| JaLCDOI | 10.18926/AMO/30739 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Aiga, Ayako| Asaumi, Koji| Lee, You Jin| Kadota, Hiroaki| Mitani, Shigeru| Ozaki, Toshifumi| Takigawa, Masaharu| |
| 抄録 | The localization and expression of neurotrophins and their receptors during distraction osteogenesis was investigated in 72 male rat femurs (11 weeks old) to further clarify the concurrence of cellular and molecular events of new bone formation. After osteotomy, a 7-day lag phase was followed by distraction at the rate of 0.25 mm/12 h for 21 days (distraction phase), and a 7-day consolidation phase. The localization of neurotrophins (NGF, BDNF and NT-3) and their receptors tropomyosinrelated kinases (TRKA, TRKB and TRKC) by immunostaining showed positive staining in bone forming cells in each stage, although the presence and staining intensity varied by cell type and phase. The expressions of NGF, BDNF and NT-3 by real-time polymerase chain reaction (real-time PCR) showed that the peak of the mRNA expression of NGF occurred 10 days after distraction. NT-3 increased during bone extension, but decreased when distraction stopped. In contrast, BDNF continued to increase gradually throughout the distraction and consolidation phases. These findings suggest that neurotrophins and their receptors may play different roles in endochondral and intramembranous ossification in distraction osteogenesis. The tension stress caused by distraction may stimulate the expression of neurotrophins and their receptors, and promote osteogenesis. |
| キーワード | neurotrophin Trk distraction osteogenesis mechanical stress |
| Amo Type | Article |
| 発行日 | 2006-10 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 60巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 267 |
| 終了ページ | 277 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17072373 |
| Web of Science KeyUT | 000241509000003 |
| JaLCDOI | 10.18926/AMO/30721 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Inoue, Atsushi| Asaumi, Koji| Endo, Hirosuke| Fujiwara, Kazuo| Mitani, Shigeru| Ozaki, Toshifumi| |
| 抄録 | The present retrospective study assessed radiographs to determine socket wear in total hip arthroplasty (THA) with 22-mm zirconia or COP (Cobalt-Chrome alloy rich in Cobalt and Phosphorous) heads, and in cemented stems at more than 10 years after operation. Sockets of ultra high molecular weight polyethylene were used in each of two THA groups (13 hips each) in a clinical trial in our hospital between 1989 and 1990. Three observers carried out masked assessments of the radiographs. Upon fi nal examination, there was no remarkable loosening in the zirconia or COP group, and no case had required revision surgery as of 2005. There was a statistically signifi cant diff erence between the 2 groups in average annual linear wear, at 0.093 mm/year and 0.046 mm/year in the zirconia and COP groups, respectively. Volume wear and average annual volume wear were also signifi cantly greater in the zirconia group despite its superior mechanical strength and toughness in vitro. Our present fi ndings do not confi rm early expectations of lower wear in long-term results of 22-mm zirconia femoral heads used in THA. |
| キーワード | total hip arthroplasty zirconia head COP head polyethylene wear |
| Amo Type | Original Article |
| 発行日 | 2006-12 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 60巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 311 |
| 終了ページ | 318 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17189974 |
| Web of Science KeyUT | 000243019000002 |
| 著者 | 田中 雅人| 杉本 佳久| 三澤 治夫| 高畑 智宏| 尾﨑 敏文| |
|---|---|
| 発行日 | 2010-04-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 三村 秀文| 藤原 寛康| 平木 隆夫| 郷原 英夫| 芝本 健太郎| 木股 敬裕| 尾﨑 敏文| 佐々木 了| 金澤 右| |
|---|---|
| 発行日 | 2010-04-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 尾﨑 敏文| |
|---|---|
| 発行日 | 2006-01-04 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 117巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 国定 俊之| 尾﨑 敏文| |
|---|---|
| 発行日 | 2008-05-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 120巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| フルテキストURL | K000901.pdf |
|---|---|
| 著者 | 尾崎 敏文| |
| 発行日 | 1991-03-28 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第901号 |
| 学位授与年月日 | 1991-03-28 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | Japanese |