フルテキストURL s12885-017-3295-4.pdf
著者 Yokota, T.| Ogawa, T.| Takahashi, S.| Okami, K.| Fujii, T.| Tanaka, K.| Iwae, S.| Ota, I.| Ueda, T.| Monden, N.| Matsuura, K.| Kojima, H.| Ueda, S.| Sasaki, K.| Fujimoto, Y.| Hasegawa, Y.| Beppu, T.| Nishimori, Hisakazu| Hirano, S.| Naka, Y.| Matsushima, Y.| Fujii, M.| Tahara, M.|
抄録 BACKGROUND: Recent preclinical and phase I studies have reported that rebamipide decreased the severity of chemoradiotherapy-induced oral mucositis in patients with oral cancer. This placebo-controlled randomized phase II study assessed the clinical benefit of rebamipide in reducing the incidence of severe chemoradiotherapy-induced oral mucositis in patients with head and neck cancer (HNC). METHODS: Patients aged 20-75 years with HNC who were scheduled to receive chemoradiotherapy were enrolled. Patients were randomized to receive rebamipide 2% liquid, rebamipide 4% liquid, or placebo. The primary endpoint was the incidence of grade ≥ 3 oral mucositis determined by clinical examination and assessed by central review according to the Common Terminology Criteria of Adverse Events version 3.0. Secondary endpoints were the time to onset of grade ≥ 3 oral mucositis and the incidence of functional impairment (grade ≥ 3) based on the evaluation by the Oral Mucositis Evaluation Committee. RESULTS: From April 2014 to August 2015, 97 patients with HNC were enrolled, of whom 94 received treatment. The incidence of grade ≥ 3 oral mucositis was 29% and 25% in the rebamipide 2% and 4% groups, respectively, compared with 39% in the placebo group. The proportion of patients who did not develop grade ≥ 3 oral mucositis by day 50 of treatment was 57.9% in the placebo group, whereas the proportion was 68.0% in the rebamipide 2% group and 71.3% in the rebamipide 4% group. The incidences of adverse events potentially related to the study drug were 16%, 26%, and 13% in the placebo, rebamipide 2%, and rebamipide 4% groups, respectively. There was no significant difference in treatment compliance among the groups. CONCLUSIONS: The present phase II study suggests that mouth washing with rebamipide may be effective and safe for patients with HNC receiving chemoradiotherapy, and 4% liquid is the optimal dose of rebamipide. TRIAL REGISTRATION: ClinicalTrials.gov under the identifier NCT02085460 (the date of trial registration: March 11, 2014).
キーワード Chemoradiotherapy Head and neck cancer Oral mucositis Placebo-controlled Randomized Rebamipide liquid
発行日 2017-05-05
出版物タイトル BMC cancer
17巻
1号
出版者 BioMed Central
開始ページ 314
終了ページ 322
ISSN 1471-2407
NCID AA12034763
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 28476132
DOI 10.1186/s12885-017-3295-4
Web of Sience KeyUT 000401614700001
関連URL https://doi.org/10.1186/s12885-017-3295-4
フルテキストURL K0005304 other1.pdf
著者 Igawa, Takuro| Sato, Yasuharu| Takata, Katsuyoshi| Iwaki, Noriko| Tanaka, Takehiro| Asano, Naoko| Maeda, Yoshinobu| Orita, Yorihisa| Nakamura, Naoya| Nakamura, Shigeo| Yoshino, Tadashi|
抄録  D cyclins positively regulate the cell cycle and mediate the pathogenesis of some lymphomas. Cyclin D1 overexpression is the hallmark of mantle cell lymphoma, whereas cyclins D2 and D3 are reportedly not as specific to certain lymphomas as cyclin D1. In this study, cyclin D2 was found to be overexpressed in 98% of de novo CD5-positive diffuse large B-cell lymphomas (DLBCLs) (50/51) and in 28% of CD5-negative DLBCLs (14/51). A statistically significant difference was observed between these two groups (p<0.0001). In contrast, no statistical difference was found in the cyclin D3 expression between CD5-positive (18/51) and CD5-negative (24/51) DLBCLs (p=0.23). Based on these findings, cyclin D2 is therefore considered to be closely associated with de novo CD5-positive DLBCLs. This insight may be useful for overcoming the inferior survival of this aggressive lymphoma.
キーワード Cyclin D2 CD5 Diffuse large B-cell lymphoma
備考 学位審査副論文
発行日 2013-05-15
出版物タイトル Diagnostic Pathology
8巻
出版者 BioMed Central
開始ページ 81
ISSN 1746-1596
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 23675804
DOI 10.1186/1746-1596-8-81
Web of Sience KeyUT 000319266300002
関連URL https://doi.org/10.1186/1746-1596-8-81 http://ousar.lib.okayama-u.ac.jp/54287
著者 Takahashi, Shunichi| Tamashiro, Ayumu| Sakihama, Yasuko| Yamamoto, Yasusi| Kawamitsu, Yoshinobu| Yamasaki, Hideo|
発行日 2002-04-02
出版物タイトル BMC Plant Biology
2巻
資料タイプ 学術雑誌論文
著者 Moritani, Norifumi H| Kubota, Satoshi| Sugahara, Toshio| Takigawa, Masaharu|
発行日 2005-04-15
出版物タイトル Cell Communication and Signaling
3巻
1号
資料タイプ 学術雑誌論文
著者 Asano, Masahiro| Kubota, Satoshi| Nakanishi, Tohru| Nishida, Takashi| Yamaai, Tomoichiro| Yosimichi, Gen| Ohyama, Kazumi| Sugimoto, Tomosada| Murayama, Yoji| Takigawa, Masaharu|
発行日 2005-10-05
出版物タイトル Cell Communication and Signaling
3巻
1号
資料タイプ 学術雑誌論文
著者 Nakai, Yukie| Milgrom, Peter| Yoshida, Toshiko| Ishihara, Chikako| Shimono, Tsutomu|
発行日 2005-8-23
出版物タイトル BMC Medical Research Methodology
5巻
資料タイプ 学術雑誌論文
著者 Kawai, Mariko| Bessho, Kazuhisa| Maruyama, Hiroki| Miyazaki, Jun-ichi| Yamamoto, Toshio|
発行日 2006-08-03
出版物タイトル BMC Musculoskeletal Disorders
7巻
資料タイプ 学術雑誌論文
著者 Uchida, Naohiko| Ujike, Hiroshi| Nakata, Kenji| Takaki, Manabu| Nomura, Akira| Katsu, Takeshi| Tanaka, Yuji| Imamura, Takaki| Sakai, Ayumu| Kuroda, Shigetoshi|
発行日 2003-10-21
出版物タイトル BMC Psychiatry
3巻
資料タイプ 学術雑誌論文
著者 Matsumoto, Eiji| Nakatsuka, Harushige| Nouso, Kazuhiro| Nakamura, Shin-ichiro| Suzuki, Mayumi| Kobayashi, Yoshiyuki| Uemura, Masayuki| Sato, Syuichiro| Sato, Ei-ichiro| Yokoyama, Junko| Tsuboi, Sou| Tanaka, Hironori| Takuma, Yoshitake| Fujikawa, Tatsuya| Shiratori, Yasushi|
発行日 2004-01-14
出版物タイトル Comparative Hepatology
3巻
資料タイプ 学術雑誌論文
著者 Altundag, Kadri| Altundag, Ozden| Gunduz, Mehmet|
発行日 2004-06-15
出版物タイトル Breast Cancer Research
6巻
4号
資料タイプ 学術雑誌論文
著者 Tsujita-Kyutoku, Miki| Yuri, Takashi| Danbara, Naoyuki| Senzaki, Hideto| Kiyozuka, Yasuhiko| Uehara, Norihisa| Takada, Hideho| Hada, Takahiko| Miyazawa, Teruo| Ogawa, Yutaka| Tsubura, Airo|
発行日 2004-04-26
出版物タイトル Breast Cancer Research
6巻
4号
資料タイプ 学術雑誌論文
著者 Hanafusa, Tadashi| Shinji, Toshiyuki| Shiraha, Hidenori| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Yumoto, Eichiro| Ono, Toshiro| Koide, Norio|
発行日 2005-01-20
出版物タイトル BMC Cancer
5巻
資料タイプ 学術雑誌論文