フルテキストURL K0005299_other2.pdf
著者 Itoh, Hideshi| Ichiba, Shing| Ujike, Yoshihito| Douguchi, Takuma| Kasahara, Shingo| Arai, Sadahiko| Sano, Shunji|
抄録 OBJECT:  We compared the clinical effectiveness and biocompatibility of poly-2-methoxyethyl acrylate (PMEA)-coated and heparin-coated cardiopulmonary bypass (CPB) circuits in a prospective pediatric trial.  METHODS:  Infants randomly received heparin-coated (n=7) or PMEA-coated (n=7) circuits in elective pediatric cardiac surgery with CPB for ventricular septum defects. Clinical and hematologic variables, respiratory indices and hemodynamic changes were analyzed perioperatively.  RESULTS:  Demographic and clinical variables were similar in both groups. Leukocyte counts were significantly lower 5 minutes after CPB in the PMEA group than the heparin group. Hemodynamic data showed that PMEA caused hypotension within 5 minutes of CPB. The respiratory index was significantly higher immediately after CPB and 1 hour after transfer to the intensive care unit (ICU) in the PMEA group, as were levels of C-reactive protein 24 hours after transfer to the ICU.  CONCLUSION:  Our study shows that PMEA-coated circuits, unlike heparin-coated circuits, cause transient leukopenia during pediatric CPB and, perhaps, systemic inflammatory respiratory syndrome after pediatric CPB.
キーワード PMEA coating cardiopulmonary bypass heparin coating pediatric transient leukopenia
備考 学位審査副論文
発行日 2016-04
出版物タイトル Perfusion
31巻
3号
出版者 Sage
開始ページ 247
終了ページ 254
ISSN 0267-6591
NCID AA10674287
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 26228276
DOI 10.1177/0267659115598217
Web of Sience KeyUT 000373410300010
関連URL https://doi.org/10.1177/0267659115598217 http://ousar.lib.okayama-u.ac.jp/54282