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ID 48840
フルテキストURL
著者
Kataoka, Takahiro Graduate School of Health Sciences, Okayama University
Yamato, Keiko Graduate School of Health Sciences, Okayama University
Nishiyama, Yuichi Graduate School of Health Sciences, Okayama University
Morii, Yuji Graduate School of Health Sciences, Okayama University
Etani, Reo Graduate School of Health Sciences, Okayama University
Takata, Yuji Graduate School of Health Sciences, Okayama University
Hanamoto, Katsumi Graduate School of Health Sciences, Okayama University
Kawabe, Atsuishi Graduate School of Health Sciences, Okayama University
Sakoda, Akihiro Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Ishimori, Yuu Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Taguchi, Takehito Graduate School of Health Sciences, Okayama University
Yamaoka, Kiyonori Graduate School of Health Sciences, Okayama University
抄録
Since the 2011 nuclear accident in Fukushima, the effects of low-dose irradiation, especially internal exposure, are at the forefront of everyone’s attention. However, low-dose radiation induced various stimulating effects such as activation of antioxidative and immune functions. In this study, we attempted to evaluate the quantitative effects of the activation of antioxidative activities in kidney induced by radon inhalation on carbon tetrachloride (CCl4)-induced renal damage. Mice were subjected to intraperitoneal (i.p.) injection of CCl4 after inhaling approximately 1000 or 2000 Bq/m3 radon for 24 h, or immediately after i.p. injection of α-tocopherol (100, 300, or 500 mg/kg bodyweight). In case of renal function, radon inhalation at a concentration of 2000 Bq/m3 has the inhibitory effects similar to α-tocopherol treatment at a dose of 300–500 mg/kg bodyweight. The activities of superoxide dismutase and catalase in kidneys were significantly higher in mice exposed to radon as compared to mice treated with CCl4 alone. These findings suggest that radon inhalation has an antioxidative effect against CCl4-induced renal damage similar to the antioxidative effects of α-tocopherol due to induction of antioxidative functions.
キーワード
radon
carbon tetrachloride
oxidative damage
α-tocopherol
kidney
発行日
2012-10
出版物タイトル
Renal Failure
34巻
9号
出版者
Informa Healthcare
開始ページ
1181
終了ページ
1187
ISSN
1525-6049
NCID
AA12520251
資料タイプ
学術雑誌論文
オフィシャル URL
http://informahealthcare.com/doi/abs/10.3109/0886022X.2012.717496
言語
English
OAI-PMH Set
岡山大学
論文のバージョン
author
査読
有り
DOI
PubMed ID