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ID 61306
フルテキストURL
著者
Nakata, Eiji Department of Orthopedic Surgery, Okayama University Hospital
Sugihara, Shinsuke Department of Orthopedic Surgery, Shikoku Cancer Center
Sugawara, Yoshifumi Department of Radiology, Shikoku Cancer Center
Nakahara, Ryuichi Department of Orthopedic Surgery, Okayama University Hospital
Furumatsu, Takayuki Department of Orthopedic Surgery, Okayama University Hospital Kaken ID publons
Tetsunaga, Tomonori Department of Orthopedic Surgery, Okayama University Hospital ORCID Kaken ID
Kunisada, Toshiyuki Department of Orthopedic Surgery, Okayama University Hospital Kaken ID researchmap
Nakanishi, Kazuo Department of Orthopedic Surgery, Kawasaki Medical School Hospital
Ozaki, Toshifumi Department of Orthopedic Surgery, Okayama University Hospital, Kaken ID publons researchmap
抄録
Malignant spinal cord compression (MSCC) is a serious complication of cancers. The present study aimed to establish a multidisciplinary treatment system for urgent magnetic resonance imaging (MRI) and referral to orthopedists in order to prevent neurological deficits caused by MSCC. In the present study, the extent to which this system achieved early diagnosis and treatment and prevented MSCC‑caused neurological deficits was examined. The records from patients with neurological deficits caused by MSCC before (between April 2007 and March 2012; group A) and after (between April 2012 and March 2017; group B) the establishment of the multidisciplinary system at the Shikoku Cancer Center (Ehime, Japan) were retrospectively evaluated. The numbers of patients with neurological deficits were 38 and 7 in groups A and B, respectively. All patients received radiotherapy. The incidence of neurological deficits was 13.2 and 3.4% in groups A and B, respectively (P<0.001). The proportion of patients with improvement in the severity of neurological deficits was 5.3 and 28.6% in groups A and B, respectively (P<0.001). The interval between physicians' recognition of a neurological deficit and MRI and the start of treatment, the number of cases, and the severity of neurological deficits were evaluated in groups A and B. The median interval between recognition of a neurological deficit by physicians and MRI was 3 and 0 days in groups A and B, respectively (P<0.001). The median interval between physicians' recognition of a neurological deficit and the start of treatment was 3 and 0 days in groups A and B, respectively (P<0.001). By using a multidisciplinary treatment system, the incidence and severity of neurological deficits following treatment were significantly improved. Therefore, the multidisciplinary treatment system used in the present study may be useful for early diagnosis, treatment and prevention of MSCC in patients with bone metastases.
キーワード
bone metastasis
multidisciplinary treatment
skeletal-related event
malignant spinal cord compression
neurological deficit
発行日
2020-02-20
出版物タイトル
Oncology Letters
19巻
4号
出版者
Spandidos Publications
開始ページ
3137
終了ページ
3144
ISSN
1792-1074
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© Nakata et al.
論文のバージョン
publisher
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.3892/ol.2020.11415
ライセンス
https://creativecommons.org/licenses/by-nc-nd/4.0/