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ID 31591
JaLCDOI
フルテキストURL
著者
Ohnoshi, Taisuke Okayama University
Hiraki, Shunkichi Okayama Red-Cross Hospital
Fujii, Masafumi National Shikoku Cancer Center
Ueoka, Hiroshi Okayama University
Yonei, Toshiro National Okayama Hospital
Tamura, Makoto Okayama University
Moritaka, Tomonori Prefectural Medical Center of Ehime
Mima, Yuchi Okayama University
Horiguchi, Takashi Okayama University
Kiura, Katsuyuki Okayama University ORCID Kaken ID publons researchmap
Kamei, Haruhito Okayama University
Kodani, Tsuyoshi Okayama University
Hiraki, Yoshio Okayama University
Kimura, Ikuro Okayama University
抄録

We evaluated the long-term outcome of 148 patients with small cell lung cancer (SCLC) who had been entered into clinical trials of chemotherapy with or without thoracic and prophylactic cranial irradiation (PCI) between 1981 and 1987. Eighteen patients (12%) survived for 2 or more years. With a minimum follow-up of 4.5 years, 10 of the 18 patients who remained disease-free at 2 years are currently alive and free of SCLC. Seven of these 10 patients currently function as they did before diagnosis. However, three suffer from central nervous system changes of varying degrees in severity which appeared 2-3 years after PCI. Eight of the 18 patients who were disease-free at 2 years have died. Two died of isolated relapse in the brain at 3.6 and 4.2 years after initiation of chemotherapy. Five died of other malignancies while continuing their complete response to SCLC; two of non-small cell lung cancer, two of acute myelogenous leukemia, and one of hepatocellular carcinoma. Another patient died of an unrelated disease without any evidence of SCLC. A small but substantial proportion of patients who underwent intensive treatment will achieve long-term survival; however, these patients remain at higher risk for second cancers and late toxicities. Therefore, attention must be directed to defining the safest way to employ such treatment in the management of SCLC.

キーワード
small cell lung cancer
long-term survivors
late relapse
toxicities
complications
Amo Type
Article
発行日
1993-06
出版物タイトル
Acta Medica Okayama
47巻
3号
出版者
Okayama University Medical School
開始ページ
209
終了ページ
214
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT