フルテキストURL | fulltext.pdf |
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著者 | Sada, Ken-Ei| Ohashi, Keiji| Asano, Yosuke| Hayashi, Keigo| Morishita, Michiko| Watanabe, Haruki| Matsumoto, Yoshinori| Fujimoto, Shouichi| Takasaki, Yoshinari| Yamagata, Kunihiro| Banno, Shogo| Dobashi, Hiroaki| Amano, Koichi| Harigai, Masayoshi| Arimura, Yoshihiro| Makino, Hirofumi| the Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis (JPVAS) and the Research Committee of Intractable Renal Disease of the Ministry of Health, Labour, and Welfare of Japan| |
キーワード | ANCA-associated vasculitis Chronic damage Elderly patients Glucocorticoids |
発行日 | 2020-10-12 |
出版物タイトル | Arthritis Research & Therapy |
巻 | 22巻 |
号 | 1号 |
出版者 | BMC |
開始ページ | 236 |
ISSN | 1478-6354 |
NCID | AA11830978 |
資料タイプ | 学術雑誌論文 |
言語 | English |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s). 2020 |
論文のバージョン | publisher |
PubMed ID | 33046139 |
DOI | 10.1186/s13075-020-02341-6 |
Web of Science KeyUT | 000582369300003 |
関連URL | isVersionOf https://doi.org/10.1186/s13075-020-02341-6 |
フルテキストURL | fulltext.pdf |
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著者 | Shikata, Kenichi| Haneda, Masakazu| Ninomiya, Toshiharu| Koya, Daisuke| Suzuki, Yoshiki| Suzuki, Daisuke| Ishida, Hitoshi| Akai, Hiroaki| Tomino, Yasuhiko| Uzu, Takashi| Nishimura, Motonobu| Maeda, Shiro| Ogawa, Daisuke| Miyamoto, Satoshi| Makino, Hirofumi| the Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT‐Japan) collaborative group| |
キーワード | Diabetic kidney disease Diabetic nephropathy Diabetic Nephropathy Remission and Regression Team Trial in Japan |
発行日 | 2020-08-08 |
出版物タイトル | Journal of Diabetes Investigation |
巻 | 12巻 |
号 | 2号 |
出版者 | Wiley |
開始ページ | 207 |
終了ページ | 216 |
ISSN | 2040-1116 |
NCID | AA12488319 |
資料タイプ | 学術雑誌論文 |
言語 | English |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2020 The Authors |
論文のバージョン | Publisher |
PubMed ID | 32597548 |
NAID | 120006880216 |
DOI | 10.1111/jdi.13339 |
Web of Science KeyUT | 000557091100001 |
関連URL | isVersionOf https://doi.org/10.1111/jdi.13339 |
タイトル(別表記) | The perception of chronic kidney disease in a general population in Okayama, Japan : 2015 |
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フルテキストURL | 129_101.pdf |
著者 | 内田 治仁| 杉山 斉| 宮崎 雅史| 和田 淳| 四方 賢一| 柏原 直樹| 槇野 博史| |
抄録 | Public education programs about chronic kidney disease (CKD) have been performed in Okayama, Japan for the past 10 years. The present study investigated the perception of CKD in a general population in Okayama. In October and November 2015, a questionnaire survey was distributed by 12 medical centers in five medical districts in Okayama prefecture. A total of 7,022 respondents who underwent their physical checkup at these centers answered the questionnaire. In response to a questionnaire item asking about the respondent's familiarity with the term "CKD," only 4% of the respondents answered "know it well" and 10% answered "unfamiliar." In contrast, in response to a questionnaire item asking about the respondent's familiarity with "chronic kidney disease," 27% answered "know it well" and 38% answered "unfamiliar." The leading avenue by which the respondents learned about CKD/chronic kidney disease was television, followed by newspapers, magazines, and a family doctor or nurse. The leading component which the respondents considered essential for the diagnosis of CKD/chronic kidney disease was proteinuria. A stratified analysis demonstrated a higher recognition of “CKD" or “chronic kidney disease" in the medical districts in northern Okayama prefecture compared to southern Okayama prefecture. These results indicated that the awareness of CKD in Okayama prefecture is still inadequate. Many people did not appear to realize that the term “CKD" represents "chronic kidney disease". Further continuous public education efforts are required to enlighten people about CKD/chronic kidney disease. |
キーワード | 慢性腎臓病 (chronic kidney disease) CKD 認知度 (perception) 岡山県 (Okayama) 医療圏別 (medical distinct) |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2017-08-01 |
巻 | 129巻 |
号 | 2号 |
開始ページ | 101 |
終了ページ | 105 |
ISSN | 0030-1558 |
関連URL | https://doi.org/10.4044/joma.129.101 |
言語 | Japanese |
著作権者 | Copyright (c) 2017 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma.129.101 |
NAID | 130006039371 |
タイトル(別表記) | Clinical Research Core Center and Okayama University |
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フルテキストURL | 129_45.pdf |
著者 | 槇野 博史| |
キーワード | オール岡山大学 臨床研究中核病院 橋渡し研究加速ネットワークプログラム事業 |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2017-04-03 |
巻 | 129巻 |
号 | 1号 |
開始ページ | 45 |
終了ページ | 49 |
ISSN | 0030-1558 |
言語 | Japanese |
著作権者 | Copyright (c) 2017 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma.129.45 |
NAID | 130005632070 |
フルテキストURL | Mod_Rheumatol_26_5_730.pdf |
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著者 | Sada, Ken-ei| Harigai, Masayoshi| Amano, Koichi| Atsumi, Tatsuya| Fujimoto, Shouichi| Yuzawa, Yukio| Takasaki, Yoshinari| Banno, Shogo| Sugihara, Takahiko| Kobayashi, Masaki| Usui, Joichi| Yamagata, Kunihiro| Homma, Sakae| Dobashi, Hiroaki| Tsuboi, Naotake| Ishizu, Akihiro| Sugiyama, Hitoshi| Okada, Yasunori| Arimura, Yoshihiro| Matsuo, Seiichi| Makino, Hirofumi| |
キーワード | Antineutrophil cytoplasmic antibody-associated vasculitis Eosinophilic granulomatosis with polyangiitis Granulomatosis with polyangiitis Inception cohort Microscopic polyangiitis |
備考 | This is an Accepted Manuscript of an article published by Taylor & Francis Group| |
発行日 | 2016-03-11 |
出版物タイトル | Modern Rheumatology |
巻 | 26巻 |
号 | 5号 |
出版者 | Taylor & Francis |
開始ページ | 730 |
終了ページ | 737 |
ISSN | 1439-7595 |
NCID | AA1157187X |
資料タイプ | 学術雑誌論文 |
言語 | English |
OAI-PMH Set | 岡山大学 |
著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
論文のバージョン | author |
PubMed ID | 26873424 |
DOI | 10.3109/14397595.2016.1140274 |
Web of Science KeyUT | 000393120600018 |
関連URL | https://doi.org/10.3109/14397595.2016.1140274 |
タイトル(別表記) | Advances in Diabetology, The 49th Annual Post Graduate Course |
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フルテキストURL | 127_167.pdf |
著者 | 槇野 博史| |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2015-08-03 |
巻 | 127巻 |
号 | 2号 |
開始ページ | 167 |
終了ページ | 168 |
ISSN | 0030-1558 |
関連URL | isVersionOf https://doi.org/10.4044/joma.127.167 |
言語 | Japanese |
著作権者 | Copyright (c) 2015 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma.127.167 |
NAID | 130005096244 |
著者 | Kitamura, Shinji| Sakurai, Hiroyuki| Makino, Hirofumi| |
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発行日 | 2015-03 |
出版物タイトル | Stem cells |
巻 | 33巻 |
号 | 3号 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/53117 |
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フルテキストURL | 69_1_1.pdf |
著者 | Watatani, Hiroyuki| Yamasaki, Hiroko| Maeshima, Yohei| Nasu, Tatsuyo| Hinamoto, Norikazu| Ujike, Haruyo| Sugiyama, Hitoshi| Sakai, Yoshiki| Tanabe, Katsuyuki| Makino, Hirofumi| |
抄録 | Diabetic nephropathy is the most common pathological disorder predisposing patients to end-stage renal disease. Considering the increasing prevalence of type 2 diabetes mellitus worldwide, novel therapeutic approaches are urgently needed. ONO-1301 is a novel sustained-release prostacyclin analog that inhibits thromboxane A2 synthase. Here we examined the therapeutic effects of the intermittent administration of slow-release ONO-1301 (SR-ONO) on diabetic nephropathy in obese type 2 diabetes mice, as well as its direct effects on mesangial cells. The subcutaneous injection of SR-ONO (3mg/kg) every 3 wks did not affect the obesity or hyperglycemia in the db/db obese mice used as a model of type 2 diabetes, but it significantly ameliorated their albuminuria, glomerular hypertrophy, glomerular accumulation of type IV collagen, and monocyte/macrophage infiltration, and also the increase of TGF-β1, α-smooth muscle actin (α-SMA) and MCP-1 compared to vehicle treatment. In cultured mouse mesangial cells, ONO-1301 concentration-dependently suppressed the increases in TGF-β, type IV collagen, α-SMA, MCP-1 and fibronectin induced by high ambient glucose, at least partly through prostacyclin (PGI2) receptor-mediated signaling. Taken together, these results suggest the potential therapeutic efficacy of the intermittent administration of SR-ONO against type 2 diabetic nephropathy, possibly through protective effects on mesangial cells. |
キーワード | prostacyclin ONO-1301 diabetic nephropathy TGF-β1 diabetes mellitus |
Amo Type | Original Article |
発行日 | 2015-02 |
出版物タイトル | Acta Medica Okayama |
巻 | 69巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 1 |
終了ページ | 15 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | English |
著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 25703166 |
Web of Science KeyUT | 000349740300001 |
関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/53128 |
著者 | Katayama, Akihiro| Nakatsuka, Atsuko| Eguchi, Jun| Murakami, Kazutoshi| Teshigawara, Sanae| Kanzaki, Motoko| Nunoue, Tomokazu| Hida, Kazuyuki| Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Takaki, Akinobu| Yamamoto, Kazuhide| Kiyonari, Hiroshi| Makino, Hirofumi| Wada, Jun| |
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発行日 | 2015 |
出版物タイトル | Scientific reports |
巻 | 5巻 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/52789 |
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フルテキストURL | 68_4_235.pdf |
著者 | Ono, Tetsuichiro| Shikata, Kenichi| Obika, Mikako| Miyatake, Nobuyuki| Kodera, Ryo| Hirota, Daisyo| Wada, Jun| Kataoka, Hitomi| Ogawa, Daisuke| Makino, Hirofumi| |
抄録 | The aim of this study was to clarify the factors associated with the remission and/or regression of microalbuminuria in Japanese patients with type 2 diabetes mellitus. We retrospectively analyzed the data of 130 patients with type 2 diabetes mellitus with microalbuminuria for 2-6 years (3.39±1.31 years). Remission was defined as improving from microalbuminuria to normoalbuminuria using the albumin/creatinine ratio (ACR), and regression of microalbuminuria was defined as a decrease in ACR of 50% or more from baseline. Progression of microalbuminuria was defined as progressing from microalbuminuria to overt proteinuria during the follow-up period. Among 130 patients with type 2 diabetes mellitus with microalbuminuria, 57 and 13 patients were defined as having remission and regression, respectively, while 26 patients progressed to overt proteinuria. Sex (female), higher HDL cholesterol and lower HbA1c were determinant factors associated with remission/regression of microalbuminuria by logistic regression analysis. Lower systolic blood pressure (SBP) was also correlated with remission/regression, but not at a significant level. These results suggest that proper control of blood glucose, BP and lipid profiles may be associated with remission and/or regression of type 2 diabetes mellitus with microalbuminuria in clinical practice. |
キーワード | microalbuminuria type 2 diabetes mellitus remission regression |
Amo Type | Original Article |
発行日 | 2014-08 |
出版物タイトル | Acta Medica Okayama |
巻 | 68巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 235 |
終了ページ | 241 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | English |
著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 25145409 |
Web of Science KeyUT | 000340687500005 |
関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52828 |
JaLCDOI | 10.18926/AMO/52788 |
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フルテキストURL | 68_4_219.pdf |
著者 | Hinamoto, Norikazu| Maeshima, Yohei| Saito, Daisuke| Yamasaki, Hiroko| Tanabe, Katsuyuki| Nasu, Tatsuyo| Watatani, Hiroyuki| Ujike, Haruyo| Kinomura, Masaru| Sugiyama, Hitoshi| Sonoda, Hikaru| Kanomata, Naoki| Sato, Yasufumi| Makino, Hirofumi| |
抄録 | Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r=0.48, p=0.001) or cortex (r=0.64, p<0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r=0.34, p=0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r=0.44, p=0.01) or medulla (r=0.63, p=0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2. |
キーワード | chronic kidney disease inflammation Vasohibin-1 VEGF-A VEGFR-2 |
Amo Type | Original Article |
発行日 | 2014-08 |
出版物タイトル | Acta Medica Okayama |
巻 | 68巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 219 |
終了ページ | 233 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | English |
著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 25145408 |
Web of Science KeyUT | 000340687500004 |
関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52824 |
著者 | Watanabe, Mayu| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Higuchi, Chigusa| Katayama, Akihiro| Teshigawara, Sanae| Eguchi, Jun| Ogawa, Daisuke| Watanabe, Eijiro| Wada, Jun| Makino, Hirofumi| |
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発行日 | 2014-05-25 |
出版物タイトル | PLOS ONE |
巻 | 9巻 |
号 | 3号 |
資料タイプ | 学術雑誌論文 |
著者 | Tsuji, Kenji| Kitamura, Shinji| Makino, Hirofumi| |
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発行日 | 2014-04-25 |
出版物タイトル | Biochemical and Biophysical Research Communications |
巻 | 447巻 |
号 | 1号 |
資料タイプ | 学術雑誌論文 |
タイトル(別表記) | Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophages |
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フルテキストURL | 126_1.pdf |
著者 | 宮本 聡| 四方 賢一| 宮坂 京子| 岡田 震一| 佐々木 基史| 小寺 亮| 廣田 大昌| 梶谷 展生| 高塚 哲全| 片岡 仁美| 西下 伸吾| 堀口 千景| 船越 顕博| 西森 久和| 内田 治仁| 小川 大輔| 槇野 博史| |
キーワード | cholecystokinin 糖尿病性腎症 抗炎症作用 腎保護効果 |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2014-04-01 |
巻 | 126巻 |
号 | 1号 |
開始ページ | 1 |
終了ページ | 6 |
ISSN | 0030-1558 |
関連URL | http://www.okayama-u.ac.jp/user/oma/ |
言語 | Japanese |
著作権者 | Copyright (c) 2014 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma.126.1 |
JaLCDOI | 10.18926/AMO/52143 |
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フルテキストURL | 68_1_43.pdf |
著者 | Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki| |
抄録 | The link between lifestyle modification and changes in both proteinuria and estimated glomerular filtration rates (eGFRs) was evaluated in Japanese subjects with proteinuria who were not taking medications. We used data from 51 men (35.8±10.0 years) and 74 women (38.0±11.0 years) with proteinuria at baseline and a 1-year follow up. eGFR was defined by a new equation developed specifically for Japanese subjects. Subjects were given advice for dietary and lifestyle improvement at the initial appointment. At the 1-year follow up, eGFR was increased in both sexes, but not at significant levels. (men:p=0.7709, women:p=0.2180). Proteinuria was also improved in many subjects. A decrease in proteinuria may be associated with improving eGFR in Japanese. |
キーワード | proteinuria estimated glomerular filtration rate (eGFR) lifestyle modification |
Amo Type | Short Communication |
発行日 | 2014-02 |
出版物タイトル | Acta Medica Okayama |
巻 | 68巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 43 |
終了ページ | 46 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | English |
著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 24553488 |
Web of Science KeyUT | 000331592800007 |
JaLCDOI | 10.18926/AMO/52138 |
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フルテキストURL | 68_1_7.pdf |
著者 | Horimoto, Naoya| Kitamura, Shinji| Tsuji, Kenji| Makino, Hirofumi| |
抄録 | Immunosuppressive agents are generally administered to treat kidney diseases. However, it is unclear whether renal stem/progenitor cells are directly affected by the immunosuppressive agents. We used normal rat kidney cells, ureteric bud cells and rat kidney stem/progenitor cells in this study. Mizoribine (MZR), cyclophosphamide (CPA) and cyclosporine (CyA) were added to the culture media of these cells. We evaluated the effects of these immunosuppressive agents on cell proliferation using an electrical cell-substrate impedance sensing system (ECIS) and their effects on the process of renal regeneration using the ischemia-reperfusion (I/R) injury rat model. The ECIS data showed that proliferation of each of the 3 types of cells was significantly suppressed by MZR. MZR treatment enhanced renal tubular injury in ischemia-reperfusion (I/R) injured rats, and significantly decreased levels of M-phase cells and Nestin-positive cells. These results suggested that MZR inhibits the cell cycle of renal stem/progenitor cells;thus, physicians should take note that MZR might affect not only inflammation but also renal regeneration. |
キーワード | cell biology immunosuppression stem cells |
Amo Type | Original Article |
発行日 | 2014-02 |
出版物タイトル | Acta Medica Okayama |
巻 | 68巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 7 |
終了ページ | 15 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | English |
著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 24553483 |
Web of Science KeyUT | 000331592800002 |
関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52247 |
著者 | Ogawa, Daisuke| Eguchi, Jun| Wada, Jun| Terami, Naoto| Hatanaka, Takashi| Tachibana, Hiromi| Nakatsuka, Atsuko| Sato Horiguchi, Chikage| Nishii, Naoko| Makino, Hirofumi| |
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発行日 | 2014-01-22 |
出版物タイトル | PLOS ONE |
巻 | 9巻 |
号 | 1号 |
資料タイプ | 学術雑誌論文 |
著者 | Nakayama, Kazunori| Nakao, Kazushi| Takatori, Yuji| Inoue, Junko| Kojo, Shoichirou| Akagi, Shigeru| Fukushima, Masaki| Wada, Jun| Makino, Hirofumi| |
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発行日 | 2013-12-18 |
出版物タイトル | International Journal of Nephrology and Renovascular Disease |
巻 | 7巻 |
資料タイプ | 学術雑誌論文 |
著者 | Terasaka, Tomohiro| Otsuka, Fumio| Tsukamoto, Naoko| Nakamura, Eri| Inagaki, Kenichi| Toma, Kishio| Ogura-Ochi, Kanako| Glidewell-Kenney, Christine| Lawson, Mark A.| Makino, Hirofumi| |
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発行日 | 2013-12-05 |
出版物タイトル | Molecular and Cellular Endocrinology |
巻 | 381巻 |
号 | 1-2号 |
資料タイプ | 学術雑誌論文 |
著者 | Terami, Takahiro| Wada, Jun| Inoue, Kentaro| Nakatsuka, Atsuko| Ogawa, Daisuke| Teshigawara, Sanae| Murakami, Kazutoshi| Katayama, Akihiro| Eguchi, Jun| Makino, Hirofumi| |
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発行日 | 2013-10-22 |
出版物タイトル | International Journal of Nephrology and Renovascular Disease |
巻 | 6巻 |
資料タイプ | 学術雑誌論文 |