フルテキストURL IFAC_49_8_7.pdf
著者 Imai, Jun| Noso, Katsuyuki| Takahashi, Akiko| Funabiki, Shigeyuki|
抄録 For linear distributed parameter systems with a finite number of boundary inputs, we propose a framework to implement the method of weighted residuals using candidate trial functions without boundary homogenization. Proposed scheme utilizes inner product matrix, or Grammian, of the trial functions to separate appropriate homogenized basis functions and the other trial functions matching inhomogeneous boundary conditions. The finite-dimensional approximate model by using the proposed scheme is represented in descriptor form and it is proved to be straightforwardly transformed into state space form. Feasibility of the method is illustrated by a brief controller design example using the approximate model of a heat conduction rod with Dirichlet boundary input.
キーワード Distributed parameter systems Method of weighted residuals Boundary conditions Reduced-order models
備考 This is an Accepted Manuscript of an article published by Elsevier
発行日 2016-08-09
出版物タイトル IFAC-Papers OnLine
49巻
8号
出版者 Elsevier
開始ページ 7
終了ページ 12
ISSN 2405-8963
資料タイプ 学術雑誌論文
言語 Japanese
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
DOI 10.1016/j.ifacol.2016.07.410
Web of Sience KeyUT 000381505200003
関連URL https://doi.org/10.1016/j.ifacol.2016.07.410
著者 Hashimoto, Mitsuyasu|
抄録 Using the description of the Frobenius limit of modules over the ring of invariants under an action of a finite group on a polynomial ring over a field of characteristic p>0 developed by Symonds and the author, we give a characterization of the ring of invariants with a positive dual F-signature. Combining this result and Kemper's result on depths of the ring of invariants under an action of a permutation group, we give an example of an F-rational, but non-F-regular ring of invariants under the action of a finite group.
キーワード F-rational F-regular Dual F-signature Frobenius limit
備考 This is an Accepted Manuscript of an article published by Elsevier This fulltext available in Aug 2019
発行日 2017-08-15
出版物タイトル Journal of Algebra
484巻
出版者 Elsevier
開始ページ 207
終了ページ 223
ISSN 0021-8693
NCID AA00692420
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
DOI 10.1016/j.jalgebra.2017.04.017
Web of Sience KeyUT 000403626100010
関連URL https://doi.org/10.1016/j.jalgebra.2017.04.017
著者 Hashimoto, Mitsuyasu| Symondsb, Peter|
抄録 We define the Frobenius limit of a module over a ring of prime characteristic to be the limit of the normalized Frobenius direct images in a certain Grothendieck group. When a finite group acts on a polynomial ring, we calculate this limit for all the modules over the twisted group algebra that are free over the polynomial ring; we also calculate the Frobenius limit for the restriction of these to the ring of invariants. As an application, we generalize the description of the generalized F-signature of a ring of invariants by the second author and Nakajima to the modular case.
キーワード Frobenius direct image Hilbert–Kunz multiplicity F-signature Frobenius limit
備考 This is an Accepted Manuscript of an article published by Elsevier Fulltext available in Jan 2019
発行日 2017-01-10
出版物タイトル Advances in Mathematics
305巻
出版者 Elsevier
開始ページ 144
終了ページ 164
ISSN 0001-8708
NCID AA00513055
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
DOI 10.1016/j.aim.2016.09.020
Web of Sience KeyUT 000406169200003
関連URL https://doi.org/10.1016/j.aim.2016.09.020
フルテキストURL BBRC_480_4_564_highlights.pdf BBRC_480_4_564_fig.pdf BBRC_480_4_564_suppl_fig.pdf
著者 Ujihara, Yoshihiro| Mohria, Satoshi| Katanosaka, Yuki|
抄録 The Na+/Ca2+ exchanger 1 (NCX1) is an essential Ca2+ efflux system in cardiomyocytes. Although NCX1 is distributed throughout the sarcolemma, a subpopulation of NCX1 is localized to transverse (T)-tubules. There is growing evidence that T-tubule disorganization is a causal event that shifts the transition from hypertrophy to heart failure (HF). However, the detailed molecular mechanisms have not been clarified. Previously, we showed that induced NCX1 expression in pressure-overloaded hearts attenuates defective excitation-contraction coupling and HF progression. Here, we examined the effects of induced NCX1 overexpression on the spatial distribution of L-type Ca2+ channels (LTCCs) and junctophilin-2 (JP2), a structural protein that connects the T-tubule and sarcoplasmic reticulum membrane, in pressure-overloaded hearts. Quantitative analysis showed that the regularity of NCX1 localization was significantly decreased at 8 weeks after transverse aortic constriction (TAC)-surgery; however, T-tubule organization and the regularities of LTCC and JP2 immunofluorescent signals were maintained at this time point. These observations demonstrated that release of NCX1 from the T-tubule area occurred before the onset of T-tubule disorganization and LTCC and JP2 mislocalization. Moreover, induced NCX1 overexpression at 8 weeks post-TAC not only recovered NCX1 regularity but also prevented the decrease in LTCC and JP2 regularities at 16 weeks post-TAC. These results suggested that NCX1 may play an important role in the proper spatial distribution of LTCC and JP2 in T-tubules in the context of pressure-overloading.
キーワード Heart failure Junctophilin-2 L-type Ca(2+) channel Na(+)/Ca(2+) exchanger 1 Pressure-overloading Transverse-tubule
備考 2017年11月公開予定
発行日 2016/11
出版物タイトル Biochemical and Biophysical Research Communications
480巻
4号
出版者 Elsevier
開始ページ 564
終了ページ 569
ISSN 0006-291X
NCID AA00564395
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 27789286
DOI 10.1016/j.bbrc.2016.10.090
Web of Sience KeyUT 000389015400011
関連URL https://doi.org/10.1016/j.bbrc.2016.10.090
著者 Kawaguchi, Yuka| Nariki, Hiroaki| Kawamoto, Naoko| Kanehiro, Yuichi| Miyazaki, Satoshi| Suzuki, Mari| Magari, Masaki| Tokumitsu, Hiroshi| Kanayama, Naoki|
抄録  Activation-induced cytidine deaminase (AID) is essential for diversification of the Ig variable region (IgV). AID is excluded from the nucleus, where it normally functions. However, the molecular mechanisms responsible for regulating AID localization remain to be elucidated. The SR-protein splicing factor SRSF1 is a nucleocytoplasmic shuttling protein, a splicing isoform of which called SRSF1-3, has previously been shown to contribute to IgV diversification in chicken DT40 cells. In this study, we examined whether SRSF1-3 functions in IgV diversification by promoting nuclear localization of AID. AID expressed alone was localized predominantly in the cytoplasm. In contrast, co-expression of AID with SRSF1-3 led to the nuclear accumulation of both AID and SRSF1-3 and the formation of a protein complex that contained them both, although SRSF1-3 was dispensable for nuclear import of AID. Expression of either SRSF1-3 or a C-terminally-truncated AID mutant increased IgV diversification in DT40 cells. However, overexpression of exogenous SRSF1-3 was unable to further enhance IgV diversification in DT40 cells expressing the truncated AID mutant, although SRSF1-3 was able to form a protein complex with the AID mutant. These results suggest that SRSF1-3 promotes nuclear localization of AID probably by forming a nuclear protein complex, which might stabilize nuclear AID and induce IgV diversification in an AID C-terminus-dependent manner.
キーワード AID DT40 Gene conversion Ig SRSF1 Somatic hypermutation
備考 2018年4月公開予定
発行日 2017-04
出版物タイトル Biochemical and Biophysical Research Communications
485巻
2号
出版者 Elsevier
開始ページ 261
終了ページ 266
ISSN 0006-291X
NCID AA00564395
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 28235482
DOI 10.1016/j.bbrc.2017.02.097
Web of Sience KeyUT 000396798300007
関連URL https://doi.org/10.1016/j.bbrc.2017.02.097
フルテキストURL K0005273 other2.pdf
著者 Sakamoto, Shinji| Takaki, Manabu| Okahisa, Yuko| Mizuki, Yutaka| Kodama, Masafumi| Ujike, Hiroshi| Uchitomi, Yosuke|
備考 学位審査副論文
発行日 2014-05
出版物タイトル Psychiatry Research
216巻
2号
出版者 Elsevier
開始ページ 288
終了ページ 289
ISSN 0165-1781
NCID AA0036432X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 24576429
DOI 10.1016/j.psychres.2014.02.006
Web of Sience KeyUT 000335099900020
関連URL https://doi.org/10.1016/j.psychres.2014.02.006
フルテキストURL K0005427_other1.pdf
著者 Okano, Mitsuhiro| Fujiwara, Tazuko| Kariya, Shin| Higaki, Takaya| Makihara, Sei-ichiro| Haruna, Takenori| Noyama, Yasuyuki| Koyama, Takahisa| Omichi, Ryotaro| Orita, Yorihisa| Miki, Kentaro| Kanai, Kengo| Nishizaki, Kazunori|
抄録 BACKGROUND: Toll-like receptor 3 (TLR3) is expressed in upper airways, however, little is known regarding whether Toll-like receptor 3 (TLR3) signals exert a regulatory effect on the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP), especially on eosinophilic inflammation. We sought to investigate the effect of Poly(IC), the ligand for TLR3, on cytokine production by dispersed nasal polyp cells (DNPCs). METHODS: DNPCs were pretreated with or without Poly(IC), and were then cultured in the presence or absence of staphylococcal enterotoxin B (SEB), following which the levels of IL-5, IL-10, IL-13, IL-17A and interferon (IFN)-γ in the supernatant were measured. To determine the involvement of IL-10 and cyclooxygenase in Poly(IC)-mediated signaling, DNPCs were treated with anti-IL-10 monoclonal antibody and diclofenac, the cyclooxygenase inhibitor, respectively. Poly(IC)-induced prostaglandin E2 (PGE2) production was also determined. RESULTS: Exposure to Poly(IC) induced a significant production of IL-10, but not of IL-5, IL-13, IL-17A or IFN-γ by DNPCs. Pretreatment with Poly(IC) dose-dependently inhibited SEB-induced IL-5, IL-13 and IL-17A, but not IFN-γ production. Neutralization of IL-10 significantly abrogated the inhibitory effect of Poly(IC). Treatment with diclofenac also abrogated the inhibitory effect of Poly(IC) on SEB-induced IL-5 and IL-13 production. However, unlike exposure of diclofenac-treated DNPCs to lipopolysaccharide, the ligand for TLR4, exposure of these cells to Poly(IC) did not enhance IL-5 or IL-13 production. Poly(IC) did not significantly increase PGE2 production by DNPCs. CONCLUSIONS: These results suggest that TLR3 signaling regulates eosinophilia-associated cytokine production in CRSwNP, at least in part, via IL-10 production.
キーワード Chronic rhinosinusitis with nasal polyps IL-10 IL-5 Poly(IC) Toll-like receptor
備考 学位審査副論文
発行日 2016-01
出版物タイトル Allergology international : official journal of the Japanese Society of Allergology
65巻
1号
出版者 Elsevier
開始ページ 96
終了ページ 102
ISSN 1323-8930
NCID AA11091750
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 26666485
Web of Sience KeyUT 000367238600015
関連URL https://doi.org/10.1016/j.alit.2015.08.005 http://ousar.lib.okayama-u.ac.jp/54846
著者 Yoshioka-Nishimura, Miho| Yamamoto, Yasusi|
発行日 2014
出版物タイトル Journal of Photochemistry and Photobiology B: Biology
137巻
資料タイプ 学術雑誌論文
著者 Matsuura, Koji| Takenami, Mami| Kuroda, Yuka| Hyakutake, Toru| Yanase, Shinichiro| Naruse, Keiji|
発行日 2012-01
出版物タイトル Reproductive BioMedicine Online
24巻
1号
資料タイプ 学術雑誌論文
著者 Matsuura, Koji| Hayashi, Nobuyoshi| Takiue, Chisato| Hirata, Rei| Habara, Toshihiro| Naruse, Keiji|
発行日 2010-08
出版物タイトル Fertility and Sterility
94巻
3号
資料タイプ 学術雑誌論文
著者 Sano, Hikaru| Matsuura, Koji| Naruse, Keiji| Funahashi, Hiroaki|
発行日 2010-09-15
出版物タイトル Theriogenology
74巻
5号
資料タイプ 学術雑誌論文
著者 Matsuura, Koji| Hayashi, Nobuyoshi| Kuroda, Yuka| Takiue, Chisato| Hirata, Rei| Takenami, Mami| Aoi, Yoko| Yoshioka, Nanako| Habara, Toshihiro| Mukaida, Tetsunori| Naruse, Keiji|
発行日 2010-03
出版物タイトル Reproductive BioMedicine Online
20巻
3号
資料タイプ 学術雑誌論文
著者 Nohara, Minoru| Kakiya, Satomi| Kudo, Kazutaka| Oshiro, Yoshihiro| Araki, Shingo| Kobayashi, Tatsuo C.| Oku, Kenta| Nishibori, Eiji| Sawa, Hiroshi|
発行日 2012-04
出版物タイトル Solid State Communications
152巻
8号
資料タイプ 学術雑誌論文
著者 Nishioka, Yasutaka| Suzumori, Koichi| Kanda, Takefumi| Wakimoto, Shuichi|
発行日 2010-12
出版物タイトル Sensors and Actuators A: Physical
164巻
1-2号
資料タイプ 学術雑誌論文
著者 Okazaki, Hiroyuki| Yoshida, Rikiya| Iwai, Keisuke| Noami, Kengo| Muro, Takayuki| Nakamura, Tetsuya| Wakita, Takanori| Muraoka, Yuji| Hirai, Masaaki| Tomioka, Fumiaki| Takano, Yoshihiko| Takenaka, Asami| Toyoda, Masahiro| Oguch, Tamio| Yokoya, Takayoshi|
発行日 2010-12
出版物タイトル Physica C-Superconductivity and its Applications
470巻
S1号
資料タイプ 学術雑誌論文
著者 Yoshida, Rikiya| Wakita, Takanori| Okazaki, Hiroyuki| Mizuguchi, Yoshikazu| Tsuda, Shunsuke| Takano, Yoshihiko| Takeya, Hiroyuki| Hirata, Kazuto| Kato, Yukako| Muro, Takayuki| Okawa, Mario| Ishizaka, Kyoko| Shin, Shik| Harima, Hisatomo| Hirai, Masaaki| Muraoka, Yuji| Yokoya, Takayoshi|
発行日 2010-12
出版物タイトル Physica C-Superconductivity and its Applications
470巻
S1号
資料タイプ 学術雑誌論文
著者 Wakita, Takanori| Okazaki, Hiroyuki| Takano, Yoshihiko| Hirai, Masaaki| Muraoka, Yuji| Yokoya, Takayoshi|
発行日 2010-12
出版物タイトル Physica C-Superconductivity and its Applications
470巻
S1号
資料タイプ 学術雑誌論文
著者 Muraoka, Y| Saeki, K| Yao, Y| Wakita, T| Hirai, M| Yokoya, T| Eguchi, R| Shin, S|
発行日 2010-08
出版物タイトル Journal of Electron Spectroscopy and Related Phenomena
181巻
2-3号
資料タイプ 学術雑誌論文
著者 Khan, Shahbaz Manzoor| Debnath, Chanchal| Pramanik, Amiya Kumar| Xiao, Lihua| Nozaki, Tomoyoshi| Ganguly, Sandipan|
発行日 2010-07-15
出版物タイトル Veterinary Parasitology
171巻
1-2号
資料タイプ 学術雑誌論文
著者 Khan, Shahbaz Manzoor| Debnath, Chanchal| Pramanik, Amiya Kumar| Xiao, Lihua| Nozaki, Tomoyoshi| Ganguly, Sandipan|
発行日 2011-06-10
出版物タイトル Veterinary Parasitology
178巻
3-4号
資料タイプ 学術雑誌論文