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ID 51465
フルテキストURL
著者
Sato, Y. Okayama Univ, Grad Sch Hlth Sci
Ogino, K. Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth
Sakano, N. Kagawa Univ, Fac Med, Dept Hyg
Wang, D. H. Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth
Yoshida, J. Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth
Akazawa, Y. Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth
Kanbara, S. Kochi Univ, Fac Nursing
Inoue, K. Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth
Kubo, M. Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth
Takahashi, H. Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth
抄録
The usefulness of urinary hydrogen peroxide (H2O2) as an oxidative stress biomarker was evaluated in 766 healthy Japanese. The mean level of urinary concentrations of H2O2 was 5.66 +/- 8.27 mu mol/g creatinine, and was significantly higher in females than in males. Significant correlations of H2O2 were observed with age, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), insulin, 8-hydroxy-2'-deoxyguanosine (8-OHdG), and exercise habit in females. In both sexes, H2O2 showed a significant correlation with 8-OHdG. By a multiple logistic regression analysis, urinary H2O2 was positively associated with urinary 8-OHdG and TC and was inversely associated with insulin. By stratification of sex and age, the association of urinary H2O2 with TC was positive in both sexes under 50 years old and was inverse in males over 50 years old, and that with insulin was inverse in males over 50 years old and in females under 50 years old. Moreover, by stratification of sex and age, a positive association of H2O2 with exercise and an inverse association of H2O2 with alcohol consumption became clear in males under 50 years old, although there were no significant odds for H2O2 after adjustment for covariates. In conclusion, the present results suggest that urinary H2O2 is a useful biomarker for oxidative stress, showing an association with 8-OHdG, TC, and insulin independently.
キーワード
H2O2
8-OHdG
lifestyle
total cholesterol
exercise
発行日
2013-03
出版物タイトル
Free Radical Research
47巻
3号
出版者
Informa Healthcare
開始ページ
181
終了ページ
191
ISSN
1071-5762
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.3109/10715762.2012.759218
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/51463
言語
English
OAI-PMH Set
岡山大学
論文のバージョン
author
査読
有り
DOI
Web of Sience KeyUT