| JaLCDOI | 10.18926/AMO/48562 |
|---|---|
| フルテキストURL | 66_3_231.pdf |
| 著者 | Takahashi, Kingo| Hayashi, Masamichi| Fujii, Toshihiro| Kawamura, Kenji| Ozaki, Toshifumi| |
| 抄録 | The objective of early rehabilitation after anterior cruciate ligament (ACL) reconstruction is to increase the muscle strength of the lower extremities. Closed kinetic chain (CKC) exercise induces co-contraction of the agonist and antagonist muscles. The purpose of this study was to compare the postoperative muscle strength/mass of subjects who performed our new CKC exercise (new rehabilitation group:group N) from week 4, and subjects who received traditional rehabilitation alone (traditional rehabilitation group:group T). The subjects stood on the device and maintained balance. Then, low-frequency stimulation waves were applied to 2 points each in the anterior and posterior region of the injured thigh 3 times a week for 3 months. Measurement of muscle strength was performed 4 times (before the start, and then once a month). Muscle mass was evaluated in CT images of the extensor and flexor muscles of 10 knees (10 subjects) in each group. The injured legs of group N showed significant improvement after one month compared to group T. The cross-sectional area of the extensor muscles of the injured legs tended to a show a greater increase at 3 months in group N. This rehabilitation method makes it possible to contract fast-twitch muscles, which may be a useful for improving extensor muscle strength after ACL reconstruction. |
| キーワード | anterior cruciate ligament reconstruction closed kinetic chain electrical muscle stimulation standing-shaking-board exercise |
| Amo Type | Original Article |
| 発行日 | 2012-06 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 66巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 231 |
| 終了ページ | 237 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22729103 |
| Web of Science KeyUT | 000305669700006 |
| JaLCDOI | 10.18926/AMO/49255 |
|---|---|
| フルテキストURL | 67_1_35.pdf |
| 著者 | Watanabe, Masutaka| Arita, Seizaburo| Hashizume, Hiroyuki| Honda, Mitsugi| Nishida, Keiichiro| Ozaki, Toshifumi| |
| 抄録 | The purpose of this study was to quantitatively evaluate Akahori's preoperative classification of cubital tunnel syndrome. We analyzed the results for 57 elbows that were treated by a simple decompression procedure from 1997 to 2004. The relationship between each item of Akahori's preoperative classification and clinical stage was investigated based on the parameter distribution. We evaluated Akahori's classification system using multiple regression analysis, and investigated the association between the stage and treatment results. The usefulness of the regression equation was evaluated by analysis of variance of the expected and observed scores. In the parameter distribution, each item of Akahori's classification was mostly associated with the stage, but it was difficult to judge the severity of palsy. In the mathematical evaluation, the most effective item in determining the stage was sensory conduction velocity. It was demonstrated that the established regression equation was highly reliable (R＝0.922). Akahori's preoperative classification can also be used in postoperative classification, and this classification was correlated with postoperative prognosis. Our results indicate that Akahori's preoperative classification is a suitable system. It is reliable, reproducible and well-correlated with the postoperative prognosis. In addition, the established prediction formula is useful to reduce the diagnostic complexity of Akahori's classification. |
| キーワード | cubital tunnel syndrome ulnar nerve Akahoriʼs classification multiple regression analysis |
| Amo Type | Original Article |
| 発行日 | 2013-02 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 67巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 35 |
| 終了ページ | 44 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23439507 |
| Web of Science KeyUT | 000316829900005 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/50647 |
| JaLCDOI | 10.18926/AMO/55439 |
|---|---|
| フルテキストURL | 71_5_413.pdf |
| 著者 | Furumatsu, Takayuki| Kodama, Yuya| Kamatsuki, Yusuke| Hino, Tomohito| Ozaki, Toshifumi| |
| 抄録 | Extrusion of the medial meniscus (MM) is associated with knee joint pain in osteoarthritic knees. The relationships among MM radial/oblique tears, MM extrusion (MME), and the effect of arthroscopic meniscal repair are not established. Here we evaluated the effects of arthroscopic all-inside MM repair on MME and the clinical outcomes in patients with radially oriented MM tears and mildly osteoarthritic knees. Twenty patients with a symptomatic radial or oblique tear of the MM posterior segment, MME ≥2.5 mm, and mildly osteoarthritic knees were treated using FasT-Fix 360 All-inside Meniscal Suture devices. We used magnetic resonance imaging (MRI) to measure the patients’ MM body width (MMBW), absolute MME, and relative MME. The Japanese Knee Injury and Osteoarthritis Outcome Score, Lysholm, Tegner, IKDC Subjective Knee Evaluation, and Visual Analogue Scale scores were obtained. Arthroscopic all-inside MM repair prevented increases of absolute and relative MME. The preoperative and 3- and 12-month MRI-based MMBW values were similar. Over a 24-month follow-up after the MM repairs, the clinical scores showed significant improvements. Our results suggest that all-inside meniscal repairs would be useful in preventing the progression of MME in patients suffering from symptomatic MM radial/oblique tears associated with mildly osteoarthritic knees. |
| キーワード | medial meniscus radial/oblique tear meniscal repair meniscal extrusion osteoarthritic knee |
| Amo Type | Original Article |
| 発行日 | 2017-10 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 71巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 413 |
| 終了ページ | 418 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29042699 |
| 著者 | Kikuchi, Takeshi| Kubota, Satoshi| Asaumi, Koji| Kawaki, Harumi| Nishida, Takashi| Kawata, Kazumi| Mitani, Shigeru| Tabata, Yasuhiko| Ozaki, Toshifumi| Takigawa, Masaharu| |
|---|---|
| 発行日 | 2008-06 |
| 出版物タイトル | Tissue Engineering Part A |
| 巻 | 14巻 |
| 号 | 6号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Yoneda, Yasushi| Ito, Sachio| Kunisada, Toshiyuki| Morimoto, Yuki| Kanzaki, Hirotaka| Yoshida, Aki| Shimizu, Kenji| Ozaki, Toshifumi| Ouchida, Mamoru| |
|---|---|
| 発行日 | 2013-10-09 |
| 出版物タイトル | PLoS ONE |
| 巻 | 8巻 |
| 号 | 10号 |
| 資料タイプ | 学術雑誌論文 |
| フルテキストURL | CORR477_8_1892.pdf |
|---|---|
| 著者 | Kunisada, Toshiyuki| Fujiwara, Tomohiro| Hasei, Joe| Nakata, Eiji| Senda, Masuo| Ozaki, Toshifumi| |
| 発行日 | 2019-08 |
| 出版物タイトル | Clinical Orthopaedics and Related Research |
| 巻 | 477巻 |
| 号 | 8号 |
| 出版者 | Lippincott, Williams & Wilkins |
| 開始ページ | 1892 |
| 終了ページ | 1901 |
| ISSN | 0009-921X |
| NCID | AA00607942 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 30985613 |
| DOI | 10.1097/CORR.0000000000000764 |
| Web of Science KeyUT | 000509664400024 |
| 関連URL | isVersionOf https://doi.org/10.1097/CORR.0000000000000764 |
| フルテキストURL | fulltext.pdf Suppl. Info.pdf Suppl. Tables.xlsx |
|---|---|
| 著者 | Morita, Takuya| Fujiwara, Tomohiro| Yoshida, Aki| Uotani, Koji| Kiyono, Masahiro| Yokoo, Suguru| Hasei, Joe| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| キーワード | Sarcoma Translational research |
| 発行日 | 2020-06-10 |
| 出版物タイトル | Scientific Reports |
| 巻 | 10巻 |
| 号 | 1号 |
| 出版者 | Nature |
| 開始ページ | 9414 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2020 |
| 論文のバージョン | publisher |
| PubMed ID | 32523124 |
| DOI | 10.1038/s41598-020-66120-8 |
| Web of Science KeyUT | 000560478900030 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-020-66120-8 |
| JaLCDOI | 10.18926/AMO/30721 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Inoue, Atsushi| Asaumi, Koji| Endo, Hirosuke| Fujiwara, Kazuo| Mitani, Shigeru| Ozaki, Toshifumi| |
| 抄録 | The present retrospective study assessed radiographs to determine socket wear in total hip arthroplasty (THA) with 22-mm zirconia or COP (Cobalt-Chrome alloy rich in Cobalt and Phosphorous) heads, and in cemented stems at more than 10 years after operation. Sockets of ultra high molecular weight polyethylene were used in each of two THA groups (13 hips each) in a clinical trial in our hospital between 1989 and 1990. Three observers carried out masked assessments of the radiographs. Upon fi nal examination, there was no remarkable loosening in the zirconia or COP group, and no case had required revision surgery as of 2005. There was a statistically signifi cant diff erence between the 2 groups in average annual linear wear, at 0.093 mm/year and 0.046 mm/year in the zirconia and COP groups, respectively. Volume wear and average annual volume wear were also signifi cantly greater in the zirconia group despite its superior mechanical strength and toughness in vitro. Our present fi ndings do not confi rm early expectations of lower wear in long-term results of 22-mm zirconia femoral heads used in THA. |
| キーワード | total hip arthroplasty zirconia head COP head polyethylene wear |
| Amo Type | Original Article |
| 発行日 | 2006-12 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 60巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 311 |
| 終了ページ | 318 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17189974 |
| Web of Science KeyUT | 000243019000002 |
| JaLCDOI | 10.18926/AMO/52008 |
|---|---|
| フルテキストURL | 67_6_351.pdf |
| 著者 | Yokoyama, Yusuke| Abe, Nobuhiro| Fujiwara, Kazuo| Suzuki, Masahiko| Nakajima, Yoshikazu| Sugita, Naohiko| Mitsuishi, Mamoru| Nakashima, Yoshio| Ozaki, Toshifumi| |
| 抄録 | A computer-assisted navigation system to be used for total knee arthroplasties (TKAs) was reported to improve the accuracy of bone resection and result in precise implant placement, but the concomitant surgical invasion and time consumption are clinical problems. We developed a computed tomography (CT)-based navigation system (NNS) to be used for minimally invasive TKA. It requires only the reference points from a small limited area of the medial femoral condyle and proximal tibia through a skin incision to obtain optical images. Here we evaluated the usefulness and accuracy of the NNS in comparison with the commercially available BrainLAB image-free navigation system (BLS). In a clinical experiment, the registration times obtained with the NNS tended to be shorter than those obtained with the BLS, but not significantly so. The NNS group tended to be in the extended position in the sagittal plane of the distal femur within 3 degrees, and the BLS group showed rather flexed deviation in the sagittal plane of the anterior femur. |
| キーワード | total knee arthroplasty navigation system minimally invasive surgery |
| Amo Type | Original Article |
| 発行日 | 2013-12 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 67巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 351 |
| 終了ページ | 358 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 24356719 |
| Web of Science KeyUT | 000328915700003 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52515 |
| 著者 | 田中 雅人| 杉本 佳久| 三澤 治夫| 高畑 智宏| 尾﨑 敏文| |
|---|---|
| 発行日 | 2010-04-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/30758 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Tanaka, Masato| Nakahara, Shinnosuke| Ito, Yauo| Nakanishi, Kazuo| Sugimoto, Yoshihisa| Ikuma, Hisanori| Ozaki, Toshifumi| |
| 抄録 | <p>The purpose of this study was to investigate the surgical outcomes and to determine indicators of the necessity of surgical intervention. Twelve consecutive patients harboring symptomatic sacral perineural cysts were treated between 1995 and 2003. All patients were assessed for neurological deficits and pain by neurological examination. Magnetic resonance of imaging, computerized tomography, and myelography were performed to detect signs of delayed filling of the cysts. We performed a release of the valve and imbrication of the sacral cysts with laminectomies in 8 cases or recapping laminectomies in 4 cases. After surgery, symptoms improved in 10 (83%) of 12 patients, with an average follow-up of 27 months. Ten patients had sacral perineural cysts with signs of positive filling defect. Two (17%) of 12 patients experienced no significant improvement. In one of these patients, the filling defect was negative. In conclusion, a positive filling defect may become an indicator of good treatment outcomes.</p> |
| キーワード | Tarlov cyst sacral perineural cyst meningeal cyst meningeal diverticulum sacral radiculopathy |
| Amo Type | Article |
| 発行日 | 2006-02 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 60巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 65 |
| 終了ページ | 70 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 16508691 |
| Web of Science KeyUT | 000235538900008 |
| JaLCDOI | 10.18926/AMO/31823 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Tanaka, Masato| Nakanishi, Kazuo| Sugimoto, Yoshihisa| Misawa, Haruo| Takigawa, Tomoyuki| Nishida, Keiichiro| Ozaki, Toshifumi| |
| 抄録 | <p>Scoliosis is a common clinical manifestation of Rett syndrome, a neurodevelopmental disorder that almost exclusively affects females. The spinal curve in patients with Rett syndrome is typically a long C curve of a neuromuscular type. As the onset of the scoliosis is very early and shows rapid progression, early surgical intervention has been recommended to prevent a life-threatening collapsing spine syndrome. However, there are high perioperative risks in Rett syndrome patients who undergo spinal surgery, such as neurological compromise and respiratory dysfunction due to rigid spinal curve. We herein report the surgical result of treating severe rapid progressive thoracic scoliosis in a 16-year-old girl with Rett syndrome. Posterior segmental pedicle screw fixation was performed from T1 to L3 using a computer-assisted technique. Post-operative radiography demonstrated a good correction of the curve in both the sagittal and coronal alignment. There were no postoperative complications such as neurological compromise. The patient had maintained satisfactory spinal balance as of the 3-year follow-up examination.</p> |
| キーワード | Rett syndrome scoliosis computer navigation-assisted surgery segmental pedicle screw fixation |
| Amo Type | Case Report |
| 発行日 | 2009-12 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 63巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 373 |
| 終了ページ | 377 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20035294 |
| Web of Science KeyUT | 000273145900009 |
| JaLCDOI | 10.18926/AMO/31849 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Tanaka, Masato| Nakahara, Shinnosuke| Ito, Yasuo| Kunisada, Toshiyuki| Misawa, Haruo| Koshimune, Koichiro| Ozaki, Toshifumi| |
| 抄録 | <p>Surgical treatment of metastatic spinal cord compression is controversial. The purpose of this study was to investigate the effectiveness of our current surgical treatments and the use of spinal instrumentation. In this retrospective study covering the years between 1990 and 2006, 100 patients with spinal metastases which were secondary to various cancers underwent posterior and/or anterior decompression with spinal stabilization for the purposes of reduction of pain, and/or to help correct or improve neurological deficits. The group was made up of 60 men and 40 women whose ages ranged from 16 to 83 years (average of 60 years), and the average follow-up period was 14 months. The effect of treatment upon pain relief and neural deficits was assessed, and the cumulative survival rate was calculated by the Kaplan-Meier method. The average surgical time was 185min. This was calculated based on the following times, listed here with the surgery type:178min for posterior surgery;245min for anterior surgery;465 min for combined surgery;and 475min for total en bloc spondylectomy. Average blood loss during surgery was 1,630 ml for posterior surgery, 1,760 ml for anterior surgery, 1,930 ml for combined surgery, and 3,640 ml for total en bloc spondylectomy. Preoperative pain and paralysis were improved by 88% and 53%, respectively. In regards to surgical complications, postoperative epidural hematoma was observed in 2 patients, and instrumentation-related infection was observed in 1. Only 2 patients died within 2 months of surgery. In conclusion, posterior and/or anterior decompression with spinal stabilization is a safe and effective treatment for patients with spinal metastases, and can improve their quality of life.</p> |
| キーワード | spinal metastasis spinal surgery instrumentation |
| Amo Type | Original Article |
| 発行日 | 2009-06 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 63巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 145 |
| 終了ページ | 150 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 19571901 |
| Web of Science KeyUT | 000267388200004 |
| JaLCDOI | 10.18926/AMO/32889 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Nakanishi, Kazuo| Tanaka, Masato| Sugimoto, Yoshihisa| Ozaki, Toshifumi| |
| 抄録 | <p>We performed fixation using laminar screws in 2 patients in whom lateral mass screws, pedicle screws or transarticular screws could not be inserted. One was a 56-year-old woman who had anterior atlantoaxial subluxation (AAS). When a guide wire was inserted using an imaging guide, the hole bled massively. We thought the re-insertion of a guide wire or screw would thus increase the risk of vascular injury, so we used laminar screws. The other case was an 18-year-old man who had a hangman fracture. Preoperative magnetic resonance angiography showed occlusion of the left vertebral artery. A laminar screw was inserted into the patent side (i.e., the right side of C2). Cervical pedicle screws are the most biomechanically stable screws. However, their use carries a high risk of neurovascular complications during screw insertion, because the cervical pedicle is small and is adjacent laterally to the vertebral artery, medially to the spinal cord, and vertically to the nerve roots. Lateral mass screws are also reported to involve a risk of neurovascular injuries. The laminar screw method was thus thought to be useful, since arterial injuries could thus be avoided and it could also be used as a salvage modality for the previous misinsertion.</p> |
| キーワード | laminar screw neurovascular complications lateral mass screw pedicle screw transarticular |
| Amo Type | Case Report |
| 発行日 | 2007-04 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 61巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 115 |
| 終了ページ | 119 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17471313 |
| Web of Science KeyUT | 000245875600010 |
| JaLCDOI | 10.18926/AMO/46634 |
|---|---|
| フルテキストURL | 65_3_211.pdf |
| 著者 | Nakanishi, Kazuo| Yamane, Kentarou| Tanaka, Masato| Misawa, Haruo| Saiga, Kenta| Ozaki, Toshifumi| |
| 抄録 | Here we report a case of surgery for kyphosis of the thoracolumbar spine in an elderly patient, in whom surgery was performed because the patient had developed intractable digestive symptoms. The case was that of a 76-year-old female with complaints of back pain and dysphagia. When videofluoroscopic examination (VF) of swallowing was performed in the cardia of the stomach, images that indicated stagnation and the reflux of food were observed. It was easier for the patient to swallow food in the extension position. We performed corrective fusion of the posterior spine. After the surgery, the kyphosis angle was improved to 27°, the patient's back pain was alleviated, and it became easier for the patient to swallow food. VF also showed that the patient's difficulties with the passage of food had improved. We believe that surgery is a good treatment option for cases of kyphosis with digestive symptoms and deteriorating activities of daily living (ADL), even in the absence of pain and paralysis. VF is also useful for performing evaluations before and after surgery. |
| キーワード | kyphosis dysphagia videofluoroscopic examination of swallowing (VF) fusion |
| Amo Type | Case Report |
| 発行日 | 2011-06 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 65巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 211 |
| 終了ページ | 214 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 21709720 |
| Web of Science KeyUT | 000292017500009 |
| JaLCDOI | 10.18926/AMO/47262 |
|---|---|
| フルテキストURL | 65_6_369.pdf |
| 著者 | Terada, Chuji| Yoshida, Aki| Nasu, Yoshihisa| Mori, Shuji| Tomono, Yasuko| Tanaka, Masato| Takahashi, Hideo K.| Nishibori, Masahiro| Ozaki, Toshifumi| Nishida, Keiichiro| |
| 抄録 | We investigated the expression and localization of high-mobility group box chromosomal protein-1 (HMGB-1) in human osteoarthritic (OA) cartilage in relation to the histopathological grade of cartilage destruction, and examined the role of HMGB-1 in the regulation of proinflammatory cytokine expression in chondrocytes. An immunohistochemical study demonstrated that total HMGB-1-positive cell ratios increase as the Osteoarthritis Research Society International (OARSI) histological grade increased. The population of cytoplasmic HMGB-1-positive chondrocytes was especially increased in the deep layers of higher-grade cartilage. The ratios and localization of receptors for advanced glycation end products (RAGE) expression by chondrocytes in Grade 2, 3, and 4 were significantly higher than those in Grade 1. In vitro stimulation with IL-1β, but not TNFα, significantly upregulated the expression of HMGB-1 mRNA by human OA chondrocytes. Both IL-1β and TNFα promoted the translocation of HMGB-1 from nuclei to cytoplasm. IL-1β and TNFα secretions were stimulated at higher levels of HMGB-1. The results of our study suggest the involvement of HMGB-1 in the pathogenesis of cartilage destruction in OA. |
| キーワード | HMGB-1 RAGE chondrocyte osteoarthritis cartilage |
| Amo Type | Original Article |
| 発行日 | 2011-12 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 65巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 369 |
| 終了ページ | 377 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22189477 |
| Web of Science KeyUT | 000298516900003 |
| 著者 | Okada, Yoshiki| Abe, Nobuhiro| Hisamori, Noriyuki| Kaneeda, Toshiaki| Moriyama, Shigeaki| Ohmori, Hitoshi| Mizutani, Masayoshi| Yanai, Hiroyuki| Nakashima, Yoshio| Yokoyama, Yusuke| Ozaki, Toshifumi| |
|---|---|
| 発行日 | 2017-02 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 71巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/54825 |
| JaLCDOI | 10.18926/AMO/30972 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Endo, Hirosuke| Asaumi, Koji| Mitani, Shigeru| Noda, Tomoyuki| Minagawa, Hiroshi| Tetsunaga, Tomonori| Ozaki, Toshifumi| |
| 抄録 | <p>A minimally invasive plate osteosynthesis technique using a locking compression plate (LCP) has been used widely in trauma cases. Its advantages are that the MIPO technique does not interfere with the fracture site and thus provides improved biological healing, and that the LCP has excellent angular stability. Its use in bone lengthening, however, has not been established. In such cases, it is desirable to shorten the external skeletal fixation period as much as possible. Here, the MIPO technique using an LCP was applied to femoral distraction osteogenesis in an attempt to shorten the external skeletal fixation period. For femoral lengthening, the MIPO technique was performed in 2 stages. Orthofix external fixators (Orthofix, England) were used to insert screws from the anterolateral side rather than from the lateral side of the femur for bone lengthening. When sufficient callus formation was detected postoperatively at the site of bone lengthening, and the absence of infection was ensured, limb draping was performed, including a whole external fixator, and then the MIPO technique was applied with an LCP. In 3 cases (5 limbs), the average duration of external skeletal fixation was 134days, the average external-fixation index was 24days/cm, and the average consolidation index was 22days/cm. The MIPO technique using an LCP made it possible to shorten the external skeletal fixation-wearing period in femoral lengthening.</p> |
| キーワード | femoral lengthening minimally invasive plate osteosynthesis locking compression plate external skeletal fixation external-fixation index |
| Amo Type | Original Article |
| 発行日 | 2008-10 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 62巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 333 |
| 終了ページ | 339 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 18985094 |
| Web of Science KeyUT | 000260391300008 |
| JaLCDOI | 10.18926/AMO/32853 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Endo, Hirosuke| Noda, Tomoyuki| Mitani, Shigeru| Nakahara, Ryuichi| Tetsunaga, Tomonori| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| 抄録 | <p>Femoroacetabular impingement (FAI) is a condition characterized by the impingement of the femur and acetabulum. In Japan, this disorder has become recognized gradually. Here we report a rare case of surgically treated FAI, associated with an osseous protrusion on the acetabulum of a 30-year-old female. Plain computed tomography (CT) and reconstructive 3D-CT images clearly demonstrated an anterolateral bony protrusion. Hip arthroscopy showed no degeneration of the cartilage on either the femoral or acetabular side, but degeneration at the edge of labrum was observed in the region of the bony protrusion. The complete removal of the bony protrusion under hip arthroscopy was thus considered impracticable, and a small skin incision was therefore made anteriorly to approach the acetabulum. The Short-Form 36-Item Health Survey (SF-36) revealed improvement in all scores.</p> |
| キーワード | femoroacetabular impingement bony protrusion Pincer type hip arthroscopy SF36 |
| Amo Type | Case Report |
| 発行日 | 2010-04 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 64巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 149 |
| 終了ページ | 154 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20424671 |
| Web of Science KeyUT | 000276996900010 |
| タイトル（別表記） | Japanese guidelines for the treatment of hip fractures in the elderly |
|---|---|
| フルテキストURL | 122_253.pdf |
| 著者 | 野田 知之| 尾﨑 敏文| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2010-12-01 |
| 巻 | 122巻 |
| 号 | 3号 |
| 開始ページ | 253 |
| 終了ページ | 257 |
| ISSN | 0030-1558 |
| 言語 | Japanese |
| 著作権者 | Copyright (c) 2010 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.122.253 |
| NAID | 130004903185 |