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ID 52860
フルテキストURL
著者
Zou, Yu Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth
Wang, Da-Hong Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth
Sakano, Noriko Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gerontol Res
Sato, Yoshie Okayama Univ, Grad Sch Hlth Sci
Iwanaga, Suketaka Kyoto Univ, Fac Med, Dept Publ Hlth
Taketa, Kazuhisa Geriatr Hlth Serv Facil
Kubo, Masayuki Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth
Takemoto, Kei Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth
Masatomi, Chie Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth
Inoue, Kiyomi Kobe Tokiwa Univ, Fac Hlth Sci, Dept Nursing
Ogino, Keiki Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth
抄録
Retinol, alpha-tocopherol, and gamma-tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about circulatory levels in healthy individuals. The present cross-sectional study aimed at elucidating the relationship between these antioxidants and clinical biomarkers in 206 male (median age 41 years, range 23-67) employees from companies located in the Okayama Prefecture, Japan. Subjects younger than 40 years (n = 94) showed a positive association of the frequency of alcohol consumption with the circulating retinol (beta = 0.344, p = 0.001) and gamma-tocopherol levels (beta = 0.219, p = 0.041), and an inverse association of fast insulin with serum retinol (beta = -0.301, p = 0.009). In participants older than 40 years (n = 112) we found that an inverse association of HOMA-R with serum retinol (beta = -0.262, p = 0.021), a-tocopherol (beta = -0.236, p = 0.035), and gamma-tocopherol levels (beta = -0.224, p = 0.052); and cigarette smoking was inversely associated with the levels of serum a-tocopherol (beta = -0.286, p = 0.008) and gamma-tocopherol (beta = -0.229, p = 0.040). We further found negative relationships between serum ferritin and the retinol (beta = -0.211, p = 0.032) and a-tocopherol levels (beta = -0.223, p = 0.022) in men over 40 years of age. The present study suggests that the circulatory levels of antioxidant vitamins may modulate the action of insulin and that higher levels of iron might decrease the levels of antioxidant vitamins in the blood.
キーワード
serum retinol
serum alpha-tocopherol
serum gamma-tocopherol
HOMA-R
serum ferritin
smoking
alcohol consumption
発行日
2014-02
出版物タイトル
International Journal of Environmental Research and Public Health
11巻
2号
開始ページ
1647
終了ページ
1660
ISSN
1660-4601
資料タイプ
学術雑誌論文
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/52831
言語
English
著作権者
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
論文のバージョン
publisher
査読
有り
DOI
Web of Sience KeyUT