3390/ijerph16050690
Web of Science KeyUT	000462664200015
関連URL	isVersionOf https://doi.org/10.3390/ijerph16050690

Effectiveness of Extending Treatment Duration in Therapy with Pegylated Interferon and Ribavirin for Genotype 2 Hepatitis C Virus Infection

JaLCDOI	10.18926/AMO/53560
フルテキストURL	69_4_237.pdf
著者	Nanba, Shintarou\| Ikeda, Fusao\| Fujioka, Shin-ichi\| Araki, Yasuyuki\| Takaguchi, Kouichi\| Hashimoto, Noriaki\| Seki, Hiroyuki\| Takaki, Akinobu\| Iwasaki, Yoshiaki\| Yamamoto, Kazuhide\|
抄録	The effectiveness of extending treatment duration as response guided therapy was previously reported for chronic hepatitis C (CHC) genotype 1, but is still controversial for genotype 2. The present study is a retrospective cohort study to investigate the effectiveness of extending treatment duration in therapy with pegylated interferon and ribavirin for patients with CHC genotype 2 by focusing on the timing at which patients obtained undetectable HCV RNA. A total of 306 patients who obtained undetectable HCV RNA by week 24 of treatment and completed 24 weeks of treatment were enrolled. Rapid virological response (RVR) to standard therapy was achieved by 122 patients (51ｵ), and 89ｵ of them obtained sustained virological response (SVR), while 69ｵ of non-RVR patients achieved SVR. Non-RVR patients with undetectable HCV RNA at week 8, and insufficient adherence＜80ｵ pegylated interferon and ribavirin during the first 24 weeks, significantly improved their SVR rate by extended therapy. Among patients receiving extended therapy, drug adherences did not differ between SVR and non-SVR patients, indicating that extending treatment duration might compensate for insufficient antiviral effects due to insufficient drug adherences. This finding might be useful in creating a guideline for extending treatment duration for patients with CHC genotype 2.
キーワード	hepatitis C virus interferon genotype 2 response-guided therapy
Amo Type	Original Article
発行日	2015-08
出版物タイトル	Acta Medica Okayama
巻	69巻
号	4号
出版者	Okayama University Medical School
開始ページ	237
終了ページ	244
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	English
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26289915
Web of Science KeyUT	000365519100007

Aberrant Expression of Keratin 7 in Hepatocytes as a Predictive Marker of Rapid Progression to Hepatic Failure in Asymptomatic Primary Biliary Cirrhosis

JaLCDOI	10.18926/AMO/53520
フルテキストURL	69_3_137.pdf
著者	Seki, Hiroyuki\| Ikeda, Fusao\| Nanba, Shintaro\| Moritou, Yuki\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Onishi, Hideki\| Miyake, Yasuhiro\| Takaki, Akinobu\| Nouso, Kazuhiro\| Iwasaki, Yoshiaki\| Nakamura, Minoru\| Yamamoto, Kazuhide\|
抄録	A predictive marker of the rapid progression to hepatic failure is desired for patients with asymptomatic primary biliary cirrhosis (aPBC). We performed a systematic cohort analysis of 101 patients diagnosed as having aPBC and the rapid progression to liver failure in some, by focusing on cholestasis. Cholestasis was assessed by aberrant keratin7 (K-7) expressions in the patientsʼ hepatocytes. Intralobular expressions of K-7 were found in 9 of the 101 patients. The grades of K-7 expression were significantly associated with the levels of alanine aminotransferase, alkaline phosphatase, and total bilirubin at the time of diagnosis, but not with bile duct loss or cholestasis. Stepwise logistic regression analysis revealed that high grades of K-7 expression correlated positively with high levels of total bilirubin. During the follow-up period, 8 patients developed jaundice, and the mean period until the development of jaundice was 5.2 years. The proportional hazards models for the risk of developing jaundice identified a high grade of aberrant K-7 expression in hepatocytes as the only significant risk factor. Aberrant K-7 expression in hepatocytes can be used as an additional marker to predict rapid progression to liver failure in patients with aPBC at the time of diagnosis.
キーワード	primary biliary cirrhosis keratin 7 hepatic failure
Amo Type	Original Article
発行日	2015-06
出版物タイトル	Acta Medica Okayama
巻	69巻
号	3号
出版者	Okayama University Medical School
開始ページ	137
終了ページ	144
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	English
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26101189
Web of Science KeyUT	000356903000002

Laparoscopic findings of reddish markings predict hepatocellular carcinoma in patients with hepatitis B virus-related liver disease

著者	Shoji, Bon\| Ikeda, Fusao\| Fujioka, Shin-ichi\| Kobashi, Haruhiko\| Yasunaka, Tetsuya\| Miyake, Yasuhiro\| Shiraha, Hidenori\| Takaki, Akinobu\| Nouso, Kazuhiro\| Iwasaki, Yoshiaki\| Yamamoto, Kazuhide\|
発行日	2010-11
出版物タイトル	Journal of Gastroenterology
巻	45巻
号	11号
資料タイプ	学術雑誌論文

The impact of patatin-like phospholipase domain-containing protein 3 polymorphism on hepatocellular carcinoma prognosis

著者	Takeuchi, Yasuto\| Ikeda, Fusao\| Moritou, Yuki\| Hagihara, Hiroaki\| Yasunaka, Tetsuya\| Kuwaki, Kenji\| Miyake, Yasuhiro\| Ohnishi, Hideki\| Nakamura, Shinichiro\| Shiraha, Hidenori\| Takaki, Akinobu\| Iwasaki, Yoshiaki\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
発行日	2013-03
出版物タイトル	Journal of Gastroenterology
巻	48巻
号	3号
資料タイプ	学術雑誌論文

Necessity for Reassessment of Patients with Serogroup 2 Hepatitis C Virus (HCV) and Undetectable Serum HCV RNA

著者	Moritou, Yuki\| Ikeda, Fusao\| Takeuchi, Yasuto\| Seki, Hiroyuki\| Nanba, Shintaro\| Iwasaki, Yoshiaki\| Yamamoto, Kazuhide\|
発行日	2014-02
出版物タイトル	Journal of Clinical Microbiology
巻	52巻
号	2号
資料タイプ	学術雑誌論文

Hepatitis C Virus-specific T-cell Response Correlates with Hepatitis Activity and Donor IL28B Genotype Early after Liver Transplantation

JaLCDOI	10.18926/AMO/52898
フルテキストURL	68_5_291.pdf
著者	Tsuzaki, Ryuichiro\| Takaki, Akinobu\| Yagi, Takahito\| Ikeda, Fusao\| Koike, Kazuko\| Iwasaki, Yoshiaki\| Shiraha, Hidenori\| Miyake, Yasuhiro\| Sadamori, Hiroshi\| Shinoura, Susumu\| Umeda, Yuzo\| Yoshida, Ryuichi\| Nobuoka, Daisuke\| Utsumi, Masashi\| Nakayama, Eiichi\| Fujiwara, Toshiyoshi\| Yamamoto, Kazuhide\|
抄録	It is not known how the immune system targets hepatitis C virus (HCV)-infected HLA-mismatched hepatocytes under immune-suppressed conditions after orthotopic liver transplantation (OLT). In addition, the relationship between the HCV-specific immune response and IL28B variants as predictors of HCV clearance has not been well-characterized. We determined the IL28B polymorphisms for 57 post-OLT HCV carriers, and we assessed the HCV-specific immune responses by measuring the peripheral blood mononuclear cell-derived HCV-specific interferon-gamma (IFN-γ) response using an enzyme-linked immunospot assay. At 1-3 years after OLT, patients with no active hepatitis showed higher total spots on the immunospot assay. At＞3 years after OLT, patients with resolved HCV showed higher levels of core, NS3, NS5A, and total spots compared to the chronic hepatitis patients. The IL28B major genotype in the donors correlated with higher spot counts for NS5A and NS5B proteins at 1-3 years after OLT. In the post-OLT setting, the HCV-specific immune response could be strongly induced in patients with no active hepatitis with an IL28B major donor or sustained virological response. Strong immune responses in the patients with no active hepatitis could only be maintained for 3 years and diminished later. It may be beneficial to administer IFN treatment starting 3 years after OLT, to induce the maximum immunological effect.
キーワード	interferon gamma ELISPOT assay single nucleotide polymorphisms dendritic cell CD4 T cell
Amo Type	Original Article
発行日	2014-10
出版物タイトル	Acta Medica Okayama
巻	68巻
号	5号
出版者	Okayama University Medical School
開始ページ	291
終了ページ	302
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	English
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25338486
Web of Science KeyUT	000343269300006
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/53129

Nursing Support Increases the Efficacy of Interferon Therapy in Patients with Chronic Hepatitis C

JaLCDOI	10.18926/AMO/52894
フルテキストURL	68_5_263.pdf
著者	Namba, Shihoko\| Miyake, Kayoko\| Ikeda, Fusao\| Hazama, Tomoko\| Hitobe, Yu\| Yamasaki, Noriko\| Shiraha, Hidenori\| Takaki, Akinobu\| Nouso, Kazuhiro\| Iwasaki, Yoshiaki\| Yamamoto, Kazuhide\|
抄録	Nursing support might help patients with chronic hepatitis C (CHC) remain in good mental and physical condition during interferon (IFN) therapy. However, the effects of nursing support have not been studied adequately in this context. This case-control study evaluated the effects of nursing support during IFN therapy. Twenty-four CHC patients who received pegylated IFN and ribavirin were enrolled. Nurses advised patients on the maintenance of their mental and physical condition at weekly visits, based on the results of written questionnaires. An additional 24 patients who received IFN therapy without nursing support and who were matched for age, sex, platelet count, viral serogroup and IFN regimen were selected with propensity score matching as controls. The patients with nursing support during IFN therapy achieved higher sustained virological responses (79%) than those without nursing support (58%). Adherence to the IFN and ribavirin regimens at 24 weeks of therapy were slightly higher in the patients with nursing support than those without it, but these differences were not statistically significant. Adherence to ribavirin after 24 weeks of therapy was significantly higher in those with nursing support than those without it (93% and 66%, p＝0.045). These results suggested that nursing support services could contribute to the virological responses of CHC patients by promoting drug-regimen adherence.
キーワード	chronic hepatitis C nursing support interferon therapy
Amo Type	Original Article
発行日	2014-10
出版物タイトル	Acta Medica Okayama
巻	68巻
号	5号
出版者	Okayama University Medical School
開始ページ	263
終了ページ	268
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	English
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25338482
Web of Science KeyUT	000343269300002

Effects of self-efficacy on oral health behaviours and gingival health in university students aged 18- or 19-years-old

著者	Mizutani, Shinsuke\| Ekuni, Daisuke\| Furuta, Michiko\| Tomofuji, Takaaki\| Irie, Koichiro\| Azuma, Tetsuji\| Kojima, Azusa\| Nagase, Jun\| Iwasaki, Yoshiaki\| Morita, Manabu\|
発行日	2012-09
出版物タイトル	Journal of Clinical Periodontology
巻	39巻
号	9号
資料タイプ	学術雑誌論文

Assessment of health-related quality of life and how it predicts the outcome of pegylated interferon and ribavirin therapy for chronic hepatitis C

著者	Matsushita, Hiroshi\| Ikeda, Fusao\| Iwasaki, Yoshiaki\| Seki, Hiroyuki\| Nanba, Shintaro\| Takeuchi, Yasuto\| Moritou, Yuki\| Yasunaka, Tetsuya\| Onishi, Hideki\| Miyake, Yasuhiro\| Takaki, Akinobu\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
発行日	2014-02
出版物タイトル	Journal of Gastroenterology and Hepatology
巻	29巻
号	2号
資料タイプ	学術雑誌論文

Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients

著者	Tatsukawa, Masashi\| Takaki, Akinobu\| Shiraha, Hidenori\| Koike, Kazuko\| Iwasaki, Yoshiaki\| Kobashi, Haruhiko\| Fujioka, Shin-Ichi\| Sakaguchi, Kohsaku\| Yamamoto, Kazuhide\|
発行日	2011-10-21
出版物タイトル	BMC Cancer
巻	11巻
資料タイプ	学術雑誌論文

Impact of Comorbid Hepatic Steatosis on Treatment of Chronic Hepatitis C in Japanese Patients and the Relationship with Genetic Polymorphism of IL28B, PNPLA3 and LDL Receptor

JaLCDOI	10.18926/AMO/52139
フルテキストURL	68_1_17.pdf
著者	Moritou, Yuki\| Ikeda, Fusao\| Iwasaki, Yoshiaki\| Baba, Nobuyuki\| Takaguchi, Kouichi\| Senoh, Tomonori\| Nagano, Takuya\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Ohnishi, Hideki\| Miyake, Yasuhiro\| Takaki, Akinobu\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
抄録	The impact of hepatic steatosis on interferon therapy for patients with chronic hepatitis C (CHC) has been associated with single-nucleotide polymorphisms (SNP) of IL28B, patatin-like phospholipase domain-containing protein 3 (PNPLA3), and low-density lipoprotein (LDL) receptor. Whether this holds true for Japanese patients, however, remains unresolved. The present study prospectively enrolled 226 Japanese patients with CHC, and investigated the impact of hepatic steatosis and its related SNPs, including rs8099917 of IL28B, rs738409 of PNPLA3, and rs14158 of LDL receptor, on outcomes of peg-interferon and ribavirin therapy. In multivariate logistic regression analysis, significant factors affecting the severity of hepatic steatosis were high body mass index and the minor alleles of IL28B SNP (p＝0.020 and 0.039, respectively). The risk alleles of PNPLA3 SNP also showed weak association (p＝0.059). Severe steatosis and the minor alleles of IL28B SNP were significantly associated with null or partial virological response in patients with HCV genotype 1, as were female gender, and low LDL cholesterol (p＝0.049, and ＜0.001, respectively). The SNP genotype of PNPLA3 and LDL receptor did not have a significant impact on therapeutic outcomes. With respect to the SNP sites examined, the SNP of PNPLA3 has a weak association with severe hepatic steatosis, but not with the outcome of interferon therapy.
キーワード	hepatic steatosis genetic polymorphism interferon HCV
Amo Type	Original Article
発行日	2014-02
出版物タイトル	Acta Medica Okayama
巻	68巻
号	1号
出版者	Okayama University Medical School
開始ページ	17
終了ページ	22
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	English
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	24553484
Web of Science KeyUT	000331592800003

岩崎 良章